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home:alternate:genetic_predisposition [08.27.2012] – [Pathogens may cause genetic mutations] paulalberthome:alternate:genetic_predisposition [07.19.2015] – [Schizophrenia] sallieq
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 ==== Schizophrenia ==== ==== Schizophrenia ====
  
-In 2009, a press conference at the World Conference of Science Journalists, [[http://tierneylab.blogs.nytimes.com/2009/07/01/hoopla-and-disappointment-in-schizophrenia-research/?hpw|triumphanantly unveiled]] three large studies of the genetics of schizophrenia.(({{pubmed>long:19571808}})) Press releases from five American and European institutions celebrated the findings, one using epithets like “landmark,” “major step forward,” and “real scientific breakthrough.” The media coverage for these papers was likewise triumphal, talking about breakthroughs and a discovery that could lead to new treatments for millions with the illnesses. One exception was a [[http://www.reuters.com/article/healthNews/idUSTRE5605PO20090701|Reuters article]] that said, “as many as 30,000 different gene variations may underlie schizophrenia and bipolar disease, meaning any kind of quick test to predict either disease is a long way off.” +In 2009, a press conference at the World Conference of Science Journalists, [[http://tierneylab.blogs.nytimes.com/2009/07/01/hoopla-and-disappointment-in-schizophrenia-research/?hpw|triumphantly unveiled]] three large studies of the genetics of schizophrenia.(({{pubmed>long:19571808}})) Press releases from five American and European institutions celebrated the findings, one using epithets like “landmark,” “major step forward,” and “real scientific breakthrough.” The media coverage for these papers was likewise triumphal, talking about breakthroughs and a discovery that could lead to new treatments for millions with the illnesses. One exception was a [[http://www.reuters.com/article/healthNews/idUSTRE5605PO20090701|Reuters article]] that said, “as many as 30,000 different gene variations may underlie schizophrenia and bipolar disease, meaning any kind of quick test to predict either disease is a long way off.” 
  
 <blockquote>It was the kind of hoopla you’d expect for an actual scientific advance. It seems to me the reports represent more of a historic defeat, a Pearl Harbor of schizophrenia research.... <blockquote>It was the kind of hoopla you’d expect for an actual scientific advance. It seems to me the reports represent more of a historic defeat, a Pearl Harbor of schizophrenia research....
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 ===== Bacteria are "inherited" between generations ===== ===== Bacteria are "inherited" between generations =====
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 +<blockquote>There’s a 0.1% difference in our genomes, but there may be a 50% difference in our metagenome. If the variability is higher, you’re more likely to find a relevant signal.... It’s hard to be a prophet, but we see so much more potential in the human-other-genome than in our own genome.
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 +//**Dusko Ehrlich**, [[http://www.nature.com/news/microbiome-sequencing-offers-hope-for-diagnostics-1.10299|Project Coordinator for MetaHIT]]//</blockquote>
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 Strong evidence indicates that pathogens play the primary role in chronic disease. Scientists have confirmed that bacteria are [[home:pathogenesis:transmission|transmitted]] through a series of vectors including:  Strong evidence indicates that pathogens play the primary role in chronic disease. Scientists have confirmed that bacteria are [[home:pathogenesis:transmission|transmitted]] through a series of vectors including: 
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 While there is no evidence that human genes contain instructions for chronic disease, there is reason to believe that a body's unique pathogenic load, its [[home:pathogenesis:successive_infection#pea_soup|pea soup]], causes mutations in human DNA. Pea soup refers to the diverse and ever-changing human microbiota, a broad array of bacteria comprised of various forms and at least hundreds of species. Many of these bacteria were thought only recently never to exist in man. A 2007 study, for example, found [[http://www.divediscover.whoi.edu/hottopics/bacteria.html|hydrothermal vent eubacteria]] on a prosthetic hip joint.(({{pubmed>long:17501992}})) While there is no evidence that human genes contain instructions for chronic disease, there is reason to believe that a body's unique pathogenic load, its [[home:pathogenesis:successive_infection#pea_soup|pea soup]], causes mutations in human DNA. Pea soup refers to the diverse and ever-changing human microbiota, a broad array of bacteria comprised of various forms and at least hundreds of species. Many of these bacteria were thought only recently never to exist in man. A 2007 study, for example, found [[http://www.divediscover.whoi.edu/hottopics/bacteria.html|hydrothermal vent eubacteria]] on a prosthetic hip joint.(({{pubmed>long:17501992}}))
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 ===== Pathogens may cause genetic mutations ===== ===== Pathogens may cause genetic mutations =====
  
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   * [[http://www.wired.com/wiredscience/2009/10/beyond-the-genome/|Beyond the Genome]] – 2009 Wired article that describes how when scientists finished sequencing the human genome, the answers to diseases were supposed to follow. Six years later, that promise has gone unfulfilled.    * [[http://www.wired.com/wiredscience/2009/10/beyond-the-genome/|Beyond the Genome]] – 2009 Wired article that describes how when scientists finished sequencing the human genome, the answers to diseases were supposed to follow. Six years later, that promise has gone unfulfilled. 
   * [[http://tierneylab.blogs.nytimes.com/2009/07/01/hoopla-and-disappointment-in-schizophrenia-research/?hpw|Hoopla, and Disappointment, in Schizophrenia Research]] – 2009 New York Times article on the failure of genomic association studies in schizophrenia research   * [[http://tierneylab.blogs.nytimes.com/2009/07/01/hoopla-and-disappointment-in-schizophrenia-research/?hpw|Hoopla, and Disappointment, in Schizophrenia Research]] – 2009 New York Times article on the failure of genomic association studies in schizophrenia research
 +  * [[http://www.nytimes.com/2012/04/03/health/research/dnas-power-to-predict-is-limited-study-finds.html?_r=1|Study Says DNA’s Power to Predict Illness Is Limited]]
  
 {{tag>Th1_disease genetics human_microbiome}} {{tag>Th1_disease genetics human_microbiome}}
    
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 ===== Notes and comments ===== ===== Notes and comments =====
  
home/alternate/genetic_predisposition.txt · Last modified: 09.14.2022 by 127.0.0.1
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