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home:diseases:aging [10.19.2018] – [Notes and comments] sallieq | home:diseases:aging [01.26.2019] – [Conventional explanations for aging] sallieq | ||
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====== Aging (senescence) ====== | ====== Aging (senescence) ====== | ||
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The biological basis of aging (also known as senescence) is the subject of debate. A number of theories suggest aging is inevitable, the product of "wear and tear" or a result of some evolutionary necessity. For example, Skulachev argues that aging performs a specific biological function, with the turnover in new members of a species promoting greater evolutionary fitness.(({{pubmed> | The biological basis of aging (also known as senescence) is the subject of debate. A number of theories suggest aging is inevitable, the product of "wear and tear" or a result of some evolutionary necessity. For example, Skulachev argues that aging performs a specific biological function, with the turnover in new members of a species promoting greater evolutionary fitness.(({{pubmed> | ||
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* **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | * **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | ||
+ | ==== defunct cells ==== | ||
+ | [[https:// | ||
+ | Senolytics in idiopathic pulmonary fibrosis]] | ||
===== Diseases of the aging are chronic diseases ===== | ===== Diseases of the aging are chronic diseases ===== | ||
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Aging deeply affects (or is affected by!) the human microbiota' | Aging deeply affects (or is affected by!) the human microbiota' | ||
- | * **macrophage function** – Macrophages, | + | |
* **autoimmune** – As people age, their risk for developing an " | * **autoimmune** – As people age, their risk for developing an " | ||
+ | * **macrophage function** – Macrophages, | ||
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Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | ||
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//**E. Cevenini**// | //**E. Cevenini**// | ||
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===== Read more ===== | ===== Read more ===== | ||
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* **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | * **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | ||
+ | * [[https:// | ||
+ | ==== summary of Olmesartan research on aging ==== | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | //Lee// " I am 70 now (not 65) when we started this conversation ...lolDr' | ||
< | < |