Diseases associated with low levels of 25-D

According to the Marshall PathogenesisA description for how chronic inflammatory diseases originate and develop., chronic inflammatory disease is caused by a microbiotaThe bacterial community which causes chronic diseases - one which almost certainly includes multiple species and bacterial forms. of pathogens which interfere with proper functioning of the innate immune system. Patients suffering from inflammatory diseases have been shown to have lower than normal levels of 25-hydroxyvitamin D, and there are at least several reasons why bacterial pathogens generate this response.

A full understanding of vitamin D metabolism supports the conclusion that elevated 1,25-D and depressed 25-D are a result rather than a cause of the inflammatory process.

Lower than normal levels of 25-D have been independently associated both with all-cause mortality1) 2) and a number of chronic inflammatory diseases. The following selection of diseases (and patient groups) have been observed to display the hallmarks of this kind of dysregulated vitamin D metabolism.

Anomalies

Both lower and higher levels of 25-D are associated with increased mortality. This 2012 study analyzed blood serum from 247,574 Danish subjects and found a reverse J-curve for mortality.

===== Notes and comments =====

Sallie Q 09.16.2016 added 2016 report on U-shape curve high up on list of anomalies

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