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home:symptoms:other [01.11.2019] – [Transfusion] sallieqhome:symptoms:other [01.14.2019] – [Member experiences] sallieq
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 ====== Other symptoms     ====== ====== Other symptoms     ======
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 +//links to related articles as follows//  
  
   * [[home:diseases/anemia|anemia]] of chronic disease may be a protection against mycobacterial persistence   * [[home:diseases/anemia|anemia]] of chronic disease may be a protection against mycobacterial persistence
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 ===== Nails ===== ===== Nails =====
  
-Does the disease process or the MP cause hair and/or nail changes? +Does the disease process or the MP cause hair and/or nail changes?  See [[home:symptoms:grayhair#patients_experiences|hair changes]] 
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 +[[https://en.wikipedia.org/wiki/Beau%27s_lines|Sideways lines ]] are a recognised indication of infection. 
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 +Nails are part of the [[https://en.wikibooks.org/wiki/Human_Physiology/Integumentary_System#Nail_Diseases|Integumentary system]] and can be used as described to help in diagnoses of stress and various forms of illness.
  
-Hair loss and hair color loss is very common in Th1 disease (it is made even worse by medications such as prednisone). 
  
  
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-{{tag>symptoms arrange}}+{{tag>symptoms }}
  
 ===== Notes and comments ===== ===== Notes and comments =====
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 Fibrosis Fibrosis
  
-Fibrosis  
  
-When the immune system fails to deal with a pathogen it encases the diseased (infected) tissue in collagen. Angiotensin II is known to accelerate the deposition of collagen into tissue. This is part of the body's immune response. Long-term deposition of collagen leads to fibrosis (falsely called 'scar' tissue).  
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-Deposition of collagen to encase pathogens which have escaped the immune system is one of the last lines of defense of the body.  
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-Autoimmune  
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-…..'autoimmune damage' does not exist, except in the minds of the scientists who study it. It would take a whole conference on the topic to get beyond that simple statement. You can look at my Bio21 lecture for a slide with a little more background on this issue.  
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-There is currently very little known about fibrosis in Sarcoidosis. Since nobody has been healed of the disease (prior to the MP) the scientists have just been guessing at what causes the fibrotic tissue deposition.  
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-Recovery from fibrosis  
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-Medicine will tell you that fibrotic tissue does not remodel, but that is not what we are seeing.  
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-Fibrosis (collagen) is thought to be permanent, but it isn't. In Rheumatoid Arthritis, collagen, especially when under mechanical stress (as it is in the lungs) will resorb, and potentially release some of the diseased tissue.  
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-“I don't think it will be necessary to stop Benicar in order to get cartilage remodeling. I say that because of lesser remodeling of tendons on arms and legs which is occasionally reported by the cohort. I know that Angiotensin II is thought to be key in deposition of fetal cartilage, abut I am not sure that this function is not supplanted later in life. You are correct in expecting it to be at the 5+ year mark into recovery, however…” ..Trevor..  
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-Fibrosis remodelling occurs as the Vitamin D metabolites normalize, for much the same reason as arthritic joints recover during the several years of phase 3.  
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-We have seen no sign in our cohort that the organs cannot heal to restore full function, even though deposited collagen remains in place. The lungs are really good at healing, even though they may be badly scarred from years of fibrosis.  
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-The issue of fibrosis is complex, and we are learning more all the time. But the conventional view that the body cannot heal because of fibrotic tissue is absolutely incorrect. We have proved that. Beyond that statement, only time will tell.  
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-As the body heals (with the MP) the fibrotic tissue will 'remodel' and be replaced by new healthy tissue. We have no data yet on what happens at this point, as nobody has ever recovered from this disease before the MP, and scar tissue was thought to be permanent. We now know that it isn't, that it remodels, but beyond that is still unchartered territory.  
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-This articlesays liver fibrosis is reversible in humans.  
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-Everything heals on the MP, but at differing rates. For example, neuropathy is slower to respond, and fibrosis is very slow. But the body has demonstrated that it can eventually recover from just about everything caused by Th1 inflammation.  
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-We are seeing that fibrosis in kidneys, livers, and lungs slowly remodels after the patient has been returned to health. It is part of the gradual recovery which will creep up on you over many years.  
  
