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 **Type:** Conference presentation\\ **Type:** Conference presentation\\
 **Presenter:**  Trevor Marshall, PhD\\ **Presenter:**  Trevor Marshall, PhD\\
-**Conference:**  [[http://www.bitlifesciences.com/wcg2008/event_report.htm|2008 World Congress of Gene]]\\+**Conference:**  [[https://www.bitlifesciences.com/wcg2008/event_report.htm|2008 World Congress of Gene]]\\
 **Location:**  Foshan, China\\ **Location:**  Foshan, China\\
 **Date:**  December 5-7, 2008\\ **Date:**  December 5-7, 2008\\
-**Notes:** [[http://AutoimmunityResearch.org/transcripts/WCG2008_Keynote_Transcript.pdf|transcript]]+**Notes:** [[https://AutoimmunityResearch.org/transcripts/WCG2008_Keynote_Transcript.pdf|transcript]]
  
  
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-===== Appraisal of talk by Future Medicine =====+===== Appraisal of talk by Personalized Medicine =====
  
 In his article, "A New Series of International Genetic Congresses Take Place in China," Hansjörg Rothe appraised by this talk, saying in part: In his article, "A New Series of International Genetic Congresses Take Place in China," Hansjörg Rothe appraised by this talk, saying in part:
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 <blockquote>While he represented high-profile bench research providing visions for future drug development, Trevor G. Marshall, PhD, from Murdoch University (Brisbane, Australia) focused on a topic that is very much present in clinical daily routine, and how today's gene technology may change our views on the very nature of a common problem - chronic inflammatory disorders. In his fascinating talk entitled "Understanding chronic disease requires study of the metagenome, not just the human genome", he explained how the new shotgun and clonal sequencing technologies lead to the surprising discovery of "a plethora of symbiotic and pathogenic prokaryotic and viral genomes... microbes never thought to persist in man". He went on to discuss present data from his group concerning persistent intraphagocytic microbiota, which had developed survival strategies by inhibiting the vitamin-D-receptor-mediated transcription of cathelicidin and defemin antimicrobial peptides, thereby evading the innate immune mechanism of phagocytosis. In an intriguing argument, Marshall - who is not a medical doctor, but a computer modelling expert - proceeded to challenge the 100-year-old postulates of Robert Koch - "one microbial agent for each disease, and that disease must betransmissible". Indeed, we might have to look at the human body as a metagenome, with various persistent microbiota interfering with the human genome's mechanisms such as transcription, mutation and DNA repair — this sheds new light on chronic "autoimmune" conditions induding fibromyalgia and chronic fatigue syndrome, which apparantly have been shown in recent studies to respond to long-term treatment with vitamin D receptor agonists plus subinhibitory bacteriostatic drugs. However, the clinical value of this so-called 'Marshall protocol' will have to tested in further studies.  <blockquote>While he represented high-profile bench research providing visions for future drug development, Trevor G. Marshall, PhD, from Murdoch University (Brisbane, Australia) focused on a topic that is very much present in clinical daily routine, and how today's gene technology may change our views on the very nature of a common problem - chronic inflammatory disorders. In his fascinating talk entitled "Understanding chronic disease requires study of the metagenome, not just the human genome", he explained how the new shotgun and clonal sequencing technologies lead to the surprising discovery of "a plethora of symbiotic and pathogenic prokaryotic and viral genomes... microbes never thought to persist in man". He went on to discuss present data from his group concerning persistent intraphagocytic microbiota, which had developed survival strategies by inhibiting the vitamin-D-receptor-mediated transcription of cathelicidin and defemin antimicrobial peptides, thereby evading the innate immune mechanism of phagocytosis. In an intriguing argument, Marshall - who is not a medical doctor, but a computer modelling expert - proceeded to challenge the 100-year-old postulates of Robert Koch - "one microbial agent for each disease, and that disease must betransmissible". Indeed, we might have to look at the human body as a metagenome, with various persistent microbiota interfering with the human genome's mechanisms such as transcription, mutation and DNA repair — this sheds new light on chronic "autoimmune" conditions induding fibromyalgia and chronic fatigue syndrome, which apparantly have been shown in recent studies to respond to long-term treatment with vitamin D receptor agonists plus subinhibitory bacteriostatic drugs. However, the clinical value of this so-called 'Marshall protocol' will have to tested in further studies. 
  
-//**Hansjörg Rothe**, [[http://www.futuremedicine.com/doi/pdfplus/10.2217/17410541.6.2.143?cookieSet=1|Future Medicine]]//+//**Hansjörg Rothe**, [[https://www.futuremedicine.com/doi/pdfplus/10.2217/17410541.6.2.143?cookieSet=1|Future Medicine]]//
 </blockquote> </blockquote>
  
 {{tag>presentations videos Trevor_Marshall_PhD 2008}} {{tag>presentations videos Trevor_Marshall_PhD 2008}}
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