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The Marshall Protocol is a therapy for chronic inflammatory diseases created by Trevor Marshall, PhD. It is based on an explanation for how an infectious cascade of pathogens slow the immune response, allowing subsequent infections to proliferate, thereby causing the symptoms and markers of disease.

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For Patients

• Why microbes may cause chronic inflammatory diseases
  • Introduction to the Marshall Pathogenesis
  • Successive infection and variability in disease
  • Familial aggregation
  • Transmission of bacteria and onset of disease
  • Microbes in the human body
  • Evidence that chronic disease is caused by pathogens
• What is the Marshall Protocol? – The cornerstone of the MP is frequent dosing of olmesartan (brand name Benicar), which stimulates the innate immune response.
  • Introduction
  • Length – may take several years depending on how sick a patient is
  • Cost – insurance often pays for certain basic expenses; drugs can be ordered online at a discount
  • Palliative vs. curative treatments – many widely used treatments and supplements such as vitamin D compromise the immune response to microbes and are therefore contraindicated
• Considering the Marshall Protocol
  • Therapeutic probe – best method for determining suitability of the Protocol
  • Vitamin D Metabolite Calculator – get automated feedback on vitamin D blood tests
  • Patient interviews
• Starting the treatment – Overview | Checklist
• Physicians – Finding a physician | Working with a physician
• The Protocol – In-depth overview of the Protocol | Translations of this and other articles
  • Immunopathology – temporary increase in disease symptoms experienced by MP patients that is the result of microbial death; appears to be necessary for recovery
  • Managing immunopathology – certain strategies are helpful including lowering antibiotics and adjusting olmesartan
  • Light restriction – patients who are photosensitive on the MP become less symptomatic when they limit skin exposure to light when outdoors, and skin and eye exposure when indoors
  • Food & drink – patients limit vitamin D
  • Other treatments – patients only take other medications that offer needed relief from intolerable symptoms
• Learn more
  • Site map – contains a list of all articles in the KB
  • Publications and presentations
  • Glossary of terms

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For Physicians

• The Marshall Pathogenesis – an explanation for how microbes may cause chronic inflammatory diseases
  • Science behind Pathogenesis
  • Successive infection and variability in disease
  • Transmission of bacteria and onset of disease
  • Diseases – articles about microbes' role in a given chronic disease; note: many are works in progress
  • Evidence that chronic disease is caused by pathogens
  • Science behind vitamin D | Metabolism of vitamin D and the Vitamin D Receptor
• What is the Marshall Protocol? – The cornerstone of the MP is frequent dosing of olmesartan (brand name Benicar), which stimulates the innate immune response.
  • Marshall Protocol – one-page summary of the MP geared towards physicians
  • Physicians' concerns – olmesartan, antibiotics, light, vitamin D, immunopathology, clinical evidence
  • Olmesartan (Benicar) – Safety of olmesartan | Olmesartan and kidney disease
  • Antibiotics – Pulsed low-dose antibiotics | Safety
  • Therapeutic probe – best method for determining suitability of the Protocol
  • Immunopathology – also known as the Jarisch-Herxheimer reaction
  • Managing immunopathology – certain strategies are helpful including lowering antibiotics and adjusting olmesartan
  • Other treatments – patients only take other medications that offer needed relief from intolerable symptoms
  • Notice for emergency
• Alternative models for chronic disease
  • Autoimmune theory of disease
  • Genetic predisposition to disease
  • Psychosomatic explanations for disease
• Learn more
  • Resources for physicians
  • Publications and presentations
  • Diseases – articles about microbes' role in a given chronic disease; note: many are works in progress
  • Glossary of terms
  • Site map – contains a list of all articles in the KB

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