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home:diseases:ankylosing_spondylitis [02.10.2019] – [Ankylosing spondylitis] sallieqhome:diseases:ankylosing_spondylitis [09.14.2022] (current) – external edit 127.0.0.1
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 <relatedarticle> [[home:diseases:rheumatoid_arthritis|Arthritis]] </article> <relatedarticle> [[home:diseases:rheumatoid_arthritis|Arthritis]] </article>
  
-===== Introduction ===== 
  
-//from// [[https://medical-dictionary.thefreedictionary.com|the free dictionary]]...+ 
 +//from// [[https://medical-dictionary.thefreedictionary.com|medical-dictionary.the free dictionary]]...
  
 A form of arthritis, AS is characterized by chronic inflammation, causing pain and stiffness of the back, progressing to the chest and neck. Eventually, the whole back may become curved and inflexible if the bones fuse (this is known as "bamboo spine"). AS is a systemic disorder that may involve multiple organs, such as the: A form of arthritis, AS is characterized by chronic inflammation, causing pain and stiffness of the back, progressing to the chest and neck. Eventually, the whole back may become curved and inflexible if the bones fuse (this is known as "bamboo spine"). AS is a systemic disorder that may involve multiple organs, such as the:
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 [[https://medlineplus.gov/ency/article/003551.htm|HLA-B27]] a blood test to look for a protein that is found on the surface of white blood cells. The protein is called human leukocyte antigen B27 (HLA-B27). [[https://medlineplus.gov/ency/article/003551.htm|HLA-B27]] a blood test to look for a protein that is found on the surface of white blood cells. The protein is called human leukocyte antigen B27 (HLA-B27).
  
-==== Standard treatments ====+==== Immune suppression ====
  
 Injections used in standard medical treatment are seriously immune suppressant  Injections used in standard medical treatment are seriously immune suppressant 
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 CONCLUSION: The role of K. pneumoniae and anti-collagen antibodies in the aetiopathogenesis of CD and AS requires further study. CONCLUSION: The role of K. pneumoniae and anti-collagen antibodies in the aetiopathogenesis of CD and AS requires further study.
-(({{pubmed>long:11157137}}))</blockquote>+(({{pmid>long:11157137}}))</blockquote>
  
 [[https://ard.bmj.com/content/76/6/1123.abstract?utm_term=usage-012019&utm_content=consumer&utm_campaign=ard&utm_medium=cpc&utm_source=trendmd|Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis ]] [[https://ard.bmj.com/content/76/6/1123.abstract?utm_term=usage-012019&utm_content=consumer&utm_campaign=ard&utm_medium=cpc&utm_source=trendmd|Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis ]]
 ===== Management ===== ===== Management =====
  
-The prevalence rate of hip involvement in AS patients varies from 10 to 23%, depending on the type of hip assessment. TNF-α blocking therapy significantly improved tender hip joints, and inflammatory US lesions including positive power Doppler.   (({{pubmed>long:30624693}}))+The prevalence rate of hip involvement in AS patients varies from 10 to 23%, depending on the type of hip assessment. TNF-α blocking therapy significantly improved tender hip joints, and inflammatory US lesions including positive power Doppler.   (({{pmid>long:30624693}}))
  
  
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 Patients with ankylosing spondylitis (AS) warrant a comprehensive clinical assessment because of the lack of biomarkers of disease activity, prognosis and response to biologic therapy. Multiple AS-related questionnaires have been developed to assess the disease status accurately, but feasibility remains a problem in clinical practice.  Patients with ankylosing spondylitis (AS) warrant a comprehensive clinical assessment because of the lack of biomarkers of disease activity, prognosis and response to biologic therapy. Multiple AS-related questionnaires have been developed to assess the disease status accurately, but feasibility remains a problem in clinical practice. 
  
