Recent research, including work done by the Autoimmunity Research FoundationNon-profit foundation dedicated to exploring a pathogenesis and therapy for chronic disease. research team, has shown that the Vitamin D nuclear receptorA nuclear receptor located throughout the body that plays a key role in the innate immune response. plays a key role in chronic and inflammatory disease. The VDRThe Vitamin D Receptor. A nuclear receptor located throughout the body that plays a key role in the innate immune response.'s transcription of genes is controlled in turn by the Vitamin D metabolism, which is progressively inhibited as the Th1 metagenomic microbiotaThe community of bacterial pathogens including those in an intracellular and biofilm state which cause chronic disease. gradually accumulates in the body's nucleated cells.
Below is an algorithm which will give physicians insight into how the most common Vitamin D metabolites can indicate disease status. This interpretation is not intended as any form of medical diagnosis; the physician must also take into account the general patient presentation and workup, and other objective measures of illness. This algorithm is based on research published in several papers and presentations.1) 2) 3) 4) 5)