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home:diseases:aging [10.19.2018] – [Notes and comments] sallieq | home:diseases:aging [08.12.2019] – [Infections may drive age-related memory loss] sallieq | ||
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====== Aging (senescence) ====== | ====== Aging (senescence) ====== | ||
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The biological basis of aging (also known as senescence) is the subject of debate. A number of theories suggest aging is inevitable, the product of "wear and tear" or a result of some evolutionary necessity. For example, Skulachev argues that aging performs a specific biological function, with the turnover in new members of a species promoting greater evolutionary fitness.(({{pubmed> | The biological basis of aging (also known as senescence) is the subject of debate. A number of theories suggest aging is inevitable, the product of "wear and tear" or a result of some evolutionary necessity. For example, Skulachev argues that aging performs a specific biological function, with the turnover in new members of a species promoting greater evolutionary fitness.(({{pubmed> | ||
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+ | Inflammation, | ||
Health of the hypothalamus may be a controlling factor as demonstrated in a mouse study by Yalin Zhang et al < | Health of the hypothalamus may be a controlling factor as demonstrated in a mouse study by Yalin Zhang et al < | ||
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* **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | * **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | ||
+ | ==== Breaking up defunct cells ==== | ||
+ | [[https:// | ||
+ | Senolytics in idiopathic pulmonary fibrosis]] | ||
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+ | Our first-in-humans open-label pilot supports study feasibility and provides initial evidence that senolytics may alleviate physical dysfunction in IPF (({{pubmed> | ||
===== Diseases of the aging are chronic diseases ===== | ===== Diseases of the aging are chronic diseases ===== | ||
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Aging deeply affects (or is affected by!) the human microbiota' | Aging deeply affects (or is affected by!) the human microbiota' | ||
- | * **macrophage function** – Macrophages, | + | |
* **autoimmune** – As people age, their risk for developing an " | * **autoimmune** – As people age, their risk for developing an " | ||
+ | * **macrophage function** – Macrophages, | ||
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Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | ||
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//**E. Cevenini**// | //**E. Cevenini**// | ||
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{{section>: | {{section>: | ||
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+ | ==== Research into effects of Olmesartan ==== | ||
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===== Role of vitamin D metabolism ===== | ===== Role of vitamin D metabolism ===== | ||
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+ | ===== Recent research ===== | ||
+ | Cell membranes are primarily made up of two types of lipids — phospholipids and glycolipids. Inside cells, these lipids bind to a molecule called CD1d that transports them to the surface. Once there, phospholipids stimulate phospholipid-reactive T cells, and glycolipids stimulate a different type of T cell called iNKTs. | ||
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+ | On their way to the cell’s surface, phospholipids more easily attach themselves to CD1d molecules, making it more difficult for glycolipids to attach to CD1d. Because of this, it is harder for glycolipids to make it to the surface of the cell. This means that iNKTs cannot be as easily stimulated by glycolipids. | ||
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+ | Scientists believe iNKT cells are necessary because they appear to protect cells against the progression of certain cancers and autoimmune diseases. However, iNKT cells are extremely active and can cause alcoholic hepatitis or other types of liver diseases if they are overstimulated. The phospholipid’s ability to more easily bind to CD1d molecules than glycolipids keeps a balance between the two cell types and maintains homeostasis in the immune system. | ||
===== Read more ===== | ===== Read more ===== | ||
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* **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | * **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | ||
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+ | ==== summary of research into effects of Olmesartan ==== | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | //Lee// " I am 70 now (not 65) when we started this conversation ...lolDr' | ||
+ | (({{pubmed> | ||
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< | < | ||