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home:symptoms:other [01.14.2019]
sallieq [Notes and comments]
home:symptoms:other [01.14.2019]
sallieq [Member experiences]
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 ====== Other symptoms ​    ​====== ====== Other symptoms ​    ​======
 +
 +//links to related articles as follows//  ​
  
   * [[home:​diseases/​anemia|anemia]] of chronic disease may be a protection against mycobacterial persistence   * [[home:​diseases/​anemia|anemia]] of chronic disease may be a protection against mycobacterial persistence
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 ===== Nails ===== ===== Nails =====
  
-Does the disease process or the MP cause hair and/or nail changes? ​+Does the disease process or the MP cause hair and/or nail changes? ​ See [[home:​symptoms:​grayhair#​patients_experiences|hair changes]] 
 + 
 +[[https://​en.wikipedia.org/​wiki/​Beau%27s_lines|Sideways lines ]] are a recognised indication of infection. 
 + 
 +Nails are part of the [[https://​en.wikibooks.org/​wiki/​Human_Physiology/​Integumentary_System#​Nail_Diseases|Integumentary system]] and can be used as described to help in diagnoses of stress and various forms of illness.
  
-Hair loss and hair color loss is very common in Th1 disease (it is made even worse by medications such as prednisone). 
  
  
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-{{tag>​symptoms ​arrange}}+{{tag>​symptoms }}
  
 ===== Notes and comments ===== ===== Notes and comments =====
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 Fibrosis Fibrosis
  
-Fibrosis ​ 
  
-When the immune system fails to deal with a pathogen it encases the diseased (infected) tissue in collagen. Angiotensin II is known to accelerate the deposition of collagen into tissue. This is part of the body's immune response. Long-term deposition of collagen leads to fibrosis (falsely called '​scar'​ tissue). ​ 
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-Deposition of collagen to encase pathogens which have escaped the immune system is one of the last lines of defense of the body.  
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-Autoimmune ​ 
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-…..'​autoimmune damage'​ does not exist, except in the minds of the scientists who study it. It would take a whole conference on the topic to get beyond that simple statement. You can look at my Bio21 lecture for a slide with a little more background on this issue. ​ 
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-There is currently very little known about fibrosis in Sarcoidosis. Since nobody has been healed of the disease (prior to the MP) the scientists have just been guessing at what causes the fibrotic tissue deposition. ​ 
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-Recovery from fibrosis ​ 
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-Medicine will tell you that fibrotic tissue does not remodel, but that is not what we are seeing. ​ 
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-Fibrosis (collagen) is thought to be permanent, but it isn't. In Rheumatoid Arthritis, collagen, especially when under mechanical stress (as it is in the lungs) will resorb, and potentially release some of the diseased tissue. ​ 
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-“I don't think it will be necessary to stop Benicar in order to get cartilage remodeling. I say that because of lesser remodeling of tendons on arms and legs which is occasionally reported by the cohort. I know that Angiotensin II is thought to be key in deposition of fetal cartilage, abut I am not sure that this function is not supplanted later in life. You are correct in expecting it to be at the 5+ year mark into recovery, however…” ..Trevor.. ​ 
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-Fibrosis remodelling occurs as the Vitamin D metabolites normalize, for much the same reason as arthritic joints recover during the several years of phase 3.  
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-We have seen no sign in our cohort that the organs cannot heal to restore full function, even though deposited collagen remains in place. The lungs are really good at healing, even though they may be badly scarred from years of fibrosis. ​ 
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-The issue of fibrosis is complex, and we are learning more all the time. But the conventional view that the body cannot heal because of fibrotic tissue is absolutely incorrect. We have proved that. Beyond that statement, only time will tell.  
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-As the body heals (with the MP) the fibrotic tissue will '​remodel'​ and be replaced by new healthy tissue. We have no data yet on what happens at this point, as nobody has ever recovered from this disease before the MP, and scar tissue was thought to be permanent. We now know that it isn't, that it remodels, but beyond that is still unchartered territory. ​ 
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-This articlesays liver fibrosis is reversible in humans. ​ 
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-Everything heals on the MP, but at differing rates. For example, neuropathy is slower to respond, and fibrosis is very slow. But the body has demonstrated that it can eventually recover from just about everything caused by Th1 inflammation. ​ 
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-We are seeing that fibrosis in kidneys, livers, and lungs slowly remodels after the patient has been returned to health. It is part of the gradual recovery which will creep up on you over many years. ​ 
  
 Folks recovering on the MP need nothing except their returning health. The angiotensin blockade (Benicar) inhibits the formation of new fibrotic tissue. Eventually, a fully-functioning immune system (without antibiotics) will do the job perfectly well.  Folks recovering on the MP need nothing except their returning health. The angiotensin blockade (Benicar) inhibits the formation of new fibrotic tissue. Eventually, a fully-functioning immune system (without antibiotics) will do the job perfectly well. 
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 Dr. Marshall ​ Dr. Marshall ​
  
