Chiller K, Selkin BA, Murakawa GJ
J Investig Dermatol Symp Proc6p170-4(2001 Dec)
Related article: Skin conditions
Psoriasis is an autoimmune disease that affects the skin that varies in severity from minor localized patches to complete body coverage. The richness of the skin microbiome and the emerging discrepancies between the microbial composition between health and disease point to a microbial etiology for psoriasis.
The Marshall Protocol treats psoriasis by reactivating the innate immune response. In the course of treatment, patients' disease symptoms may become worse due to a process called immunopathology.
A decade ago, Chiller et al. concluded, “The skin is a poor media for bacteria given the large number of inherent defense mechanisms.”1) This assessment was undermined seven years later by Fierer et al.’s work, which found that the average human palm harbors at least 150 bacterial species – an order of magnitude greater than previous estimates.2) A 2009 Science study expanded on this understanding of microbial diversity in skin, showing that forearms and underarms, though located just a short distance apart, are as “ecologically dissimilar as rainforests are to deserts.”3) Trillions of bacteria, fungi, viruses, archaea, and small arthropods colonize the skin surface, collectively comprising the skin microbiome.4) One prominent researcher called human skin a “virtual zoo of bacteria.”5)
Novel insights are being revealed about the extent to which skin microbiota affects health. For example, odors produced by skin microbiota are attractive to mosquitoes as shown by in vitro studies, and variation in bacterial species on the human skin may explain the variation in mosquito attraction between humans.6)
For many physicians, immunosuppressive medications are a first-line treatment for psoriasis. These drugs suppress the innate immune response, which provides some patients with temporary symptom palliation, because they reduce immunopathology, the bacterial die-off reaction.
I've had lots of experience with psoriasis (which looks like sarc lesions, BTW). I've found a cream that helps it feel better. It's a combo of mango and shea butter that I buy at Walmart, made by Tree Hut. It's very soothing.
Interviews of patients with other diseases are also available.