 Folks recovering on the MP need nothing except their returning health. The angiotensin blockade (Benicar) inhibits the formation of new fibrotic tissue. Eventually, a fully-functioning immune system (without antibiotics) will do the job perfectly well.  Folks recovering on the MP need nothing except their returning health. The angiotensin blockade (Benicar) inhibits the formation of new fibrotic tissue. Eventually, a fully-functioning immune system (without antibiotics) will do the job perfectly well. 
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 Dr. Marshall  Dr. Marshall 
  
-Assessing recovery from fibrosis  
  
-Even though you may still be feeling terrible, a CT scan might well show that the lymph nodes are steadily shrinking. Granuloma shrink too, but not those which have been calcified or turned fibrotic.  
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-The PFTs usually improve, particularly the DLco, or gas diffusion capability.  
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-The more fibrotic tissue a patient has accumulated, the more sensible it is for that patient to continue with the MP until all signs of the disease have disappeared.  
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-The immune system kills CWD, not the drugs  
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-Immunopathology (Herxheimer reaction) is to be expected and should not be interpreted as a side effect, adverse reaction or intolerance.  
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-We know that when the immune system is effectively fighting infection, the result is cell death. But this is the road to recovery. It is a mistake to focus on the drugs. It is the immune system that is killing the intracellular bacteria.  
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-The aim of the combined essential elements of the MP (avoiding light and vitamin D, using the MP meds etc) is to stimulate/activate the immune system.  
  
 The innate immune system can work properly when the VDR is not over-stimulated, and the antibiotics are often not necessary to continue the process. The antibiotics do ensure a more even species-kill, and establish a pattern to the response.  The innate immune system can work properly when the VDR is not over-stimulated, and the antibiotics are often not necessary to continue the process. The antibiotics do ensure a more even species-kill, and establish a pattern to the response. 
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 See Cell death (apotosis) must precede cessation of fibrosis.  See Cell death (apotosis) must precede cessation of fibrosis. 
  
-Immunupathology resulting from fibrosis remodeling  
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-If you have significant fibrosis there is reason to expect your immune system will have ongoing low-levels of pathogens to deal with for quite some time.  
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-Also, as the immune system becomes more competent again it has the ability to go after species which it could not deal with during earlier phases of your recovery.  
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-As the fibrotic tissue is remodelled (by the body's own processes) there may be times when many encased pathogens are suddenly released.  
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-As a consequence, patients with extensive pulmonary fibrosis may experience sudden bouts of severe pulmonary immunopathology (which may include extreme SOB).  
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-At any stage along the MP the immune system may become particularly active due to remodeling of fibrosis and need more modulating than stimulating.  
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-Regular doses of antibiotics can be modulatory and may actually reduce your immune response. The regular cycles and meds adjustments may help to make the immune response fit into a predictable pattern.  
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-Pnuemothorax  
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-It is the sarcies who seem most at risk of sudden and/or severe immunopathology, with lots of lung fibrosis.  
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-Those who have severe respiratory disease should be encouraged to keep the oxygen concentrator handy for a year or two into phase 3, out of an abundance of caution .  
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-Sarcoidosis patients often have surgery on their lungs. The open lung biopsy, by thoracotomy, is a very invasive procedure that (thankfully) is not used much any longer. But even bronchoscopy can lacerate the lung tissue a little. This damaged tissue may be the source of previously resistant pathogens which cause this sudden severe immune system response.  
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-Sarcoidosis patients who have had a lung biopsy to be particularly careful of leaks in their lungs, which may occur gradually or suddenly, causing large or small pneumothorax. I had 'an adhesion' in 1989, where the bottom of my right lung stuck to my diaphragm, an extremely painful event. This was at the point where tissue had been removed for the thoracotomy biopsy in 1978. This area has been the site of severe immunopathology.  
  
 See What should I know about respiratory immunopathology?  See What should I know about respiratory immunopathology? 
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 Does the disease process or the MP cause hair and/or nail changes? Does the disease process or the MP cause hair and/or nail changes?
  
-Does the disease process or the MP cause hair and/or nail changes?  
  
-Hair loss and color Hair lossis very common in Th1 disease (it is made even worse by medications such as prednisone).  
  
 Dr Alan Cantwell, MD (dermatologist) reports that the CWD bacteria love sweat glands and hair follicles. Please see Dr. Cantwell's paper at The Eccrine Sweat Gland As A Possible Focus Of Infection With Acid-Fast Cell-Wall-Deficient Bacteria  Dr Alan Cantwell, MD (dermatologist) reports that the CWD bacteria love sweat glands and hair follicles. Please see Dr. Cantwell's paper at The Eccrine Sweat Gland As A Possible Focus Of Infection With Acid-Fast Cell-Wall-Deficient Bacteria 
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 The Mayo Clinic offers information about nail ridges - and a photo - at this link.  The Mayo Clinic offers information about nail ridges - and a photo - at this link. 
  