-Assessing recovery from fibrosis ​ 
  
-Even though you may still be feeling terrible, a CT scan might well show that the lymph nodes are steadily shrinking. Granuloma shrink too, but not those which have been calcified or turned fibrotic. ​ 
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-The PFTs usually improve, particularly the DLco, or gas diffusion capability. ​ 
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-The more fibrotic tissue a patient has accumulated,​ the more sensible it is for that patient to continue with the MP until all signs of the disease have disappeared. ​ 
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-The immune system kills CWD, not the drugs  
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-Immunopathology (Herxheimer reaction) is to be expected and should not be interpreted as a side effect, adverse reaction or intolerance. ​ 
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-We know that when the immune system is effectively fighting infection, the result is cell death. But this is the road to recovery. It is a mistake to focus on the drugs. It is the immune system that is killing the intracellular bacteria. ​ 
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-The aim of the combined essential elements of the MP (avoiding light and vitamin D, using the MP meds etc) is to stimulate/​activate the immune system. ​ 
  
 The innate immune system can work properly when the VDR is not over-stimulated,​ and the antibiotics are often not necessary to continue the process. The antibiotics do ensure a more even species-kill,​ and establish a pattern to the response. ​ The innate immune system can work properly when the VDR is not over-stimulated,​ and the antibiotics are often not necessary to continue the process. The antibiotics do ensure a more even species-kill,​ and establish a pattern to the response. ​
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 See Cell death (apotosis) must precede cessation of fibrosis. ​ See Cell death (apotosis) must precede cessation of fibrosis. ​
  
-Immunupathology resulting from fibrosis remodeling ​ 
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-If you have significant fibrosis there is reason to expect your immune system will have ongoing low-levels of pathogens to deal with for quite some time.  
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-Also, as the immune system becomes more competent again it has the ability to go after species which it could not deal with during earlier phases of your recovery. ​ 
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-As the fibrotic tissue is remodelled (by the body's own processes) there may be times when many encased pathogens are suddenly released. ​ 
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-As a consequence,​ patients with extensive pulmonary fibrosis may experience sudden bouts of severe pulmonary immunopathology (which may include extreme SOB).  
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-At any stage along the MP the immune system may become particularly active due to remodeling of fibrosis and need more modulating than stimulating. ​ 
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-Regular doses of antibiotics can be modulatory and may actually reduce your immune response. The regular cycles and meds adjustments may help to make the immune response fit into a predictable pattern. ​ 
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-Pnuemothorax ​ 
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-It is the sarcies who seem most at risk of sudden and/or severe immunopathology,​ with lots of lung fibrosis. ​ 
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-Those who have severe respiratory disease should be encouraged to keep the oxygen concentrator handy for a year or two into phase 3, out of an abundance of caution .  
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-Sarcoidosis patients often have surgery on their lungs. The open lung biopsy, by thoracotomy,​ is a very invasive procedure that (thankfully) is not used much any longer. But even bronchoscopy can lacerate the lung tissue a little. This damaged tissue may be the source of previously resistant pathogens which cause this sudden severe immune system response. ​ 
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-Sarcoidosis patients who have had a lung biopsy to be particularly careful of leaks in their lungs, which may occur gradually or suddenly, causing large or small pneumothorax. I had 'an adhesion'​ in 1989, where the bottom of my right lung stuck to my diaphragm, an extremely painful event. This was at the point where tissue had been removed for the thoracotomy biopsy in 1978. This area has been the site of severe immunopathology. ​ 
  
 See What should I know about respiratory immunopathology? ​ See What should I know about respiratory immunopathology? ​
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 Does the disease process or the MP cause hair and/or nail changes? Does the disease process or the MP cause hair and/or nail changes?
  
-Does the disease process or the MP cause hair and/or nail changes? ​ 
  
-Hair loss and color Hair lossis very common in Th1 disease (it is made even worse by medications such as prednisone). ​ 
  
 Dr Alan Cantwell, MD (dermatologist) reports that the CWD bacteria love sweat glands and hair follicles. Please see Dr. Cantwell'​s paper at The Eccrine Sweat Gland As A Possible Focus Of Infection With Acid-Fast Cell-Wall-Deficient Bacteria ​ Dr Alan Cantwell, MD (dermatologist) reports that the CWD bacteria love sweat glands and hair follicles. Please see Dr. Cantwell'​s paper at The Eccrine Sweat Gland As A Possible Focus Of Infection With Acid-Fast Cell-Wall-Deficient Bacteria ​
home/symptoms/other.txt · Last modified: 07.05.2019 by sallieq
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