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====== Baldness (alopecia) ====== | ====== Baldness (alopecia) ====== | ||
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+ | ===== Introduction ===== | ||
__In search of the "hair cycle clock": | __In search of the "hair cycle clock": | ||
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Here, we sketch basic background information and key concepts that one needs to keep in mind when exploring the enigmatic "hair cycle clock" | Here, we sketch basic background information and key concepts that one needs to keep in mind when exploring the enigmatic "hair cycle clock" | ||
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Maryborough, | Maryborough, | ||
- | Additional data was collected on dandruff, presence of gray hair. Supplementary questionnaires were sent to 340 children aged 5-9, attending a coeducational primary school. 1456 adults (34.1%) responded to the questionnaire. 396 attended for examination. The prevalence of androgenetic alopecia (AGA) increased with advancing age. 98.6% of men had bitemporal recession and severity was significantly associated with vertex and mid-frontal hair loss (p <0.01) but not age (p = 0.06). In all, 64.4% of women had bitemporal hair loss, and similar to men there was a significant association with mid-frontal hair loss (p =0.042) but not age (p =0.467). One hundred and forty children with completed questionnaires were examined. All 72 females and 68 males were assessed as stage 1 on the mid-line part and with no bitemporal recession (frequency stage 1 = 100%, 95% CI (confidence interval) 97.4%-100%). A significant but weak positive association existed between presence of gray hair and history of dandruff (p< | + | Additional data was collected on dandruff, presence of gray hair. Supplementary questionnaires were sent to 340 children aged 5-9, attending a coeducational primary school. 1456 adults (34.1%) responded to the questionnaire. 396 attended for examination. The prevalence of androgenetic alopecia (AGA) increased with advancing age. 98.6% of men had bitemporal recession and severity was significantly associated with vertex and mid-frontal hair loss (p <0.01) but not age (p = 0.06). In all, 64.4% of women had bitemporal hair loss, and similar to men there was a significant association with mid-frontal hair loss (p =0.042) but not age (p =0.467). One hundred and forty children with completed questionnaires were examined. All 72 females and 68 males were assessed as stage 1 on the mid-line part and with no bitemporal recession (frequency stage 1 = 100%, 95% CI (confidence interval) 97.4%-100%). A significant but weak positive association existed between presence of gray hair and history of dandruff (p< |
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===== Members' | ===== Members' | ||
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Br J Vener Dis. 1977 Dec; | Br J Vener Dis. 1977 Dec; | ||
- | Pareek SS. (({{pubmed> | + | Pareek SS. (({{pmid> |
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Alopecia syphilitica with detection of Treponema pallidum in the hair follicle. | Alopecia syphilitica with detection of Treponema pallidum in the hair follicle. | ||
Nam-Cha SH, Guhl G, Fernández-Peña P, Fraga J. | Nam-Cha SH, Guhl G, Fernández-Peña P, Fraga J. | ||
- | J Cutan Pathol. 2007 Dec;34 Suppl 1: | + | J Cutan Pathol. 2007 Dec;34 Suppl 1: |
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Cutaneous Mycobacterium neoaurum infection causing scarring alopecia in an immunocompetent host. | Cutaneous Mycobacterium neoaurum infection causing scarring alopecia in an immunocompetent host. | ||
Martin LK, Lawrence R, Kossard S, Murrell DF. | Martin LK, Lawrence R, Kossard S, Murrell DF. | ||
- | Br J Dermatol. 2007 Jul; | + | Br J Dermatol. 2007 Jul; |
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[Scarring tinea profunda in the pubic area due to Trichophyton verrucosum] | [Scarring tinea profunda in the pubic area due to Trichophyton verrucosum] | ||
Grunewald S, Paasch U, Gräser Y, Glander HJ, Simon JC, Nenoff P. | Grunewald S, Paasch U, Gräser Y, Glander HJ, Simon JC, Nenoff P. | ||
- | Hautarzt. 2006 Sep; | + | Hautarzt. 2006 Sep; |
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PSA screening for prostate cancer is generally not begun until men are in their 40s and 50s, but Giraud and Yassa suggested that it might be useful to start it somewhat earlier for men who go bald in their 20s because of their increased risk. Experts cautioned, however, that the number of people involved in the study was small, so the results should be interpreted with care. | PSA screening for prostate cancer is generally not begun until men are in their 40s and 50s, but Giraud and Yassa suggested that it might be useful to start it somewhat earlier for men who go bald in their 20s because of their increased risk. Experts cautioned, however, that the number of people involved in the study was small, so the results should be interpreted with care. | ||
- | Other risk factors for prostate cancer include age, family history of the disease, diet, lifestyle and ethnicity. | + | Other risk factors for prostate cancer include age, family history of the disease, diet, lifestyle and ethnicity. |
</ | </ | ||
===== Role of vitamin D ===== | ===== Role of vitamin D ===== | ||
- | Dermatol Online J. 2010 Feb 15;16(2):3. | ||
- | Does D matter? The role of vitamin D in hair disorders and hair follicle cycling. | ||
- | Amor KT, Rashid RM, Mirmirani P. | ||
- | Department of Dermatology, | + | BACKGROUND: The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology. OBJECTIVE: We sought to evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair disorders. |
- | BACKGROUND: The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology. OBJECTIVE: We sought to evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair disorders. | + | |
- | < | + | METHODS: A MEDLINE search (1955-July 2009) was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss. RESULTS: The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood. |
- | https:// | + | |
- | The hair cycle and Vitamin D receptor. (({{pubmed> | + | LIMITATIONS: |
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+ | From: Bane, date: 2011-10-20 [[https:// | ||
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The Vitamin D receptor (VDR) plays a critical role in epidermal homeostasis. The ligand-dependent actions of the VDR attenuate epidermal keratinocyte proliferation and promote keratinocyte differentiation. Calcium can compensate for the absence of the VDR in maintaining a normal program of epidermal keratinocyte differentiation both in vitro and in vivo. In contrast, the effects of VDR ablation on the hair follicle cannot be prevented by maintaining normal calcium levels and are independent of 1, | The Vitamin D receptor (VDR) plays a critical role in epidermal homeostasis. The ligand-dependent actions of the VDR attenuate epidermal keratinocyte proliferation and promote keratinocyte differentiation. Calcium can compensate for the absence of the VDR in maintaining a normal program of epidermal keratinocyte differentiation both in vitro and in vivo. In contrast, the effects of VDR ablation on the hair follicle cannot be prevented by maintaining normal calcium levels and are independent of 1, | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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* legacy content | * legacy content | ||
* | * | ||
- | * [[http:// | + | * [[https:// |
+ | ===== References =====</ | ||
- | ===== References ===== |