Vitamin D metabolite calculator

Recent research, including work done by the Autoimmunity Research FoundationNon-profit foundation dedicated to exploring a pathogenesis and therapy for chronic disease. research team, has shown that the Vitamin D nuclear receptor plays a key role in chronic and inflammatory disease. The VDRThe Vitamin D Receptor. A nuclear receptor located throughout the body that plays a key role in the innate immune response.'s transcription of genes is controlled in turn by the Vitamin D metabolism, which is progressively inhibited as the Th1 metagenomic microbiotaThe community of bacterial pathogens including those in an intracellular and biofilm state which cause chronic disease. gradually accumulates in the body's nucleated cells.

Below is an algorithm which will give physicians insight into how the most common Vitamin D metabolites can indicate disease status. This interpretation is not intended as any form of medical diagnosis; the physician must also take into account the general patient presentation and workup, and other objective measures of illness. This algorithm is based on research published in several papers and presentations.^{1 2 3 4 5}

The primary mechanism depressing 25-D levels below 14ng/ml is Th1 inflammation. The 25-D metabolism will be driven to even lower values as the inflammation becomes more widespread. Conversely, the presence of ingested Vitamin D from milk, food, and supplements will counteract this trend. Assessment of the degree of inflammation involves assessment of both the sources of ingestion and the measured 25-D level.

This level of 25-D is in the therapeutic range. This is a good place from which to initiate therapy concomitant with continued avoidance of ingested Vitamin D.