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home:diseases:aging [08.26.2017] – [Diet] sallieq | home:diseases:aging [01.26.2019] – [Breaking up defunct cells] sallieq | ||
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====== Aging (senescence) ====== | ====== Aging (senescence) ====== | ||
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The biological basis of aging (also known as senescence) is the subject of debate. A number of theories suggest aging is inevitable, the product of "wear and tear" or a result of some evolutionary necessity. For example, Skulachev argues that aging performs a specific biological function, with the turnover in new members of a species promoting greater evolutionary fitness.(({{pubmed> | The biological basis of aging (also known as senescence) is the subject of debate. A number of theories suggest aging is inevitable, the product of "wear and tear" or a result of some evolutionary necessity. For example, Skulachev argues that aging performs a specific biological function, with the turnover in new members of a species promoting greater evolutionary fitness.(({{pubmed> | ||
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* **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | * **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | ||
+ | ==== Breaking up defunct cells ==== | ||
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+ | Senolytics in idiopathic pulmonary fibrosis]] | ||
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+ | Our first-in-humans open-label pilot supports study feasibility and provides initial evidence that senolytics may alleviate physical dysfunction in IPF (({{pubmed> | ||
===== Diseases of the aging are chronic diseases ===== | ===== Diseases of the aging are chronic diseases ===== | ||
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Aging deeply affects (or is affected by!) the human microbiota' | Aging deeply affects (or is affected by!) the human microbiota' | ||
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* **autoimmune** – As people age, their risk for developing an " | * **autoimmune** – As people age, their risk for developing an " | ||
+ | * **macrophage function** – Macrophages, | ||
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Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | ||
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//**E. Cevenini**// | //**E. Cevenini**// | ||
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* **Vitamin D restriction reduces signs of aging in certain mice** – The Klotho-insufficient (klotho) mouse exhibits a syndrome that resembles human aging including retarded growth, osteoporosis, | * **Vitamin D restriction reduces signs of aging in certain mice** – The Klotho-insufficient (klotho) mouse exhibits a syndrome that resembles human aging including retarded growth, osteoporosis, | ||
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+ | ===== Falls and Fractures ===== | ||
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+ | The major change is the downgrade of the vitamin D supplementation recommendation for preventing falls from being a B grade (recommended based on high certainty of moderate benefit or on moderate certainty of moderate to substantial benefit) to a D grade (recommended against based on moderate or high certainty of no benefit or that harms outweigh the benefit). For falls prevention, exercise remains a B grade recommendation, | ||
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===== Read more ===== | ===== Read more ===== | ||
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* **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | * **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | ||
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+ | ==== summary of Olmesartan research on aging ==== | ||
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+ | [[home: | ||
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{{tag> | {{tag> | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | minor edit --- //Sallie Q 08.13.2017// edited 27 July | + | //Lee// " I am 70 now (not 65) when we started this conversation ...lolDr' |
< | < |