| Author/year | study design | |
|---|---|---|
| Steven R. Cummings, MD; Douglas P. Kiel, MD, MPH; Dennis M. Black, PhD, 2016 6) | Two “high” doses (60 000 IU of vitamin D3Form of vitamin D made in the skin when exposed to light. Also available in fish and meat. This secosteroid is sometimes converted into 25-D. Also known as cholecalciferol and activated 7-dehydrocholesterol. per month or 24 000 IU vitamin D3 plus 300 mg of calcifediol per month) achieved a serum 25-hydroxyvitamin D (25[OH]D) level of 30 ng/mL in 80% of participants, a level that has been recommended as best for reducing the risk of fractures | compared with a dose of 24 000 IU of vitamin D3 per month (equivalent to 800 IU per day), the higher doses had no effect on lower extremity physical performance and increased the risk of falls. |
| Karen E. Hansen, MD, MS; R. Erin Johnson, BS; Kaitlin R. Chambers, BS et al., 2015 7) | randomized, double-blind, placebo-controlled clinical trial from May 1, 2010, through July 31, 2013, and final visit on August 8, 2014. A total of 230 postmenopausal women 75 years or younger with baseline 25(OH)D levels of 14 through 27 ng/mL and no osteoporosis were studied. | “We found that compared with placebo, high-dose cholecalciferol had a very small effect on calcium absorption (1%) that did not translate into meaningful changes in lumbar spine, mean total-hip, femoral neck, or total-body BMD, trabecular bone score, TUG score, STS test score, muscle mass, number of falls, or number of fallers. ” |
Summary - still in OSTEOPENIA category,
but increased density for both femurs and spine
year where bmd t-score z-score
(young adult) (age-matched)
2007 L1-L4 1.058 87% -1.3 87% -1.3 2009 L1-L4 1.153 94% -0.5 96% -0.4 2014 L1-L4 1.178 97% -0.4 99% -0.1 2016 L1-L4 1.255 0.3 0.7
2007 left femur neck 0.870 81% -1.5 88% -0.9 2009 left femur neck 0.928 87% -1.1 98% -0.3 2014 left femur neck 0.976 97% -0.4 103% -0.2 2016 left femur neck 1.033 97% -0.3 103% 0.8
2007 right femur neck 0.777 73% -2.3 79% -1.6 2009 right femur neck 0.862 81% -1.6 98% -0.8 2014 right femur neck 0.794 -2.1 -1.2 2016 right femur neck 0.821 -1.9 -0.8
(BMD = bone mass density in gm/cm3)
2016 % change from most recent Spine 6.4% Left femur neck 5.8% right femur neck 3.4%
| year | where | bmd | t-score | z-score |
|---|---|---|---|---|
| year | where | bmd | t-score | z-score |
| year | where | bmd | t-score | z-score |
| 2007 | L1-L4 | 1.058 | 87% -1.3 | 87% -1.3 |
| 2009 | L1-L4 | 1.153 | 94% -0.5 | 96% -0.4 |
| 2014 | L1-L4 | 1.178 | 97% -0.4 | 99% -0.1 |
| 2016 | L1-L4 | 1.255 | 0.3 | 0.7 |
| year | where | bmd | t-score | z-score |
|---|---|---|---|---|
| 2007 | L1-L4 | 1.058 | 87% -1.3 | 87% -1.3 |
| 2009 | L1-L4 | 1.153 | 94% -0.5 | 96% -0.4 |
| 2014 | L1-L4 | 1.178 | 97% -0.4 | 99% -0.1 |
| 2016 | L1-L4 | 1.255 | 0.3 | 0.7 |
| 2007 | left femur neck | 0.870 | 81% -1.5 | 88% -0.9 |
| 2009 | left femur neck | 0.928 | 87% -1.1 | 98% -0.3 |
| 2014 | left femur neck | 0.976 | 97% -0.4 | 103% -0.2 |
| 2016 | left femur neck | 1.033 | 97% -0.3 | 103% 0.8 |
| 2007 | right femur neck | 0.777 | 73% -2.3 | 79% -1.6 |
| 2009 | right femur neck | 0.862 | 81% -1.6 | 98% -0.8 |
| 2014 | right femur neck | 0.794 | -2.1 | -1.2 |
| 2016 | right femur neck | 0.821 | -1.9 | -0.8 |
| 2016 | |
|---|---|
| Spine | 6.4% |
| Left femur neck | 5.8% |
| right femur neck | 3.4% |