Vitamin D metabolite calculator

Recent research, including work done by the Autoimmunity Research FoundationNon-profit foundation dedicated to exploring a pathogenesis and therapy for chronic disease. research team, has shown that the Vitamin D nuclear receptorA nuclear receptor located throughout the body that plays a key role in the innate immune response. plays a key role in chronic and inflammatory disease. The VDRThe Vitamin D Receptor. A nuclear receptor located throughout the body that plays a key role in the innate immune response.'s transcription of genes is controlled in turn by the Vitamin D metabolism, which is progressively inhibited as the Th1 metagenomic microbiotaThe community of bacterial pathogens including those in an intracellular and biofilm state which cause chronic disease. gradually accumulates in the body's nucleated cells.

Below is an algorithm which will give physicians insight into how the most common Vitamin D metabolites can indicate disease status. This interpretation is not intended as any form of medical diagnosis; the physician must also take into account the general patient presentation and workup, and other objective measures of illness. This algorithm is based on research published in several papers and presentations.1) 2) 3) 4) 5)

1. Has the patient taken certain other drugs in the last 60 days including corticosteroids, other immunosuppressants (e.g. TNF-alpha drugs), or high-dose antibiotics.

2. Has the patient begun taking olmesartan (Benicar)?

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Marshall TG. Vitamin D discovery outpaces FDA decision making. Bioessays. 2008 Feb;30(2):173-82. doi: 10.1002/bies.20708.
[PMID: 18200565] [DOI: 10.1002/bies.20708]
Albert PJ, Proal AD, Marshall TG. Vitamin D: the alternative hypothesis. Autoimmun Rev. 2009 Jul;8(8):639-44. doi: 10.1016/j.autrev.2009.02.011. Epub 2009 Feb 12.
[PMID: 19393200] [DOI: 10.1016/j.autrev.2009.02.011]
Blaney G, et al. In press. Vitamin D Metabolites as Clinical Markers in Autoimmune and Chronic Disease. Annals of NY Academy of Sciences.
Perez T. MP Study Results. International Congress on Autoimmunity, Porto, 2008.
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