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home:diseases:anemia [06.28.2014] – [Management] jj | home:diseases:anemia [01.11.2019] – [Anemia] sallieq | ||
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====== Anemia ====== | ====== Anemia ====== | ||
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+ | ===== Introduction ===== | ||
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Anemia of chronic disease, also referred to as anemia of inflammatory response, is a common condition seen in chronic illness.(({{pubmed> | Anemia of chronic disease, also referred to as anemia of inflammatory response, is a common condition seen in chronic illness.(({{pubmed> | ||
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* **total iron binding capacity (TIBC)** – Shows if there is the "right amount" | * **total iron binding capacity (TIBC)** – Shows if there is the "right amount" | ||
* **soluble transferrin receptor (sTfR)** – Relatively new test. While standard measures of iron status such as ferritin, total iron-binding capacity, and serum iron are directly affected by chronic disease sTfR is elevated in iron deficiency but is not appreciably affected by chronic disease. A good way to verify anemia of chronic desease because it is not affected by inflammation. Should be considered for anemic patients whose differential diagnosis includes iron deficiency and anemia of inflammatory disease. | * **soluble transferrin receptor (sTfR)** – Relatively new test. While standard measures of iron status such as ferritin, total iron-binding capacity, and serum iron are directly affected by chronic disease sTfR is elevated in iron deficiency but is not appreciably affected by chronic disease. A good way to verify anemia of chronic desease because it is not affected by inflammation. Should be considered for anemic patients whose differential diagnosis includes iron deficiency and anemia of inflammatory disease. | ||
- | * **hemoglobin** – The iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates. The effect of locking up iron stores is to reduce the ability of the bone marrow to produce red blood cells. These cells require iron for their massive amounts of hemoglobin which allow them to transport oxygen. | + | * **hemoglobin |
- | * **hematocrit** – A measure of the number of red blood cells and the size of red blood cells. It gives a percentage of red blood cells found in whole blood. Most automated cell counters measure the hemoglobin directly, but the hematocrit is calculated. Generally, therefore, it is probably more reliable to base clinical decisions on the hemoglobin concentration. | + | * **hematocrit |
* **erythropoietin (EPO)** – Erythropoietin is not a routine test. It is ordered primarily to help differentiate between different types of anemia and to determine whether the amount of erythropoietin being produced is appropriate for the level of anemia present. Low EPO in patients on olmesartan might largely be due to better blood flow and oxygenation in kidneys since the olmesartan blocks the angiotensin II receptors. This would have an effect superimposed on anemia of chronic disease which is caused by immunopathology. | * **erythropoietin (EPO)** – Erythropoietin is not a routine test. It is ordered primarily to help differentiate between different types of anemia and to determine whether the amount of erythropoietin being produced is appropriate for the level of anemia present. Low EPO in patients on olmesartan might largely be due to better blood flow and oxygenation in kidneys since the olmesartan blocks the angiotensin II receptors. This would have an effect superimposed on anemia of chronic disease which is caused by immunopathology. | ||
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Once I started thyroxine my life turned around, as I got most of my energy back and my thinning hair started growing back - but my arthritis was as bad as ever. | Once I started thyroxine my life turned around, as I got most of my energy back and my thinning hair started growing back - but my arthritis was as bad as ever. | ||
- | Fast forward 1 year - I found the MP and began phase one. Within days of starting mino I began to experience a metallic taste in my mouth. Could that metallic taste be ... metal? | + | Fast forward 1 year - I found the MP and began phase one. Within days of starting mino I began to experience a metallic taste in my mouth. Could that metallic taste be ... metal? |
I reckon all those iron-sequestering CWD monsters were dying and giving up all the iron back into my bloodstream. After a couple of months, my ferritin levels came down to normal again and the metallic taste went away at the same time. | I reckon all those iron-sequestering CWD monsters were dying and giving up all the iron back into my bloodstream. After a couple of months, my ferritin levels came down to normal again and the metallic taste went away at the same time. |