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home:diseases:aging [12.06.2018] – [Aging (senescence)] sallieq | home:diseases:aging [01.26.2019] – [defunct cells] sallieq | ||
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* **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | * **Cellular theory** – According to this theory, the normal body has a finite potential to replicate and maintain functional capacity (Hayflick limit). | ||
+ | ==== Breaking up defunct cells ==== | ||
+ | [[https:// | ||
+ | Senolytics in idiopathic pulmonary fibrosis]] | ||
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+ | Our first-in-humans open-label pilot supports study feasibility and provides initial evidence that senolytics may alleviate physical dysfunction in IPF (({{pubmed> | ||
===== Diseases of the aging are chronic diseases ===== | ===== Diseases of the aging are chronic diseases ===== | ||
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Aging deeply affects (or is affected by!) the human microbiota' | Aging deeply affects (or is affected by!) the human microbiota' | ||
- | * **macrophage function** – Macrophages, | + | |
* **autoimmune** – As people age, their risk for developing an " | * **autoimmune** – As people age, their risk for developing an " | ||
+ | * **macrophage function** – Macrophages, | ||
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Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. | ||
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//**E. Cevenini**// | //**E. Cevenini**// | ||
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* **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | * **Declining testosterone levels in men not part of normal aging, study finds** – A [[http:// | ||
+ | * [[https:// | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | //Lee// " I am 70 now (not 65) when we started this conversation ...lolDr' | ||
< | < |