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home:symptoms:neurological:fatigue [02.09.2019] – [Management of fatigue] sallieq | home:symptoms:neurological:fatigue [09.14.2022] (current) – external edit 127.0.0.1 | ||
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====== Introduction ====== | ====== Introduction ====== | ||
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===== Inflammation causes fatigue ===== | ===== Inflammation causes fatigue ===== | ||
- | The hallmark of chronic diseases is inflammation, | + | The hallmark of chronic diseases is inflammation, |
- | For example, most researchers believe that the fatigue so common in patients with multiple sclerosis, a typical Th1 disease, is caused by inflammatory cytokines such as TNF-alpha and interferon gamma that go along with elevated 1,25-D. One study found that TNF-alpha values significantly correlated with daytime sleepiness as measured by the Epworth Sleepiness Scale. Controlling for disease activity (as measured by the Cambridge Multiple Sclerosis Basic Score), disease duration, Expanded Disability Status Scale, and depression further increased the correlation of cytokine production and fatigue.(({{pubmed> | + | For example, most researchers believe that the fatigue so common in patients with multiple sclerosis, a typical Th1 disease, is caused by inflammatory cytokines such as TNF-alpha and interferon gamma that go along with elevated 1,25-D. One study found that TNF-alpha values significantly correlated with daytime sleepiness as measured by the Epworth Sleepiness Scale. Controlling for disease activity (as measured by the Cambridge Multiple Sclerosis Basic Score), disease duration, Expanded Disability Status Scale, and depression further increased the correlation of cytokine production and fatigue.(({{pmid> |
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==== Virtues of fatigue ===== | ==== Virtues of fatigue ===== | ||
- | From an evolutionary perspectives, | + | From an evolutionary perspectives, |
< | < | ||
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- | Increased energy consumption by immune cells requires a metabolic adaptation of the whole organism. (({{pubmed> | + | Increased energy consumption by immune cells requires a metabolic adaptation of the whole organism. (({{pmid> |
* **Develop an " | * **Develop an " | ||
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In the management of fatigue, [[home: | In the management of fatigue, [[home: | ||
- | Caffeine ingestion can delay fatigue during exercise, but the mechanisms remain elusive. | + | Caffeine ingestion can delay fatigue during exercise, but the mechanisms remain elusive. |
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{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | ===== References ===== | + | ===== References =====</ |