You are here: Welcome to the MPKB » Welcome to the MPKB » Diseases » Baldness (alopecia)
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
home:diseases:alopecia [02.19.2019] – [Baldness (alopecia)] sallieqhome:diseases:alopecia [09.14.2022] (current) – external edit 127.0.0.1
Line 16: Line 16:
  
 Here, we sketch basic background information and key concepts that one needs to keep in mind when exploring the enigmatic "hair cycle clock"(HCC), and summarize competing models of the HCC. We invite the reader on a very subjective guided tour, which focuses on our own trials, errors, and findings toward the distant goal of unravelling one of the most fascinating mysteries of biology: Why does the hair follicle cycle at all? How does it do it? What are the key players in the underlying molecular controls? Attempting to offer at least some meaningful answers, we share our prejudices and perspectives, and define crucial open questions. Here, we sketch basic background information and key concepts that one needs to keep in mind when exploring the enigmatic "hair cycle clock"(HCC), and summarize competing models of the HCC. We invite the reader on a very subjective guided tour, which focuses on our own trials, errors, and findings toward the distant goal of unravelling one of the most fascinating mysteries of biology: Why does the hair follicle cycle at all? How does it do it? What are the key players in the underlying molecular controls? Attempting to offer at least some meaningful answers, we share our prejudices and perspectives, and define crucial open questions.
-(({{pubmed>long:    15617561}}))  +(({{pmid>long:    15617561}}))  
  
  
Line 24: Line 24:
 Maryborough, in central Victoria has an approximate population of 8000 and census data is well matched for Australia overall. Australia has compulsory voting and registration on the electoral roll. To determine the age-related prevalence of balding among men and women in Maryborough we conducted a postal survey of 5000 men and women aged 20 or older, and 427 were invited to attend for examination.  Maryborough, in central Victoria has an approximate population of 8000 and census data is well matched for Australia overall. Australia has compulsory voting and registration on the electoral roll. To determine the age-related prevalence of balding among men and women in Maryborough we conducted a postal survey of 5000 men and women aged 20 or older, and 427 were invited to attend for examination. 
  
-Additional data was collected on dandruff, presence of gray hair. Supplementary questionnaires were sent to 340 children aged 5-9, attending a coeducational primary school. 1456 adults (34.1%) responded to the questionnaire. 396 attended for examination. The prevalence of androgenetic alopecia (AGA) increased with advancing age. 98.6% of men had bitemporal recession and severity was significantly associated with vertex and mid-frontal hair loss (p <0.01) but not age (p = 0.06). In all, 64.4% of women had bitemporal hair loss, and similar to men there was a significant association with mid-frontal hair loss (p =0.042) but not age (p =0.467). One hundred and forty children with completed questionnaires were examined. All 72 females and 68 males were assessed as stage 1 on the mid-line part and with no bitemporal recession (frequency stage 1 = 100%, 95% CI (confidence interval) 97.4%-100%). A significant but weak positive association existed between presence of gray hair and history of dandruff (p<0.01). The prevalence of mid-frontal hair loss increases with age and affects 57% of women and 73.5% of men aged 80 and over.  (({{pubmed>long:16382660}}))+Additional data was collected on dandruff, presence of gray hair. Supplementary questionnaires were sent to 340 children aged 5-9, attending a coeducational primary school. 1456 adults (34.1%) responded to the questionnaire. 396 attended for examination. The prevalence of androgenetic alopecia (AGA) increased with advancing age. 98.6% of men had bitemporal recession and severity was significantly associated with vertex and mid-frontal hair loss (p <0.01) but not age (p = 0.06). In all, 64.4% of women had bitemporal hair loss, and similar to men there was a significant association with mid-frontal hair loss (p =0.042) but not age (p =0.467). One hundred and forty children with completed questionnaires were examined. All 72 females and 68 males were assessed as stage 1 on the mid-line part and with no bitemporal recession (frequency stage 1 = 100%, 95% CI (confidence interval) 97.4%-100%). A significant but weak positive association existed between presence of gray hair and history of dandruff (p<0.01). The prevalence of mid-frontal hair loss increases with age and affects 57% of women and 73.5% of men aged 80 and over.  (({{pmid>long:16382660}}))
  
          
-"Vertex baldness, but not frontal baldness, is associated with an increased risk of chronic heart disease. The association with CHD depends on the severity of vertex baldness and also exists among younger men"(({{pubmed>long:23554099}}))+"Vertex baldness, but not frontal baldness, is associated with an increased risk of chronic heart disease. The association with CHD depends on the severity of vertex baldness and also exists among younger men"(({{pmid>long:23554099}}))
  
  
-[[http://www.bbc.co.uk/news/health-12112673|Cause of male baldness discovered, experts say]]+[[https://www.bbc.co.uk/news/health-12112673|Cause of male baldness discovered, experts say]]
  
 ===== Members' experiences ===== ===== Members' experiences =====
Line 94: Line 94:
  
 Br J Vener Dis. 1977 Dec;53(6):389-90.Syphilitic alopecia and Jarisch-Herxheimer reaction. Br J Vener Dis. 1977 Dec;53(6):389-90.Syphilitic alopecia and Jarisch-Herxheimer reaction.
-Pareek SS.  (({{pubmed>long:606336}}))+Pareek SS.  (({{pmid>long:606336}}))
  
  
Line 107: Line 107:
 Alopecia syphilitica with detection of Treponema pallidum in the hair follicle. Alopecia syphilitica with detection of Treponema pallidum in the hair follicle.
 Nam-Cha SH, Guhl G, Fernández-Peña P, Fraga J. Nam-Cha SH, Guhl G, Fernández-Peña P, Fraga J.
-J Cutan Pathol. 2007 Dec;34 Suppl 1:37-40.  (({{pubmed>long:17997737}}))+J Cutan Pathol. 2007 Dec;34 Suppl 1:37-40.  (({{pmid>long:17997737}}))
  
