Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
home:diseases:anxiety [08.13.2019]
sallieq [Evidence of infectious cause]
home:diseases:anxiety [08.13.2019]
sallieq [Patient interviews]
Line 101: Line 101:
 Interviews of patients with other diseases are [[home:​patients:​patient_interviews|also available]]. Interviews of patients with other diseases are [[home:​patients:​patient_interviews|also available]].
  
 +===== Evidence of infectious cause =====
  
 +Mark Lyte of the Texas Tech University School of Pharmacy noticed that lab mice dosed with //​Campylobacter jejuni//, bacteria that are commonly a cause of food poisoning, were more anxious than control mice. After several experiments,​ Lyte’s team concluded that the vagus nerve, which extends into the colon, was probably transmitting the news of a gut infection to the brain areas involved in emotions. Reporting their results in the August 2007 //Brain, Behavior and Immunity//, the team also conjectured that the anxiety often exhibited by victims of bowel disorders may operate on the same network, which is not under conscious control:
  
 +<​blockquote>​Infection and inflammation lead to changes in mood and cognition. Although the "​classic"​ sickness behavior syndrome, involving fatigue, social withdrawal, and loss of appetites are most familiar, other emotional responses accompany immune activation, including anxiety. Recent studies have shown that gastrointestinal bacterial infections lead to enhanced anxiety-like behavior in mice. The bacteria-induced signal is most likely carried by vagal sensory neurons, and occurs early on (within 6h) during the infection. These signals induce evidence of activation in brain regions that integrate viscerosensory information with mood, and potentiate activation in brain regions established as key players in fear and anxiety. ​
  
 +//**L.E. Goehler** et al.//​(({{pubmed>​long:​17428636}}))</​blockquote>​
  
 +Further, Neufeld //et al.// showed that germ-free mice exhibited reduced anxiety-like behavior as well as significant neurochemical changes in the brain compared to specific-pathogen-free mice. (({{pubmed>​long:​21054680}}))
  
  
  
 +The frequency with which patients of certain Th1 diseases also experience anxiety(({{pubmed>​long:​8818377}})) (({{pubmed>​long:​18774427}})) (({{pubmed>​long:​18774427}})) (({{pubmed>​long:​9361174}})) (({{pubmed>​long:​15569892}})) (({{pubmed>​long:​7883407}})) (({{pubmed>​long:​9707157}})) (({{pubmed>​long:​12011605}})) (({{pubmed>​long:​11391746}})) may also suggest a single underlying cause.
  
  
 +<​blockquote>​
 +It is my opinion that early and prominent symptoms of Th1 disease are psychological which have been interpreted as anxiety, depression, insomnia, learning disabilities etc. These symptoms like physical ones are exacerbated during effective treatment of Th1 [diseases].
  
 +By understanding this, one can lessen some of the impact of those symptoms, just as one can with the physical symptoms. Not knowing why one is '​suffering'​ increases the stress of the situation which then, actually intensifies the problem. By understanding,​ one can remain more relaxed which lessens the intensity and supports recovery. Also, by accepting the temporary limitations imposed, it is again less stressful and more beneficial for recovery.
  
- +//**Greg Blaney, MD**// </​blockquote>​
- +
  
  
home/diseases/anxiety.txt · Last modified: 08.13.2019 by sallieq
© 2015, Autoimmunity Research Foundation. All Rights Reserved.