Fish oil and omega 3 fatty acids

Because omega 3 essential fatty acids have been shown to contain components that slow immune activity, Marshall Protocol (MP) patients should avoid consuming them.

• cod liver oil
• fish oil
• flax seed oil

All supplemental oils may contain vitamin D, the consumption of which is contraindicated for MP patients.

One of the sarcoidosis patients wrote to the manufacturer and was told that Primrose Oil has a significant quantity of Vitamin D in it. An excessive quantity, in fact. Enough to disable the immune system from killing the L-form bacteriaDifficult-to-culture bacteria that lack a cell wall and are not detectable by traditional culturing processes. Sometimes referred to as cell wall deficient bacteria..

In my opinion, you don't need essential fatty acids. You need to throw off your Th1 diseaseAny of the chronic inflammatory diseases caused by bacterial pathogens.. When you are healthy again you will not be interested in (or need) any of these supplements.

Trevor Marshall, PhD

Greater consumption of omega 3's has been shown to reduce inflammationThe complex biological response of vascular tissues to harmful stimuli such as pathogens or damaged cells. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. and immune activity.¹⁾

• Omega 3's contain components which suppress TNF-alphaA cytokine critical for effective immune surveillance and is required for proper proliferation and function of immune cells. – CytokinesAny of various protein molecules secreted by cells of the immune system that serve to regulate the immune system. are regulatory proteins, such as TNF-alpha, that are released by cells of the immune system and act as intercellular mediators in the generation of an immune response. The omega 3 fatty acids, for example, contain several components which may interfere with the activity of TNF-alpha and other important cytokines.

Arachidonic acid (AA) significantly decreased TNFalpha production…. The results show that docosahexaenoic acid (DHA) induces a Th-1-like immune response and that AA has anti-inflammatory effects by decreasing the production of TNFalpha. Thus, the immune effects of omega3 polysaturated fatty acids are not compatible with what is expected from antidepressive substances. The results of the present study show that treatment with fish oils, containing DHA, should be avoided in the treatment of depression. Toward this end, highly concentrated and pure EPA seems to be indicated.

M. Maes et al ²⁾

• EPA and DHA were shown in a controlled trial to reduce immune activity. EPA and DHA are present in fish oil in significant quantities.

A high eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake changed the expression of 1,040 genes…. EPA+DHA intake resulted in a decreased expression of genes involved in inflammatory- and atherogenic-related pathways, such as nuclear transcription factor kappaB signaling, eicosanoid synthesis, scavenger receptor activity, adipogenesis, and hypoxia signaling.

M. Bouwens ³⁾

• EPA and DHA switch off a key receptor responsible for innate immunityThe body's first line of defense against intracellular and other pathogens. According to the Marshall Pathogenesis the innate immune system becomes disabled as patients develop chronic disease. in fat cells. Olefsky and colleagues identified a key receptor on macrophages abundantly found in obese body fat: the GPR120 receptor.⁴⁾ The team showed that omega-3 fatty acids activate this macrophage receptor, resulting in broad anti-inflammatory effects. Commenting about his work, Olefsky said, “It's just an incredibly potent effect. The omega-3 fatty acids switch on the receptor, killing the inflammatory response.”

• Fish oil-fed mice have impaired resistance to influenza infection.

Although fish oil-fed mice had lower lung inflammation compared with controls, fish oil feeding also resulted in a 40% higher mortality rate, a 70% higher lung viral load at d 7 post infection, and a prolonged recovery period following infection…. Additionally, lungs of infected fish oil-fed mice had significantly fewer CD8+ T cells and decreased mRNA expression of macrophage inflammatory protein-1-alpha, tumor necrosis factor-alphaA cytokine critical for effective immune surveillance and is required for proper proliferation and function of immune cells., and interleukin-6. These results suggest that the antiinflammatory properties of fish oil feeding can alter the immune response to influenza infection, resulting in increased morbidity and mortality.

Schwerbrock et al.⁵⁾

• Mice given omega‐3's are more susceptible to pulmonary tuberculosis – Bonilla et al. showed that transgenic mice engineered to produce omega-3's endogenously (internally) increased their susceptibility to tuberculosis, which they explained by noting the corresponding reduction in antimycobacterial responses in cells. The researchers concluded, “These data suggest that n‐3 PUFA–supplemented [dietary omega‐3 fatty acids] diets might have a detrimental effect on immunity to M. tuberculosis and raise concerns regarding the safety of omega‐3 dietary supplementation in humans.”⁶⁾