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home:arf:timeline [02.14.2019]
sallieq [Notes and comments]
home:arf:timeline [02.14.2019]
sallieq [Timeline of the Marshall Protocol Discoveries]
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 **1999** – Marshall learns that other patients with sarcoidosis who were administered Angiotensin Receptor Blockers (ARBs) often developed a neurological reaction. Marshall starts a sabbatical in early 2001 in order to further investigate this reaction. **1999** – Marshall learns that other patients with sarcoidosis who were administered Angiotensin Receptor Blockers (ARBs) often developed a neurological reaction. Marshall starts a sabbatical in early 2001 in order to further investigate this reaction.
  
-**2001** - Marshall submits paper explaining that sarcoidosis could have a bacterial pathogenesis. Three revisions of the paper are rejected by the journal ​"Sarcoidosis,​ Vasculitis and Diffuse Lung Diseases" ​ as having no potential interest for its readers. ​+**2001** - Marshall submits paper explaining that sarcoidosis could have a bacterial pathogenesis. Three revisions of the paper are rejected by the journal ​//Sarcoidosis,​ Vasculitis and Diffuse Lung Diseases//  as having no potential interest for its readers. ​
  
 **2001 March** - The first early adopter, Elaine Emmi, begins the use of an ARB to treat her sarcoidosis. **2001 March** - The first early adopter, Elaine Emmi, begins the use of an ARB to treat her sarcoidosis.
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 **2001 December** - Nilsson //et al.// publish article in //Journal of infectious disease// showing that deceased sarcoidosis patients contain the genetic material from //​Rickettsia helvetica// in the cytoplasm of cells within sarcoid granuloma.(({{pubmed>​long:​11930323}})) Marshall commences using pulsed, sub-inhibitory,​ doses of antibiotics in an attempt to reverse his sarcoidosis. **2001 December** - Nilsson //et al.// publish article in //Journal of infectious disease// showing that deceased sarcoidosis patients contain the genetic material from //​Rickettsia helvetica// in the cytoplasm of cells within sarcoid granuloma.(({{pubmed>​long:​11930323}})) Marshall commences using pulsed, sub-inhibitory,​ doses of antibiotics in an attempt to reverse his sarcoidosis.
  
-**2002 March** –  Marshall registers ​[[http://sarcinfo.com|Sarcinfo.com]], a forum-based website where patients sick with sarcoidosis begin to discuss a novel antibacterial therapy for the disease.+**2002 March** –  Marshall registers ​"//​Sarcinfo.com//", a forum-based website where patients sick with sarcoidosis begin to discuss a novel antibacterial therapy for the disease.
  
 **2002 May** –  Marshall changes to using the ARB olmesartan medoxomil (Benicar). ​ **2002 May** –  Marshall changes to using the ARB olmesartan medoxomil (Benicar). ​
  
-**2002 August** – Trevor Marshall and Frances (Liz) Marshall publish NetPrint, "[[http://clinmed.netprints.org/​cgi/​content/​full/​2002080006|Valsartan Dosing Regime Modulates Psychotic Events in Two Sarcoidosis Patients]]." ​The case report shares early observations that valsartan (Diovan) induced hallucinations and psychedelic dreams. Convinced that they have developed a pathogenic description of sarcoidosis,​ they write the Netprint "[[http://clinmed.netprints.org/​cgi/​content/​full/​2002080004|Remission in Sarcoidosis]]"+**2002 August** – Trevor Marshall and Frances (Liz) Marshall publish NetPrint, "//​Valsartan Dosing Regime Modulates Psychotic Events in Two Sarcoidosis Patients//". The case report shares early observations that valsartan (Diovan) induced hallucinations and psychedelic dreams. Convinced that they have developed a pathogenic description of sarcoidosis,​ they write the Netprint "//​Remission in Sarcoidosis//"
  
-**2002 September** – "​[[http:​//clinmed.netprints.org/​cgi/​content/​full/​2002080004|Remission in Sarcoidosis]]" ​is published (in summary) at Mercola.com. Later that month, early adopter (and colleague) Belinda Fenter commences pulsed minocycline.+**2002 September** –  //Remission in Sarcoidosis// is published (in summary) at Mercola.com. Later that month, early adopter (and colleague) Belinda Fenter commences pulsed minocycline.
  
 **2002 December** – Early adopter (and colleague) Meg Mangin commences pulsed tetracycline. ​ **2002 December** – Early adopter (and colleague) Meg Mangin commences pulsed tetracycline. ​
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  ​Seperately,​ images from Emil Wirostko'​s group(({{pubmed>​long:​15043554}})) (({{pubmed>​long:​8622416}})) (({{pubmed>​long:​7892050}})) finally confirmed that a cytoplasmic microbiota of intraphagocytic,​ L-form bacteria must drive the biochemical changes observed in sarcoidosis.  ​Seperately,​ images from Emil Wirostko'​s group(({{pubmed>​long:​15043554}})) (({{pubmed>​long:​8622416}})) (({{pubmed>​long:​7892050}})) finally confirmed that a cytoplasmic microbiota of intraphagocytic,​ L-form bacteria must drive the biochemical changes observed in sarcoidosis.
  
