Lupus (SLE/systemic lupus erythematosus)

http://pediatrics.aappublications.org/cgi/content/extract/101/5/926

Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree.

Sestak AL, Shaver TS, Moser KL, Neas BR, Harley JB. University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA. OBJECTIVE: To evaluate an unusual pedigree with 8 members diagnosed with systemic lupus erythematosus (SLE) METHODS: Pedigree members were evaluated through questionnaires, interviews, and medical records. Sixty members contributed serum samples for autoantibody analysis. RESULTS: The 8 affected females shared several disease features, including arthritis (8/8), antinuclear antibodies (ANA) (8/8), pleuritis (6/8), malar rash (6/8), photosensitivityAbnormal sensitivity to sunlight and bright lights. Also referred to as "sun flare" or "light flare." (5/8), and nephritis (4/8). A total of 15 of 51 (29%) blood relatives had autoantibodies; 9 had autoimmune disease, including 7 with SLE, one with psoriasis, and one with Sjögren's syndrome. Five of 11 (45%) nonconsanguineous spouses also had autoantibodies; one spouse had SLE, and 2 others had thyroid disease. Among 68 spouses of patients with SLE in other pedigrees, only 9 (13%) had autoantibodies, and none were symptomatic (p = 0.02). CONCLUSION: The high rate of autoimmunity among both blood relatives and nonconsanguineous mates in this unusual pedigree suggests a complex interaction of genetic and environmental factors contributing to disease. PMID: 10405936

Sample PubMed cite¹

Does minocyclineBacteriostatic antibiotic used by Marshall Protocol patients. have side effects or cause lupus?

The reports that Minocycline can induce lupus are laughable. Exactly how does a complex immune disease arise from the actions of a bacteriostatic antibiotic? Such a suggestion is ridiculous. The same goes for the suggestion that minocycline induces autoimmuneA condition or disease thought to arise from an overactive immune response of the body against substances and tissues normally present in the body hepatitis. Show us the beef, please - the molecular mechanisms.

Remember that it was not too long ago that the majority of physicians agreed with the statement below. That consensus didn't make it any more correct…

In order to comprehend the discoveries springing from the cracking of the genome, today's physicians need to have a good understanding of modern science. It is tough for us to expect this, as many have not been even taught the basics of molecular biology. The alternative is for them to listen to those who are accepted as well grounded in science. Many physicians find that just as hard to swallow, as the profession trains them to present medicine, and its practitioners, to the public as infallible.

~Trevor

Side effects

Once you understand the immunopathologyA temporary increase in disease symptoms experienced by Marshall Protocol patients that results from the release of cytokines and endotoxins as disease-causing bacteria are killed. resulting from killing these Th1 pathogens, all these so-called side-effects are shown up for what they are - Immunopathology - and they disappear as you get rid of he pathogens.

..Trevor..

See also:

What should I know about Minocycline?

I'm allergic to an antibiotic on the Protocol. Is there a substitute?

Lupus In 'Overlap' With Other Connective Tissue Diseases

Antinuclear Antibody tests (ANA)

Bonnie B.

lupus, Sjogren’s Syndrome

Read the interview

Interviews of patients with other diseases are also available.