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Paper - Immunostimulation in the era of the metagenome

Type: Paper
Authors: Amy D. Proal, Paul J. Albert, Greg P. Blaney M.D., Inge A. Lindseth, Chris Benediktsson and Trevor G Marshall PhD
Publication: Cellular & molecular immunology
Citation:

Immunostimulation in the era of the metagenome.
Proal AD, Albert PJ, Blaney GP, Lindseth IA, Benediktsson C, Marshall TG
Cell Mol Immunol8p213-25(2011 May)

See also: Preprint (full text)

Abstract

Microbes are increasingly being implicated in autoimmune disease. This calls for a re-evaluation of how these chronic inflammatory illnesses are routinely treated. The standard of care for autoimmune disease remains the use of medications that slow the immune response, while treatments aimed at eradicating microbes seek the exact opposite—stimulation of the innate immune response. Immunostimulation is complicated by a cascade of sequelae, including exacerbated inflammation, which occurs in response to microbial death. Over the past 8 years, we have collaborated with American and international clinical professionals to research a model-based treatment for inflammatory disease. This intervention, designed to stimulate the innate immune response, has required a reevaluation of disease progression and amelioration. Paramount is the inherent conflict between palliation and microbicidal efficacy. Increased microbicidal activity was experienced as immunopathology—a temporary worsening of symptoms. Further studies are needed, but they will require careful planning to manage this immunopathology.

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