Dosing and administration
Allergies to sulfa medications?
Combining Bactrim with other Marshall Protocol antibiotics
Typical targets for immunopathology
References

Bactrim DS (co-trimoxazole)

Bactrim DS is an antibiotic used by patients on the Marshall Protocol (MP). Bactrim is a combination of two antibiotics, trimethoprim and sulfamethoxazole. This antibiotic combination is thought to work synergistically by inhibiting several steps in the process by which bacteria synthesize folate for their use.

Bactrim DS is the brand name. It is also known as Septra, Sulfatrim, Cotrim, Novo-Trimel, Nu-Cotrimox, Resprim, Roubac and Septrin. The generic name is co-trimoxazole.

Bactrim DS has a reputation for targeting the bacteria in the gastrointestinal tract. Either generic or brand name is appropriate to use.

Dosing and administration

Allergies to sulfa medications?

Many patients with Th1 inflammation have been told that they are allergic to sulfa preparations. This “allergic” reaction experienced in the past was most likely an immunopathological reaction.

These patients should begin with 1/4 tablet (or less) of regular strength Bactrim and ramp up by 1/4 increments every two weeks (or as symptoms allow) to a full tablet. Then, they should progress to Bactrim DS. Cutaneous reactions such as pruritus and rash are common and may be treated palliatively.

A complete blood count (CBC) with differential will help identify those very few patients who may develop a rapid drop in red blood cells (RBC), which would require lowering of the Bactrim dosage.

Combining Bactrim with other Marshall Protocol antibiotics

Bactrim is taken every other day with the dose of minocycline/demeclocycline.

In later stages of the treatments, Bactrim DS may be combined with other MP antibiotics in the following fashion:

BCD – Bactrim DS + clindamycin + demeclocycline
BCM – Bactrim DS + clindamycin + minocycline
BDM – Bactrim DS + demeclocycline + minocycline
BDZ – Bactrim DS + demeclocycline + Zithromax
BMZ – Bactrim DS + minocycline + Zithromax

Typical targets for immunopathology

Bactrim is sometimes prescribed for the non-MP application of traveler's diarrhea. Patients on the MP have reported stronger gastrointestinal immunopathology (IP) when taking Bactrim. Other commonly reported IP include increased fatigue and skin symptoms.

Keywords: antibiotics

Notes and comments

Legacy content

From Trevor (include this in methotrexate and folic acid articles?):

Folic Acid is already on our list of foods to minimize, as it is an essential part of the nutrition for some families of bacteria (your body needs some folate, but it is added to most bread and flour these days)

In fact the drug Methotrexate, one of the most prescribed drugs for chronic inflammatory conditions, is an antibiotic which knocks-out the Folate metabolism by blocking the bacterial DHFR receptor. However, it also blocks the human DHFR, which is not a good thing at all

The drug Trimethoprim, one of our Phase 3 antibiotics (Bactrim is a mixture of Sulfamethoxazole and Trimethoprim), also blocks the bacterial DHFR receptor, but does not block the human DHFR receptor. Altogether a better solution A picture of DHFR from E.coli with Trimethoprim bound into it is shown below:

References

Last modified: 01.02.2012