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--- home:tests:lipids [01.03.2012] – external edit 127.0.0.1
+++ home:tests:lipids [04.16.2015] – [Atherosclerosis] joyful
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   * **Some angiographic studies show that cholesterol is //inversely// associated with atherosclerosis** – In two of five angiographic (x-rays of blood vessels) studies, there was an inverse association between change of total cholesterol and atherosclerotic growth.(({{pubmed>long:12037248}}))
-  * **Diets intended to lower cholesterol do not lead to atherosclerosis** – In 2006, the Cochrane Collaboration published an update of a systematic review that analyzed 10 of the most rigorous studies to test the ability of "multiple risk factor interventions" (i.e. diets in low saturated fat, smoking cessation, etc.) to prevent cardiovascular disease. Together the trials accounted for around 900,000 patients, many of which were followed over the course of several years. The analysis found that interventions designed to lower risk factors for cardiovascular disease such as diet counseling were ineffective: "The pooled effects suggest multiple risk factor intervention has no effect on mortality.... The evidence suggests that such interventions have limited utility in the general population."(({{pubmed>long:17054138}})) In the only clinical trial of the effect of diets high in unsaturated fats on atherosclerosis that included a post-mortem, complicated atherosclerosis was most pronounced in the treatment group.((Dayton DF Pearce ML Hashimoto MS Dixon WJ Tomiyasu U [[http://circ.ahajournals.org/cgi/content/abstract/circulationaha;40/1S2/II-1|A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis]] //Circulation//. 1969;40:II-1.))
+  * **Diets intended to lower cholesterol do not lead to reduced atherosclerosis** – In 2006, the Cochrane Collaboration published an update of a systematic review that analyzed 10 of the most rigorous studies to test the ability of "multiple risk factor interventions" (i.e. diets in low saturated fat, smoking cessation, etc.) to prevent cardiovascular disease. Together the trials accounted for around 900,000 patients, many of which were followed over the course of several years. The analysis found that interventions designed to lower risk factors for cardiovascular disease such as diet counseling were ineffective: "The pooled effects suggest multiple risk factor intervention has no effect on mortality.... The evidence suggests that such interventions have limited utility in the general population."(({{pubmed>long:17054138}})) In the only clinical trial of the effect of diets high in unsaturated fats on atherosclerosis that included a post-mortem, complicated atherosclerosis was most pronounced in the treatment group.((Dayton DF Pearce ML Hashimoto MS Dixon WJ Tomiyasu U [[http://circ.ahajournals.org/cgi/content/abstract/circulationaha;40/1S2/II-1|A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis]] //Circulation//. 1969;40:II-1.))

home/tests/lipids.txt · Last modified: 09.14.2022 by 127.0.0.1