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home:starting:physician:reluctant [04.15.2019]
sallieq [Specific research]
home:starting:physician:reluctant [04.15.2019] (current)
sallieq [Specific research]
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 {{ :​home:​mp:​olmesartan:​4hr_6hr_matched.jpg?​nolink&​300|4 hourly compared to 6 hourly dosing}} {{ :​home:​mp:​olmesartan:​4hr_6hr_matched.jpg?​nolink&​300|4 hourly compared to 6 hourly dosing}}
  
-The ROADMAP study will answer the question whether an ARB can prevent or delay the onset of microalbuminuria and whether this translates into protection against cardiovascular events and renal disease. (({{pubmed>​long:​16508590}})) ​+The ROADMAP study will answer the question whether an ARB can prevent or delay the onset of microalbuminuria and whether this translates into protection against cardiovascular events and renal disease. (({{pubmed>​long:​16508590}})) ​PMID 16508590
  
 short extract for each research study follows: short extract for each research study follows:
  
  
-Benefits of RAS blockade with olmesartan treatment are sustained after study discontinued. (({{pubmed>​long:​24772521}}))+Benefits of RAS blockade with olmesartan treatment are sustained after study discontinued. (({{pubmed>​long:​24772521}})) ​PMID 24772521
  
  
-Olmesartan significantly reduced myocardial infarct size and improved LV contractility at a dose (3 mg/kg) with systemic vasodilating effects but not at a lower dose (0.3 mg/kg) without hemodynamic effects.(in rat)(({{pubmed>​long:​88888888}}))+Olmesartan significantly reduced myocardial infarct size and improved LV contractility at a dose (3 mg/kg) with systemic vasodilating effects but not at a lower dose (0.3 mg/kg) without hemodynamic effects.(in rat)(({{pubmed>​long:​88888888}})) ​ PMID 88888888
  
-Inhibition of renin-angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation. (({{pubmed>​long:​19304450}})) ​+Inhibition of renin-angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation. (({{pubmed>​long:​19304450}})) ​  PMID 19304450
  
-Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity & apoptosis induction against tumour cells in breast cancer (({{pubmed>​long:​26138656}}))+Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity & apoptosis induction against tumour cells in breast cancer (({{pubmed>​long:​26138656}})) ​ PMID 26138656
 10)  10) 
  
-Alzheimer'​s disease and dementia1 (({{pubmed>​long:​20068258}}))+Alzheimer'​s disease and dementia1 (({{pubmed>​long:​20068258}})) ​ PMID 20068258
  
  
-prevent migraines (({{pubmed>​long:​12503978}}))+prevent migraines (({{pubmed>​long:​12503978}})) ​ PMID 12503978
  
  
-inhibit liver fibrosis and aid liver healing (({{pubmed>​long:​12871826}}))+inhibit liver fibrosis and aid liver healing (({{pubmed>​long:​12871826}})) ​ PMID 12871826
  
  
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-protect the mitochondria from age-associated damage from oxidation (({{pubmed>​long:​12709417}}))+protect the mitochondria from age-associated damage from oxidation (({{pubmed>​long:​12709417}})) ​ PMID 12709417
  
  
-reduce liver fibrosis (({{pubmed>​long:​19303015}}))+reduce liver fibrosis (({{pubmed>​long:​19303015}})) ​ PMID 19303015
  
  
-treatment of anxiety and stress-related disorders (({{pubmed>​long:​15837532}}))+treatment of anxiety and stress-related disorders (({{pubmed>​long:​15837532}})) ​ PMID 15837532
  
  
-inflammation in myocarditis (({{pubmed>​long:​16336207}}))+inflammation in myocarditis (({{pubmed>​long:​16336207}})) ​ PMID 16336207
  
  
-C-reactive protein, one of the acute phase proteins that increase during systemic inflammation (({{pubmed>​long:​16939632}}))+C-reactive protein, one of the acute phase proteins that increase during systemic inflammation (({{pubmed>​long:​16939632}})) ​ PMID 16939632
  
  
-cytokine damage (({{pubmed>​long:​88888888}}))+cytokine damage (({{pubmed>​long:​88888888}})) ​ ​PMID ​
  
-in circadian rhythms between HR and MAP in CKD: Synchronization between the two rhythms was progressively lost as renal function deteriorated,​ and Olmesartan partly restored the synchronization (({{pubmed>​long:​23511341}}))+in circadian rhythms between HR and MAP in CKD: Synchronization between the two rhythms was progressively lost as renal function deteriorated,​ and Olmesartan partly restored the synchronization (({{pubmed>​long:​23511341}})) ​ PMID 23511341
  
-renal protective effects of olmesartan may be better than those of other ARBs (({{pubmed>​long:​24384547}}))+renal protective effects of olmesartan may be better than those of other ARBs (({{pubmed>​long:​24384547}})) ​ PMID 23511341
  
-olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects (({{pubmed>​long:​24842388}})) ​+olmesartan may uniquely increase urinary ACE2 level, which could offer additional renoprotective effects (({{pubmed>​long:​24842388}})) ​  PMID 24842388
  