  
Line 113: Line 113:
 Cutaneous Mycobacterium neoaurum infection causing scarring alopecia in an immunocompetent host. Cutaneous Mycobacterium neoaurum infection causing scarring alopecia in an immunocompetent host.
 Martin LK, Lawrence R, Kossard S, Murrell DF. Martin LK, Lawrence R, Kossard S, Murrell DF.
-Br J Dermatol. 2007 Jul;157(1):204-6. Epub 2007 May 14. No abstract available.  (({{pubmed>long:17501949}}))+Br J Dermatol. 2007 Jul;157(1):204-6. Epub 2007 May 14. No abstract available.  (({{pmid>long:17501949}}))
  
  
Line 119: Line 119:
 [Scarring tinea profunda in the pubic area due to Trichophyton verrucosum] [Scarring tinea profunda in the pubic area due to Trichophyton verrucosum]
 Grunewald S, Paasch U, Gräser Y, Glander HJ, Simon JC, Nenoff P. Grunewald S, Paasch U, Gräser Y, Glander HJ, Simon JC, Nenoff P.
-Hautarzt. 2006 Sep;57(9):811-3. German.  (({{pubmed>long:16402270}}))+Hautarzt. 2006 Sep;57(9):811-3. German.  (({{pmid>long:16402270}}))
  
  
Line 137: Line 137:
 PSA screening for prostate cancer is generally not begun until men are in their 40s and 50s, but Giraud and Yassa suggested that it might be useful to start it somewhat earlier for men who go bald in their 20s because of their increased risk. Experts cautioned, however, that the number of people involved in the study was small, so the results should be interpreted with care. PSA screening for prostate cancer is generally not begun until men are in their 40s and 50s, but Giraud and Yassa suggested that it might be useful to start it somewhat earlier for men who go bald in their 20s because of their increased risk. Experts cautioned, however, that the number of people involved in the study was small, so the results should be interpreted with care.
  
-Other risk factors for prostate cancer include age, family history of the disease, diet, lifestyle and ethnicity.    (({{pubmed>long:30764008}}))  +Other risk factors for prostate cancer include age, family history of the disease, diet, lifestyle and ethnicity.    (({{pmid>long:30764008}}))  
 </blockquote> </blockquote>
  
Line 147: Line 147:
 METHODS: A MEDLINE search (1955-July 2009) was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss. RESULTS: The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood.  METHODS: A MEDLINE search (1955-July 2009) was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss. RESULTS: The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood. 
  
-LIMITATIONS: The review is broad and there are limited human studies available to date. CONCLUSION: Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.  (({{pubmed>long:20178699}}))+LIMITATIONS: The review is broad and there are limited human studies available to date. CONCLUSION: Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.  (({{pmid>long:20178699}}))
  
 From: Bane, date: 2011-10-20 [[https://www.marshallprotocol.com/forum43/10978.html|VDR's transcription of genes]] From: Bane, date: 2011-10-20 [[https://www.marshallprotocol.com/forum43/10978.html|VDR's transcription of genes]]
  
  
-<blockquote>The hair cycle and Vitamin D receptor. (({{pubmed>long:22008469}}))+<blockquote>The hair cycle and Vitamin D receptor. (({{pmid>long:22008469}}))
  
 The Vitamin D receptor (VDR) plays a critical role in epidermal homeostasis. The ligand-dependent actions of the VDR attenuate epidermal keratinocyte proliferation and promote keratinocyte differentiation. Calcium can compensate for the absence of the VDR in maintaining a normal program of epidermal keratinocyte differentiation both in vitro and in vivo. In contrast, the effects of VDR ablation on the hair follicle cannot be prevented by maintaining normal calcium levels and are independent of 1,25-dihydroxyvitamin D. These actions of the VDR are critical in the keratinocyte stem cell population that resides in the bulge region of the hair follicle. Absence of a functional VDR leads to a self-renewal and lineage progression defect in this population of stem cells, resulting in the absence of post-morphogenic hair cycles. The molecular partners and downstream target genes of the VDR in this unique population of cells have not yet been identified.   The Vitamin D receptor (VDR) plays a critical role in epidermal homeostasis. The ligand-dependent actions of the VDR attenuate epidermal keratinocyte proliferation and promote keratinocyte differentiation. Calcium can compensate for the absence of the VDR in maintaining a normal program of epidermal keratinocyte differentiation both in vitro and in vivo. In contrast, the effects of VDR ablation on the hair follicle cannot be prevented by maintaining normal calcium levels and are independent of 1,25-dihydroxyvitamin D. These actions of the VDR are critical in the keratinocyte stem cell population that resides in the bulge region of the hair follicle. Absence of a functional VDR leads to a self-renewal and lineage progression defect in this population of stem cells, resulting in the absence of post-morphogenic hair cycles. The molecular partners and downstream target genes of the VDR in this unique population of cells have not yet been identified.  
Line 160: Line 160:
  
  
-{{tag>diseases arrange}}+{{tag>diseases }}
  
  
  
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
Line 176: Line 177:
   * legacy content   * legacy content
   *    * 
-  * [[http://www.bbc.co.uk/news/health-12112673|Cause of male baldness discovered, experts say]]+  * [[https://www.bbc.co.uk/news/health-12112673|Cause of male baldness discovered, experts say]]
  
  
  
-===== References =====+===== References =====</nodisp> 
home/diseases/alopecia.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.