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home:diseases:anxiety [05.02.2011] – external edit 127.0.0.1 | home:diseases:anxiety [01.26.2020] – [Research into various drug effects] sallieq | ||
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Anxiety or anxiety disorder is a common co-morbidity of patients sufferings from chronic inflammatory diseases. Like all inflammatory diseases, anxiety disorder is caused by the Th1 pathogens and may temporarily increase during periods of immunopathology. Cognitive dysfunction can be managed using the [[home: | Anxiety or anxiety disorder is a common co-morbidity of patients sufferings from chronic inflammatory diseases. Like all inflammatory diseases, anxiety disorder is caused by the Th1 pathogens and may temporarily increase during periods of immunopathology. Cognitive dysfunction can be managed using the [[home: | ||
- | Anxiety can be subtle or debilitating or both. Some patients may not possess the presence of mind to know they' | + | Anxiety can be subtle or debilitating or both. Some patients may not possess the presence of mind to know they' |
Patients suffering from anxiety may wish to modify their dose of antibiotics or take an [[home: | Patients suffering from anxiety may wish to modify their dose of antibiotics or take an [[home: | ||
- | ===== Evidence of infectious cause ===== | ||
- | Mark Lyte of the Texas Tech University School of Pharmacy noticed that lab mice dosed with // | ||
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- | //**L.E. Goehler** et al.// | ||
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- | The frequency with which patients of certain Th1 diseases also experience anxiety(({{pubmed> | ||
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- | It is my opinion that early and prominent symptoms of Th1 disease are psychological which have been interpreted as anxiety, depression, insomnia, learning disabilities etc. These symptoms like physical ones are exacerbated during effective treatment of Th1 [diseases]. | ||
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- | By understanding this, one can lessen some of the impact of those symptoms, just as one can with the physical symptoms. Not knowing why one is ' | ||
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- | //**Greg Blaney, MD**// </ | ||
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Anxiety can and should be managed just like other symptoms. The following strategies and therapies may limit or help manage the anxiety a patient experiences | Anxiety can and should be managed just like other symptoms. The following strategies and therapies may limit or help manage the anxiety a patient experiences | ||
* Restrict light exposure. It is very common for MP patients to experience anxiety in the hours or days following light exposure. | * Restrict light exposure. It is very common for MP patients to experience anxiety in the hours or days following light exposure. | ||
- | * Modify doses of antibiotics. | + | |
+ | * Go for a walk. | ||
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* Take an [[home: | * Take an [[home: | ||
* Practice good sleep hygiene. | * Practice good sleep hygiene. | ||
- | * Try relaxation techniques. | + | * Learn relaxation techniques. |
* Listen to soothing music. | * Listen to soothing music. | ||
* Try [[home: | * Try [[home: | ||
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//**John McDonald**// | //**John McDonald**// | ||
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- | The first few months on Phase Two were the most difficult for me. Anything connected with emotion was difficult and when it came to physical things, I felt sluggish - as if were doing everything in a swimming pool, working against the force of water. Mental confusion and despair may be better if you rest more and keep in mind that this is // | ||
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- | //**Belinda Fenter**// </ | ||
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Interviews of patients with other diseases are [[home: | Interviews of patients with other diseases are [[home: | ||
+ | ===== Evidence of infectious cause ===== | ||
+ | Mark Lyte of the Texas Tech University School of Pharmacy noticed that lab mice dosed with // | ||
+ | < | ||
+ | //**L.E. Goehler** et al.// | ||
+ | Further, Neufeld //et al.// showed that germ-free mice exhibited reduced anxiety-like behavior as well as significant neurochemical changes in the brain compared to specific-pathogen-free mice. (({{pubmed> | ||
+ | The frequency with which patients of certain Th1 diseases also experience anxiety(({{pubmed> | ||
+ | < | ||
+ | It is my opinion that early and prominent symptoms of Th1 disease are psychological which have been interpreted as anxiety, depression, insomnia, learning disabilities etc. These symptoms like physical ones are exacerbated during effective treatment of Th1 [diseases]. | ||
+ | By understanding this, one can lessen some of the impact of those symptoms, just as one can with the physical symptoms. Not knowing why one is ' | ||
+ | //**Greg Blaney, MD**// </ | ||
+ | ===== Research into various drug effects ===== | ||
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+ | baseline symptoms of depression (but not anxiety or stress) appeared to be exacerbated across time/ | ||
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+ | Perhaps most well-studied is the role the CeA plays in unconditioned and conditioned fear generation (Ciocchi et al., 2010, Li et al., 2013, Tye et al., 2011), fear extinction, and conditioned inhibition (Amano et al., 2010), as well as conditioned orienting responses to emotionally salient stimuli (El-Amamy and Holland, 2007, Groshek et al., 2005). | ||
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+ | the mechanisms by which stress increases amygdala-dmPFC synaptic strength and generates anxiety-like behaviors are not well understood. Here, we show that the mouse basolateral amygdala (BLA)-prelimbic prefrontal cortex (plPFC) circuit is engaged by stress and activation of this pathway in anxiogenic. [[https:// | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
< | < | ||
- | EDIT | + | |
* Legacy content | * Legacy content | ||
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PMID: 17920243</ | PMID: 17920243</ | ||
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+ | Mice raised in a sterile environment were much bolder, literally going out on a ledge more often than mice reared with bacteria in their bellies, Pettersson’s team reported in the Feb. 15 Proceedings of the National Academy of Sciences. Bacteria-free mice were also more active overall than their bacteria-laden counterparts. Inoculating bacteria-free newborn mice with intestinal bacteria reversed the changes in behavior. But restoring gut bacteria in adult bacteria-free mice did not change the rodents’ behavior, indicating that whatever bacteria do to the brain, they do it early in life. | ||
+ | Bacteria’s presence or absence affected how the mice used certain brain chemicals and genes involved in brain development. Taken together, the results indicate that intestinal bacteria somehow shape the brain and make mice more anxious — or cautious, depending how you look at it, Pettersson says. | ||
+ | </ | ||
===== References ===== | ===== References ===== |