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home:diseases:alopecia [02.18.2019] – [Role of vitamin D] sallieqhome:diseases:alopecia [02.19.2019] – [Baldness (alopecia)] sallieq
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 ====== Baldness (alopecia) ====== ====== Baldness (alopecia) ======
  
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 +<relatedarticle>  [[home:symptoms:grayhair#evidence_of_infectious_cause|gray hair]]</article> 
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 +===== Introduction =====
  
 __In search of the "hair cycle clock": a guided tour__ __In search of the "hair cycle clock": a guided tour__
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 "Vertex baldness, but not frontal baldness, is associated with an increased risk of chronic heart disease. The association with CHD depends on the severity of vertex baldness and also exists among younger men"(({{pubmed>long:23554099}})) "Vertex baldness, but not frontal baldness, is associated with an increased risk of chronic heart disease. The association with CHD depends on the severity of vertex baldness and also exists among younger men"(({{pubmed>long:23554099}}))
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-<relatedarticle>  [[home:symptoms:grayhair#evidence_of_infectious_cause|gray hair]]</article>  
  
  
 +[[http://www.bbc.co.uk/news/health-12112673|Cause of male baldness discovered, experts say]]
  
 ===== Members' experiences ===== ===== Members' experiences =====
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 LIMITATIONS: The review is broad and there are limited human studies available to date. CONCLUSION: Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.  (({{pubmed>long:20178699}})) LIMITATIONS: The review is broad and there are limited human studies available to date. CONCLUSION: Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.  (({{pubmed>long:20178699}}))
  
-<blockquote>From: Bane, date: 2011-10-20 https://www.marshallprotocol.com/forum43/10978.html+From: Bane, date: 2011-10-20 [[https://www.marshallprotocol.com/forum43/10978.html|VDR's transcription of genes]] 
  
-The hair cycle and Vitamin D receptor. (({{pubmed>long:22008469}}))+<blockquote>The hair cycle and Vitamin D receptor. (({{pubmed>long:22008469}}))
  
 The Vitamin D receptor (VDR) plays a critical role in epidermal homeostasis. The ligand-dependent actions of the VDR attenuate epidermal keratinocyte proliferation and promote keratinocyte differentiation. Calcium can compensate for the absence of the VDR in maintaining a normal program of epidermal keratinocyte differentiation both in vitro and in vivo. In contrast, the effects of VDR ablation on the hair follicle cannot be prevented by maintaining normal calcium levels and are independent of 1,25-dihydroxyvitamin D. These actions of the VDR are critical in the keratinocyte stem cell population that resides in the bulge region of the hair follicle. Absence of a functional VDR leads to a self-renewal and lineage progression defect in this population of stem cells, resulting in the absence of post-morphogenic hair cycles. The molecular partners and downstream target genes of the VDR in this unique population of cells have not yet been identified.   The Vitamin D receptor (VDR) plays a critical role in epidermal homeostasis. The ligand-dependent actions of the VDR attenuate epidermal keratinocyte proliferation and promote keratinocyte differentiation. Calcium can compensate for the absence of the VDR in maintaining a normal program of epidermal keratinocyte differentiation both in vitro and in vivo. In contrast, the effects of VDR ablation on the hair follicle cannot be prevented by maintaining normal calcium levels and are independent of 1,25-dihydroxyvitamin D. These actions of the VDR are critical in the keratinocyte stem cell population that resides in the bulge region of the hair follicle. Absence of a functional VDR leads to a self-renewal and lineage progression defect in this population of stem cells, resulting in the absence of post-morphogenic hair cycles. The molecular partners and downstream target genes of the VDR in this unique population of cells have not yet been identified.  
home/diseases/alopecia.txt · Last modified: 09.14.2022 by 127.0.0.1
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