-The Bath Ankylosing Disease Activity Index remains the gold standard for assessing disease activity in a routine practice, despite poor correlation with C-reactive protein (CRP) levels and MRI inflammation.   (({{pubmed>long:30624284}}))+The Bath Ankylosing Disease Activity Index remains the gold standard for assessing disease activity in a routine practice, despite poor correlation with C-reactive protein (CRP) levels and MRI inflammation.   (({{pmid>long:30624284}}))
  
-==== Headline ==== 
  
-<blockquote> I have found an orange juice with calcium and NO D!   I also found a lactose fat free milk (LandOLakes) D free ....with calcium.  It is called Dairy Ease.  Perfect for this lactose intolerant, D free, calcium deficient 
- 
- I do fair better with fortified calcium foods than I do calcium supplements!   I tend to get pains in my back if I take more than 800 mgs of calcium daily in pill form.  But I am determined to get my bones stronger</blockquote> 
  
 ==== TNF inhibitor dose ====  ==== TNF inhibitor dose ==== 
  
-In patients with ankylosing spondylitis in clinical remission for at least 6 months, dose reduction is non-inferior to full TNF inhibitor doses to maintain LDA after 1 year. Serious adverse events may be less frequent with reduced doses.   (({{pubmed>long:30621746}})) +In patients with ankylosing spondylitis in clinical remission for at least 6 months, dose reduction is non-inferior to full TNF inhibitor doses to maintain LDA after 1 year. Serious adverse events may be less frequent with reduced doses.   (({{pmid>long:30621746}})) 
  
  
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 <blockquote> I was on Fosamax for 2 years, which lead to acid reflux and the need for Prilosec.  My primary doc was obviously wrong then, as I believe he is now when he recommends 1000mg of Vitamin D daily.  Been there and done that already with very bad results.  I don't argue with my doc, but I make my own educated health decisions.  Most of our current medical insight seems to be blinded by the "sunshine vitamin syndrome" //Jasmine//</blockquote> <blockquote> I was on Fosamax for 2 years, which lead to acid reflux and the need for Prilosec.  My primary doc was obviously wrong then, as I believe he is now when he recommends 1000mg of Vitamin D daily.  Been there and done that already with very bad results.  I don't argue with my doc, but I make my own educated health decisions.  Most of our current medical insight seems to be blinded by the "sunshine vitamin syndrome" //Jasmine//</blockquote>
 +
 +==== D-free calcium ====
 +
 +<blockquote> I have found an orange juice with calcium and NO D!   I also found a lactose fat free milk (LandOLakes) D free ....with calcium.  It is called Dairy Ease.  Perfect for this lactose intolerant, D free, calcium deficient
 +
 + I do fair better with fortified calcium foods than I do calcium supplements!   I tend to get pains in my back if I take more than 800 mgs of calcium daily in pill form.  But I am determined to get my bones stronger</blockquote>
  
  
 ==== Related research on osteonecrosis ==== ==== Related research on osteonecrosis ====
  
-The findings from this study indicated that even short-term oral use of alendronate led to ONJ in a subset of patients after certain dental procedures were performed. These findings have important therapeutic and preventive implications.   (({{pubmed>long:19119168}}))+The findings from this study indicated that even short-term oral use of alendronate led to ONJ in a subset of patients after certain dental procedures were performed. These findings have important therapeutic and preventive implications.   (({{pmid>long:19119168}}))
  
-Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw   (({{pubmed>long:30534822}}))+Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw   (({{pmid>long:30534822}}))
  
    
 {{tag>diseases }} {{tag>diseases }}
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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 <blockquote>Arthritis Rheum. 2009 Nov;60(11):3519-20; author reply 3520-1. <blockquote>Arthritis Rheum. 2009 Nov;60(11):3519-20; author reply 3520-1.
  
-Time to prove the infective etiology of ankylosing spondylitis and related spondylarthritides: Comment on the article by Carter et al.(({{pubmed>long:19877074}}))+Time to prove the infective etiology of ankylosing spondylitis and related spondylarthritides: Comment on the article by Carter et al.(({{pmid>long:19877074}}))
  
 Zeidler H, Rihl M. Zeidler H, Rihl M.
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 </blockquote> </blockquote>
  
-===== References =====+===== References =====</nodisp> 
home/diseases/ankylosing_spondylitis.txt · Last modified: 09.14.2022 by 127.0.0.1
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