-Members' experiences  
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-I have noticed that my toenails on both feet are changing. I have had diabetes for 46 years and I have deep ridges in great toes but, the ridges are disappearing and the nails are becoming smoother. I think this is SIGNIFICANT for a long time insulin dependent diabetic. Any one else notice this? I have NEVER heard of this! ~ Debbie Y 
-my fingernails have vertical ridges along with the horizontal ridges - growing out. ~AB 
-The finger nail problems you describe are very common with psoriatic arthritis. My fingernails have looked the way you describe for many years, long before I got sick. Mine aren't so angled as they are wavy. Sometimes these problems are associated with fungus and go away with rather strong medication (that would clearly not be permitted with the protocol). Sometimes people actually lose their nails–simply shed them. I lost one a year ago and to my amazement a perfect one grew back. I'm quite proud of it.Everything about it is perfect. Might be the first small physical improvement I've experienced in several years. ~Jim 
-I'm not exactly sure when mine appeared, but I have many, fine ridges running lengthwise on all my fingernails which are easily felt and seen. I have wondered myself whether or not they may be connected to this illness. Brad has always had some ridges but they are noticibly worse.(very rough) ~Paulette 
-My experience has been that my nail ridges are much less obvious now than pre-MP. Back then, I used to get inflammation and lots of tiny blisters behind my cuticles and then deep ridges in my nails as a result. ~Belinda 
-I've had those ridges in my nails for several years before I got sick. I was in my 20's so I don't think age is the reason. ~CFSgirl 
-I HAVE ALSO NOTICED HEAVY RIDGES OR LINES HAVE APPEARED ALONG THE LENGTH OF MY NAILS,NOT ON THE OUTER EDGES BUT TOWARD THE MIDDLE,MY NAILS SEEM STRONGER AND AT THE SAME TIME FLEXABLE,BUT THE RIDGE RIDDLE I HAVE NO ANSWER TO ~vda51 
-I, too, have ridges in most all of my fingernials. There appears to be no fungal problem. 
-I can remember that I had nice smooth nails when I was younger, before roughly the time when I got bit by my first tick. My ridges developed over much time, slowly. Not really sure when they started. But they certainly showed up as my disease increased in severity. ~Dark Vader (aka, George) 
-I have vertical ridges on my nails that have “worsened” on the MP. Three nails that were ridge-free, are now ridged as well. I don't think it has to do much with aging, unless the aging has to do with intracellular bacteria wreaking havoc in the body. So I'm blaming the ridges on the bacteria in the meantime.  Time will tell…! Alayne 2006 
-Just wanted to say a couple of months later that my nails continue to increasingly ridge. My thumbnails were relatively ridge-free as of my last post here 2 months ago. They've grown quite ridged and uneven since then. Pain free herx?  If vertical ridges were all I had to worry about…what a world it would be!  ~Alayne 
-Yes, my nails were always fine before I became ill with (Hashimoto's) autoimmune thyroiditis. Then suddenly they got very brittle, with deep ridges. I guess it is the lack of thyroid hormone which causes this. I suffered a lot of hair loss which has been reversed with thyroxine, but sadly my nails haven't recovered. I wonder if the MP can fix my nails too?  ~Claudia 
-I can not remember when I had vertical lines on my nails since I always had them I though it was normal. ~Ramzi70 
-I don't think ridges on nails have anything to do with aging either, as I am 27 and have always seemed to have ridges on my nails. They run from the base (cuticle) to the tip of the nail, though sometimes they look slightly cross-hatched, not just straight lines. ~Lantern 
-I noticed this week that the nail ridges have all but disappeared from my right hand and are substantially lessened on my left hand. ~Desert Marie 
-Yes, I have noticed my nails are much stronger. ~Aunt Diana 
-I had to cut my nails recently because they were too long…that's the first time in several years. They would usually break or split. Definitely healthier. ~DNStog 
-I too have fine lines in my nails,, no fungus.~weepingsparrow 
-When I got to Phase 2 of the MP, the ridges disappeared from my fingernails. (I never got to Phase 3 because of moving and the changes from Medicare D, which eliminated my drug coverage from Medicaid, which had formerly paid for Benicar.) Since I have been off the MP for about a year, ridges have returned, worse than before. I just got back on Phase 1 and I expect the ridges will eventually disappear again. ~Lily 
-I too have had these since my teens on each nail; they are pearlized (like tiny little droplets making up the ridges). In my 20s, they would turn purple underneath and become very painful. (But no sign of fungus.) For years now, pre-MP my nails have chipped and broken off before I could cut them, splitting from the side and down the ridges. ~eClaire 
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 ===== References ===== ===== References =====
home/symptoms/other.txt · Last modified: 09.14.2022 by 127.0.0.1
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