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home:alternate:genetic_predisposition [07.19.2015] – [Schizophrenia] sallieqhome:alternate:genetic_predisposition [07.20.2015] – [Notes and comments] sallieq
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 Many researchers have long argued that most chronic diseases are caused by humans' genetic predisposition for a condition. However, despite ambitious efforts, there is substantial evidence that chronic diseases are not caused by human genes. Studies of monozygotic (fraternal) twins are particularly damning. The high percentage of disease-discordant pairs of monozygotic twins demonstrates the central role of environmental factors (like microbes) in the cause of autoimmune diseases, to say nothing of similar data about other inflammatory diseases such as cancer.(({{pubmed>long:16278064}})) Many researchers have long argued that most chronic diseases are caused by humans' genetic predisposition for a condition. However, despite ambitious efforts, there is substantial evidence that chronic diseases are not caused by human genes. Studies of monozygotic (fraternal) twins are particularly damning. The high percentage of disease-discordant pairs of monozygotic twins demonstrates the central role of environmental factors (like microbes) in the cause of autoimmune diseases, to say nothing of similar data about other inflammatory diseases such as cancer.(({{pubmed>long:16278064}}))
  
-According to the [[home::pathogenesis|Marshall Pathogenesis]], humans accumulate a plethora of pathogenic bacteria during their lifetimes, and it is the genetic mutations and disruption of key transciptional pathways which result from active infection that play a major role in what is commonly thought of as “genetic susceptibility.”+According to the [[home::pathogenesis|Marshall Pathogenesis]], humans accumulate a plethora of pathogenic bacteria during their lifetimes, and it is the genetic mutations and disruption of key transcriptional pathways which result from active infection that play a major role in what is commonly thought of as “genetic susceptibility.”
  
 <blockquote>If anything, we don't really know how to read the genome and it can't tell us very much right now. So what's the ethical debate about?... We couldn't even be certain from my genome what my eye color was. Isn't that sad? Everyone was looking for miracle 'yes/no' answers in the genome. "Yes, you'll have cancer." Or "No, you won't have cancer." But that's just not the way it is.... [The Human Genome Project has had] close to zero [medical benefit] to put it precisely....  We have, in truth, learned nothing from the genome other than probabilities. How does a 1 or 3 percent increased risk for something translate into the clinic? It is useless information. <blockquote>If anything, we don't really know how to read the genome and it can't tell us very much right now. So what's the ethical debate about?... We couldn't even be certain from my genome what my eye color was. Isn't that sad? Everyone was looking for miracle 'yes/no' answers in the genome. "Yes, you'll have cancer." Or "No, you won't have cancer." But that's just not the way it is.... [The Human Genome Project has had] close to zero [medical benefit] to put it precisely....  We have, in truth, learned nothing from the genome other than probabilities. How does a 1 or 3 percent increased risk for something translate into the clinic? It is useless information.
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 ===== Notes and comments ===== ===== Notes and comments =====
  
 +&#genetic_predisposition_to_disease
 +//inserted// r in “ key transc**r**iptional pathways”
 +further down @ &#Schizophrenia
 +//deleted repetition of// an from triumph**an**antly    –Sallie Q July'15 
  
  
home/alternate/genetic_predisposition.txt · Last modified: 09.14.2022 by 127.0.0.1
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