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home:symptoms:neurological:fatigue [02.09.2019] – [Management of fatigue] sallieqhome:symptoms:neurological:fatigue [09.14.2022] (current) – external edit 127.0.0.1
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-<relatedarticles>   [[home:diseases:anemia|Anemia]], [[home:diseases:cfs|Chronic fatigue syndrome]]</article>+<relatedarticles>   [[home:diseases:anemia|Anemia]], [[home:diseases:cfs|Chronic fatigue syndrome]], [[home:othertreatments:thyroid_hormones#research|Thyroid hormone and mineral supplementation]]</article> 
  
 ====== Introduction ====== ====== Introduction ======
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 ===== Inflammation causes fatigue ===== ===== Inflammation causes fatigue =====
  
-The hallmark of chronic diseases is inflammation, the body's response to infection. Inflammation plays an increasingly well-defined role in fatigue.(({{pubmed>long:18793712}}))+The hallmark of chronic diseases is inflammation, the body's response to infection. Inflammation plays an increasingly well-defined role in fatigue.(({{pmid>long:18793712}}))
  
-For example, most researchers believe that the fatigue so common in patients with multiple sclerosis, a typical Th1 disease, is caused by inflammatory cytokines such as TNF-alpha and interferon gamma that go along with elevated 1,25-D. One study found that TNF-alpha values significantly correlated with daytime sleepiness as measured by the Epworth Sleepiness Scale. Controlling for disease activity (as measured by the Cambridge Multiple Sclerosis Basic Score), disease duration, Expanded Disability Status Scale, and depression further increased the correlation of cytokine production and fatigue.(({{pubmed>long:16361589}})) +For example, most researchers believe that the fatigue so common in patients with multiple sclerosis, a typical Th1 disease, is caused by inflammatory cytokines such as TNF-alpha and interferon gamma that go along with elevated 1,25-D. One study found that TNF-alpha values significantly correlated with daytime sleepiness as measured by the Epworth Sleepiness Scale. Controlling for disease activity (as measured by the Cambridge Multiple Sclerosis Basic Score), disease duration, Expanded Disability Status Scale, and depression further increased the correlation of cytokine production and fatigue.(({{pmid>long:16361589}})) 
  
  
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 ==== Virtues of fatigue ===== ==== Virtues of fatigue =====
  
-From an evolutionary perspectives, the fatigue caused by inflammation may benefit a person. Andrew Miller of Emory University School of Medicine states in [[http://www.newscientist.com/article/dn19953-infectious-moods-a-depressing-side-effect.html|New Scientist]] that "cytokines are trying to shut your body down so that you can devote your resources to healing." In a 2009 paper, he goes on to conclude that fatigue is part of healing:+From an evolutionary perspectives, the fatigue caused by inflammation may benefit a person. Andrew Miller of Emory University School of Medicine states in [[https://www.newscientist.com/article/dn19953-infectious-moods-a-depressing-side-effect.html|New Scientist]] that "cytokines are trying to shut your body down so that you can devote your resources to healing." In a 2009 paper, he goes on to conclude that fatigue is part of healing:
  
 <blockquote>Taken together, these effects of cytokines on the brain and behavior appear to subserve competing evolutionary survival priorities that promote reduced activity to allow healing, and hypervigilance to protect against future attack. <blockquote>Taken together, these effects of cytokines on the brain and behavior appear to subserve competing evolutionary survival priorities that promote reduced activity to allow healing, and hypervigilance to protect against future attack.
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-Increased energy consumption by immune cells requires a metabolic adaptation of the whole organism. (({{pubmed>long:26427038}}))+Increased energy consumption by immune cells requires a metabolic adaptation of the whole organism. (({{pmid>long:26427038}}))
  
   * **Develop an "energy conservation" program** – Re-define "necessary" and sort out the really important activities from those that can wait. MP patients should pace themselves through the day, saving necessary activities for the time of day when they tend to have more energy. Forego jobs that need not be done every day, such as making beds.    * **Develop an "energy conservation" program** – Re-define "necessary" and sort out the really important activities from those that can wait. MP patients should pace themselves through the day, saving necessary activities for the time of day when they tend to have more energy. Forego jobs that need not be done every day, such as making beds. 
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 In the management of fatigue, [[home:othertreatments:stimulants|stimulants]] such as modafinil (Provigil) and caffeine are not recommended. There is limited data on how exactly stimulants modulate the immune response. In the management of fatigue, [[home:othertreatments:stimulants|stimulants]] such as modafinil (Provigil) and caffeine are not recommended. There is limited data on how exactly stimulants modulate the immune response.
  
-Caffeine ingestion can delay fatigue during exercise, but the mechanisms remain elusive.  (({{pubmed>long:12399249}})) +Caffeine ingestion can delay fatigue during exercise, but the mechanisms remain elusive.  (({{pmid>long:12399249}})) 
    
  
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 {{tag>managing symptoms}} {{tag>managing symptoms}}
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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-===== References =====+===== References =====</nodisp> 
home/symptoms/neurological/fatigue.1549746749.txt.gz · Last modified: 02.09.2019 by sallieq
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