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home:diseases:aging [11.28.2018] – [Examples of some of the documented protective effects of ARBs] sallieq | home:diseases:aging [09.14.2022] (current) – external edit 127.0.0.1 | ||
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====== Aging (senescence) ====== | ====== Aging (senescence) ====== | ||
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- | The biological basis of aging (also known as senescence) is the subject of debate. A number of theories suggest aging is inevitable, the product of "wear and tear" or a result of some evolutionary necessity. For example, Skulachev argues that aging performs a specific biological function, with the turnover in new members of a species promoting greater evolutionary fitness.(({{pubmed> | + | The biological basis of aging (also known as senescence) is the subject of debate. A number of theories suggest aging is inevitable, the product of "wear and tear" or a result of some evolutionary necessity. For example, Skulachev argues that aging performs a specific biological function, with the turnover in new members of a species promoting greater evolutionary fitness.(({{pmid> |
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- | Health of the hypothalamus may be a controlling factor as demonstrated in a mouse study by Yalin Zhang et al < | + | Inflammation, |
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+ | Health of the hypothalamus may be a controlling factor as demonstrated in a mouse study by Yalin Zhang et al < | ||
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* **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | * **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | ||
+ | ==== Breaking up defunct cells ==== | ||
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+ | [[https:// | ||
+ | Senolytics in idiopathic pulmonary fibrosis]] | ||
+ | < | ||
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+ | Our first-in-humans open-label pilot supports study feasibility and provides initial evidence that senolytics may alleviate physical dysfunction in IPF (({{pmid> | ||
===== Diseases of the aging are chronic diseases ===== | ===== Diseases of the aging are chronic diseases ===== | ||
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< | < | ||
- | //**Paul Ewald**, [[http:// | + | //**Paul Ewald**, [[https:// |
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===== Infection and decline in immune function ===== | ===== Infection and decline in immune function ===== | ||
- | A typical feature of aging is a chronic, low-grade inflammation characterized by a general increase in the production of pro-inflammatory cytokines and inflammatory markers.(({{pubmed> | + | A typical feature of aging is a chronic, low-grade inflammation characterized by a general increase in the production of pro-inflammatory cytokines and inflammatory markers.(({{pmid> |
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+ | Aging deeply affects (or is affected by!) the human microbiota' | ||
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+ | * **autoimmune** – As people age, their risk for developing an " | ||
+ | * **macrophage function** – Macrophages, | ||
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+ | < | ||
- | Aging deeply affects (or is affected by!) the human microbiota' | ||
- | * **macrophage function** – Macrophages, | ||
- | * **autoimmune** – As people age, their risk for developing an " | ||
Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | ||
- | < | + | < |
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+ | //**E. Cevenini**// | ||
- | //**E. Cevenini**// | ||
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{{section>: | {{section>: | ||
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+ | ===== Research into effects of Olmesartan ===== | ||
+ | [[home: | ||
===== Role of vitamin D metabolism ===== | ===== Role of vitamin D metabolism ===== | ||
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< | < | ||
- | //**T. Keisala** et al.//(({{pubmed> | + | //**T. Keisala** et al.//(({{pmid> |
- | * **Vitamin D restriction reduces signs of aging in certain mice** – The Klotho-insufficient (klotho) mouse exhibits a syndrome that resembles human aging including retarded growth, osteoporosis, | + | * **Vitamin D restriction reduces signs of aging in certain mice** – The Klotho-insufficient (klotho) mouse exhibits a syndrome that resembles human aging including retarded growth, osteoporosis, |
===== Falls and Fractures ===== | ===== Falls and Fractures ===== | ||
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+ | ===== Recent research ===== | ||
- | ===== Read more ===== | + | Cell membranes are primarily made up of two types of lipids — phospholipids and glycolipids. Inside cells, these lipids bind to a molecule called CD1d that transports them to the surface. Once there, phospholipids stimulate phospholipid-reactive T cells, and glycolipids stimulate a different type of T cell called iNKTs. |
- | * **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | + | On their way to the cell’s surface, phospholipids more easily attach themselves to CD1d molecules, making it more difficult for glycolipids to attach to CD1d. Because |
+ | Scientists believe iNKT cells are necessary because they appear to protect cells against the progression of certain cancers and autoimmune diseases. However, iNKT cells are extremely active and can cause alcoholic hepatitis or other types of liver diseases if they are overstimulated. The phospholipid’s ability to more easily bind to CD1d molecules than glycolipids keeps a balance between the two cell types and maintains homeostasis in the immune system. | ||
+ | ===== Read more ===== | ||
- | ==== summary | + | * **Declining testosterone levels in men not part of normal |
+ | * [[https:// | ||
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- | [[home: | ||
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{{tag> | {{tag> | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | //Lee// " I am 70 now (not 65) when we started this conversation ...lolDr' | ||
+ | (({{pmid> | ||
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< | < | ||
- | * [[http:// | + | * [[https:// |
- | * [[http:// | + | * [[https:// |
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< | < | ||
- | There is a branch of medicine which is starting to look at Immunity and Aging. Here is a short letter I recently wrote to the editor of one of the journals: [[http:// | + | There is a branch of medicine which is starting to look at Immunity and Aging. Here is a short letter I recently wrote to the editor of one of the journals: [[https:// |
//**Trevor Marshall, PhD**// </ | //**Trevor Marshall, PhD**// </ | ||
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{{ : | {{ : | ||
- | Cawthorn et al examined the [[http:// | + | Cawthorn et al examined the [[https:// |
A number of the sickest patients on the Marshall Protocol, who are killing intracellular bacteria at the fastest rate possible, take over three years to completely recover their health. This hints at the large amount of pathogen-altered DNA that many people, even those who are not yet displaying the hallmarks of Th1 disease, are carrying. | A number of the sickest patients on the Marshall Protocol, who are killing intracellular bacteria at the fastest rate possible, take over three years to completely recover their health. This hints at the large amount of pathogen-altered DNA that many people, even those who are not yet displaying the hallmarks of Th1 disease, are carrying. | ||
- | Study shows that most older adults have signs of brain damage [[http:// | + | Study shows that most older adults have signs of brain damage [[https:// |
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People who haven’t completed the MP consider it inevitable that as they age, they will need to stock up on any number of medications including thyroid medications, | People who haven’t completed the MP consider it inevitable that as they age, they will need to stock up on any number of medications including thyroid medications, | ||
- | //**Amy Proal**, [[http:// | + | //**Amy Proal**, [[https:// |
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- | < | + | < |
Authors: Eyal Talora; Noel R. Rosea | Authors: Eyal Talora; Noel R. Rosea | ||
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the cells is good, bad or indifferent. | the cells is good, bad or indifferent. | ||
- | http:// | + | https:// |
</ | </ | ||
- | ===== References ===== | + | ===== References =====</ |