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Welcome to the MPKB

Created by Prof. Trevor Marshall, The Marshall Protocol is a therapy for chronic inflammatory diseases. It is based on an explanation for how an infectious cascade of pathogens slow the immune response, allowing subsequent infections to proliferate, thereby causing the symptoms and markers of disease.

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For Patients

Why microbes may cause chronic inflammatory diseases
What is the Marshall Protocol? – The cornerstone of the MP is frequent dosing of olmesartan (brand name Benicar), which stimulates the innate immune response.
- Introduction
- Length – may take several years depending on how sick a patient is
- Cost – insurance often pays for certain basic expenses; drugs can be ordered online at a discount
- Palliative vs. curative treatments – many widely used treatments and supplements such as vitamin D compromise the immune response to microbes and are therefore contraindicated
Considering the Marshall Protocol
- Therapeutic probe – best method for determining suitability of the Protocol
- Vitamin D Metabolite Calculator – get automated feedback on vitamin D blood tests
- Patient interviews
Starting the treatment – Overview | Checklist
Physicians – Finding a physician | Working with a physician
The Protocol – In-depth overview of the Protocol | Translations of this and other articles
- Immunopathology – temporary increase in disease symptoms experienced by MP patients that is the result of microbial death; appears to be necessary for recovery
- Managing immunopathology – certain strategies are helpful including lowering antibiotics and adjusting olmesartan
- Light restriction – patients who are photosensitive on the MP become less symptomatic when they limit skin exposure to light when outdoors, and skin and eye exposure when indoors
- Food & drink – patients limit vitamin D
- Other treatments – patients only take other medications that offer needed relief from intolerable symptoms
Learn more
- Site map – contains a list of all articles in the KB
- Publications and presentations
- Glossary of terms

For Physicians

The Marshall Pathogenesis – an explanation for how microbes may cause chronic inflammatory diseases
- Science behind Pathogenesis
- Successive infection and variability in disease
- Transmission of bacteria and onset of disease
- Diseases – articles about microbes' role in a given chronic disease; note: many are works in progress
- Evidence that chronic disease is caused by pathogens
- Science behind vitamin D | Metabolism of vitamin D and the Vitamin D Receptor
What is the Marshall Protocol? – The cornerstone of the MP is frequent dosing of olmesartan (brand name Benicar), which stimulates the innate immune response.
- Marshall Protocol – one-page summary of the MP geared towards physicians
- Physicians' concerns – olmesartan, antibiotics, light, vitamin D, immunopathology, clinical evidence
- Olmesartan (Benicar) – Safety of olmesartan | Olmesartan and kidney disease
- Antibiotics – Pulsed low-dose antibiotics | Safety
- Therapeutic probe – best method for determining suitability of the Protocol
- Immunopathology – also known as the Jarisch-Herxheimer reaction
- Managing immunopathology – certain strategies are helpful including lowering antibiotics and adjusting olmesartan
- Other treatments – patients only take other medications that offer needed relief from intolerable symptoms
- Notice for emergency
Alternative models for chronic disease
Learn more
- Resources for physicians
- Publications and presentations
- Diseases – articles about microbes' role in a given chronic disease; note: many are works in progress
- Glossary of terms
- Site map – contains a list of all articles in the KB

News and highlights

Publications and presentations

The human microbiome and autoimmunity - paper in Current opinion in rheumatology which reviews the role of chronic pathogens in “autoimmune” conditions

Immunostimulation in the era of the human metagenome - paper in Molecular and clinical immunology that reviews a case series of Marshall Protocol patients and discusses how immunostimulatory approaches may require rethinking medicine

Autoimmune disease and the human metagenome - book chapter in Springer's Metagenomics of the human body that discusses how the process of successive infection may be responsible for autoimmune disease

The microbiome, which feeds a myriad of autoimmune diseases – presentation by Trevor Marshall, PhD at International Congress on Autoimmunity

Treatment of chronic fatigue syndrome as an immune disorder – presentation by Inge Lindseth at International Congress on Autoimmunity

→ Complete list

About the MPKB Project

The MPKB currently contains about 400 pages and draws from the best possible evidence to support its mission. As of May 2011, about 85% of those articles are complete with the remainder scheduled to be completed.

About Autoimmunity Research Foundation

Autoimmunity Research Foundation is a California-based 501©3 (tax deductible) non-profit formed to educate the public about the nature of, and study a treatment for, chronic inflammatory disease.

History and timeline of the Autoimmunity Research Foundation

Last modified: 02.07.2013