  
-* treatment with olmesartan inhibited bone loss (({{pubmed>​long:​25363367}}))+* treatment with olmesartan inhibited bone loss (({{pubmed>​long:​25363367}})) ​ PMID 25363367
  
  
-* olmesartan protects endothelial cells against oxidative stress-mediated cellular injury (({{pubmed>​long:​25904217}}))+* olmesartan protects endothelial cells against oxidative stress-mediated cellular injury (({{pubmed>​long:​25904217}})) ​ PMID 25904217
  
  
-* decreases viability of malignant cell lines(({{pubmed>​long:​28666209}}))+* decreases viability of malignant cell lines(({{pubmed>​long:​28666209}})) ​ PMID 28666209
  
  
-* carotid IMT and BP decreased similarly with olmesartan and atenolol; but only olmesartan reduced the volume of larger atherosclerotic plaques (({{pubmed>​long:​19124398}}))+* carotid IMT and BP decreased similarly with olmesartan and atenolol; but only olmesartan reduced the volume of larger atherosclerotic plaques (({{pubmed>​long:​19124398}})) ​ PMID 19124398
  
  
-* improvement of Plasma Biomarkers after switching stroke patients from other Angiotensin II Type I Receptor Blockers to Olmesartan (({{pubmed>​long:​25891757}}))+* improvement of Plasma Biomarkers after switching stroke patients from other Angiotensin II Type I Receptor Blockers to Olmesartan (({{pubmed>​long:​25891757}})) ​ PMID 25891757
  
  
-* improvement of glycemic control & insulin resistance was only observed in olmesartan group (({{pubmed>​long:​23303198}}))+* improvement of glycemic control & insulin resistance was only observed in olmesartan group (({{pubmed>​long:​23303198}})) ​ PMID 23303198
  
  
-* OLM substantially delayed the development of left ventricular remodeling in type 2 diabetes (({{pubmed>​long:​25275251}}))+* OLM substantially delayed the development of left ventricular remodeling in type 2 diabetes (({{pubmed>​long:​25275251}})) ​ PMID 25275251
  
  
-* prevention of microalbuminuria in patients with type 2 diabetes and hypertension (({{pubmed>​long:​22418908}}))+* prevention of microalbuminuria in patients with type 2 diabetes and hypertension (({{pubmed>​long:​22418908}})) ​ PMID 22418908
  
  
-Recent studies showed treatment with olmesartan inhibited bone loss (({{pubmed>​long:​25363367}})), ​+Recent studies showed treatment with olmesartan inhibited bone loss (({{pubmed>​long:​25363367}})), ​  PMID 25363367
  
  
-olmesartan protects endothelial cells against oxidative stress-mediated cellular injury (({{pubmed>​long:​25904217}})), ​+olmesartan protects endothelial cells against oxidative stress-mediated cellular injury (({{pubmed>​long:​25904217}})), ​  PMID 25904217
  
  
-decreases viability of malignant cell lines (({{pubmed>​long:​28666209}})), ​+decreases viability of malignant cell lines (({{pubmed>​long:​28666209}})), ​  PMID 28666209
  
  
 carotid IMT and BP decreased similarly with olmesartan and atenolol; but only olmesartan reduced ​ carotid IMT and BP decreased similarly with olmesartan and atenolol; but only olmesartan reduced ​
-the volume of larger atherosclerotic plaques (({{pubmed>​long:​19124398}})),​+the volume of larger atherosclerotic plaques (({{pubmed>​long:​19124398}})), ​ PMID 19124398
  
  
-improvement of Plasma Biomarkers after switching stroke patients from other Angiotensin II Type I Receptor Blockers to Olmesartan (({{pubmed>​long:​25891757}})),​+improvement of Plasma Biomarkers after switching stroke patients from other Angiotensin II Type I Receptor Blockers to Olmesartan (({{pubmed>​long:​25891757}})), ​ PMID 25891757
  
  
-improvement of glycemic control & insulin resistance was only observed in olmesartan group (({{pubmed>​long:​23303198}})),​+improvement of glycemic control & insulin resistance was only observed in olmesartan group (({{pubmed>​long:​23303198}})), ​ PMID 23303198
  
  
-OLM substantially delayed the development of left ventricular remodeling in type 2 diabetes (({{pubmed>​long:​25275251}}))+OLM substantially delayed the development of left ventricular remodeling in type 2 diabetes (({{pubmed>​long:​25275251}})) ​ PMID 25275251
  
  
-Long term treatment Data suggest 40 & 80 mg olmesartan are able to significantly remodel & destiffen the arterial wall material during long-term treatment, partly independently of blood pressure, compared with 20 mg. hyper.ahajournals.org/​content/​early/​2014/​07/​07/​HYPERTENSIONAHA.114.03282.reprint (({{pubmed>​long:​25001274}})) ​+Long term treatment Data suggest 40 & 80 mg olmesartan are able to significantly remodel & destiffen the arterial wall material during long-term treatment, partly independently of blood pressure, compared with 20 mg. hyper.ahajournals.org/​content/​early/​2014/​07/​07/​HYPERTENSIONAHA.114.03282.reprint (({{pubmed>​long:​25001274}})) ​  PMID 25001274
  
  
home/starting/physician/reluctant.txt · Last modified: 04.15.2019 by sallieq
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