-**2003 January** – Mangin changes to minocycline and commences concurrent olmesartan. Fenter also commences using olmesartan. They are joined by Ms. Dale Thurlow, and Marshall'​s Protocol has taken root. Later that month Trevor Marshall and Frances (Liz) Marshall publish "[[http://​clinmed.netprints.org/​cgi/​content/​full/​2003010001|New Treatments Emerge as Sarcoidosis Yields Up its Secrets]]" on Clinmed, after it is savaged by two pulmonologist peer-reviewers for "BMC Pulmonary Medicine"​+**2003 January** – Mangin changes to minocycline and commences concurrent olmesartan. Fenter also commences using olmesartan. They are joined by Ms. Dale Thurlow, and Marshall'​s Protocol has taken root. Later that month Trevor Marshall and Frances (Liz) Marshall publish "New Treatments Emerge as Sarcoidosis Yields Up its Secrets"​ on Clinmed, after it is savaged by two pulmonologist peer-reviewers for "BMC Pulmonary Medicine"​
  
 **2004 April** – Autoimmunity Research Foundation is founded. **2004 April** – Autoimmunity Research Foundation is founded.
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 **2004 July** – Marshall registers [[http://​marshallprotocol.com|MarshallProtocol.com]],​ a website where patients sick with a range of chronic diseases discuss an antibacterial therapy since named the "​Marshall Protocol."​ – Aussie Barb joins MarshallProtocol.com and begins to perform an invaluable behind-the-scenes role on the study site. **2004 July** – Marshall registers [[http://​marshallprotocol.com|MarshallProtocol.com]],​ a website where patients sick with a range of chronic diseases discuss an antibacterial therapy since named the "​Marshall Protocol."​ – Aussie Barb joins MarshallProtocol.com and begins to perform an invaluable behind-the-scenes role on the study site.
  
-**2004 December** - The Journal of the Interregional Clinical-Diagnostic Center, Kazan, Russia, (ISSN: 1726-6149) publishes, in Russian translation,​ Marshall'​s paper "[[http://www.joimr.org/​phorum/​read.php?​f=2&​i=107&​t=107|Antibacterial Therapy Induces Remission in Sarcoidosis]]" in its special issue on Sarcoidosis. ​+**2004 December** - [[http://​www.joimr.org/​|joimr]] ​The Journal of the Interregional Clinical-Diagnostic Center, Kazan, Russia, (ISSN: 1726-6149) publishes, in Russian translation,​ Marshall'​s paper "//​Antibacterial Therapy Induces Remission in Sarcoidosis//" in its special issue on Sarcoidosis. ​
  
 **2005 March ** – ARF's '​Recovering from Chronic Disease'​ conference held in Chicago. Notable speakers include Lida Mattman PhD and Dr. Andrew Wright. **2005 March ** – ARF's '​Recovering from Chronic Disease'​ conference held in Chicago. Notable speakers include Lida Mattman PhD and Dr. Andrew Wright.
  
-**2005 June** - Marshall publishes the English text of the Russian paper "​[[http://​www.joimr.org/​phorum/​read.php?​f=2&​i=107&​t=107|Antibacterial Therapy Induces Remission in Sarcoidosis]]"+**2005 June** - Marshall publishes the English text of the Russian paper "//​Antibacterial Therapy Induces Remission in Sarcoidosis//​" [[http://​www.joimr.org/​|joimr]]
  
 **2005 July** – Marshall files for [[http://​www.freepatentsonline.com/​y2006/​0025358.html|patent]] with US Patent and Trademark Office (eventually published in February 2006) which explains a method of killing the stealthy intracellular bacteria which cause many Th1 and "​autoimmune"​ diseases. A [[http://​www.freepatentsonline.com/​y2007/​0135504.html|second patent]] which specifies a broader range of chronic diseases is filed in December 2006. **2005 July** – Marshall files for [[http://​www.freepatentsonline.com/​y2006/​0025358.html|patent]] with US Patent and Trademark Office (eventually published in February 2006) which explains a method of killing the stealthy intracellular bacteria which cause many Th1 and "​autoimmune"​ diseases. A [[http://​www.freepatentsonline.com/​y2007/​0135504.html|second patent]] which specifies a broader range of chronic diseases is filed in December 2006.
home/arf/timeline.txt · Last modified: 02.14.2019 by sallieq
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