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home:diseases:cancer [04.25.2017] – [Read more] sallieqhome:diseases:cancer [11.16.2018] – [see also] sallieq
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 =====Evidence of infectious cause===== =====Evidence of infectious cause=====
  
-According to D.L. Mager, “An overwhelming body of evidence has determined that relationships among certain bacteria and cancers exist.”(({{pubmed>long:14594792}})) The growing number of examples of microbes associated with cancers include:+According to D.L. Mager, “An overwhelming body of evidence has determined that relationships among certain bacteria and cancers exist.”(({{pubmed>long:14594792}}))  The growing number of examples of microbes associated with cancers include:
  
   * **breast cancer** – Underscoring how cancer is a systemic disease, a 2006 study found that the gut bacteria //Helicobacter hepaticus// induces mammary adenocarcinoma in mice.(({{pubmed>long:16885333}}))   * **breast cancer** – Underscoring how cancer is a systemic disease, a 2006 study found that the gut bacteria //Helicobacter hepaticus// induces mammary adenocarcinoma in mice.(({{pubmed>long:16885333}}))
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-With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities.+With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities.  (({{pubmed>long:27470177}}))
  
 +==== see also MPSS Discussion ====
  
 +[[https://www.marshallprotocol.com/forum39/16259.html|Study shows mechanism for Microbiome to cause Cancer]]
 +
 +{{tag>  }}
 =====Vitamin D metabolism===== =====Vitamin D metabolism=====
  
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   * **risk of prostate cancer** – In a 2008 nested case-control study appearing in //Journal of the National Cancer Institute//, Ahn //et al.// found that patients with the lowest levels of 25-D also had the lowest risk of prostate cancer.(({{pubmed>long:18505967}}))    * **risk of prostate cancer** – In a 2008 nested case-control study appearing in //Journal of the National Cancer Institute//, Ahn //et al.// found that patients with the lowest levels of 25-D also had the lowest risk of prostate cancer.(({{pubmed>long:18505967}})) 
   * **risk of breast cancer** – In a 2011 study of nurses who were predominantly premenopausal, circulating 25-D levels were not significantly associated with breast cancer risk.   * **risk of breast cancer** – In a 2011 study of nurses who were predominantly premenopausal, circulating 25-D levels were not significantly associated with breast cancer risk.
-  * **risk of prostate cancer** – In a 2008 nested case-control study appearing in //Journal of the National Cancer Institute//, Ahn //et al.// found that patients with the lowest levels of 25-D also had the lowest risk of prostate cancer.(({{pubmed>long:18505967}}))  
   * **risk of pancreatic cancer** – Patients with the highest levels of 25-D were at greatest risk of pancreatic cancer.(({{pubmed>long:20562188}}))   * **risk of pancreatic cancer** – Patients with the highest levels of 25-D were at greatest risk of pancreatic cancer.(({{pubmed>long:20562188}}))
   * **some rarer cancers**(({{pubmed>long:20562188}})) – non-Hodgkin lymphoma or cancers of the endometrium, esophagus, stomach, kidney, ovary and pancreas   * **some rarer cancers**(({{pubmed>long:20562188}})) – non-Hodgkin lymphoma or cancers of the endometrium, esophagus, stomach, kidney, ovary and pancreas
   * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed>long:20720256}}))    * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed>long:20720256}})) 
  
-<html> + 
-<!--+ 
 +==== Are There Concerns About Over-supplementing with Vitamin D? ==== 
 + 
 +There is a common misconception that vitamin D supplementation is safe at any reasonable level, or that if some is good, more may be better. 
 + 
 +  * It is clear that vitamin D intakes and serum 25(OH)D must be very high—perhaps 200-400 ng/mL—to cause the classic toxicity of marked hypercalcemia and kidney and liver damage. 
 +  *  
 +  * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers.  
 + 
 + 
 ====1,25-dihydroxyvitamin D ==== ====1,25-dihydroxyvitamin D ====
  
 Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed>long:8989244}})) As the level of 1,25-D falls, the level of the innate immune system's ability to mount an immune response also falls, and the prognosis becomes less favorable. This seems to indicate that it might be possible to use the level of 1,25-D as one means of suggesting whether or not breast cancer treatment is effective if doctors know how to interpet the results. But, one should note that the patients in the above study had bone metastasis. Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed>long:8989244}})) As the level of 1,25-D falls, the level of the innate immune system's ability to mount an immune response also falls, and the prognosis becomes less favorable. This seems to indicate that it might be possible to use the level of 1,25-D as one means of suggesting whether or not breast cancer treatment is effective if doctors know how to interpet the results. But, one should note that the patients in the above study had bone metastasis.
---> + 
-</html>+ 
 +  
  
 ===== Single species vs. communities of microbes ===== ===== Single species vs. communities of microbes =====
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 According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>long:15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states.  According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>long:15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. 
 +
 +Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells." (({{pubmed>long:28236750}})) and  "are able to recognize and trigger cell death in tumors by detecting receptor expression abnormalities in transformed cells". (({{pubmed>long:27115170}}))  
  
 For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. //Salmonella typhi// infection has been associated with the development of gallbladder cancer; however //S. typhi// has been associated with positive outcomes for melanoma, colon and bladder cancers.(({{pubmed>long:16566840}}))  For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. //Salmonella typhi// infection has been associated with the development of gallbladder cancer; however //S. typhi// has been associated with positive outcomes for melanoma, colon and bladder cancers.(({{pubmed>long:16566840}})) 
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 In the wake of the study, physicians [[http://www.theheart.org/article/1091359.do|contended]] that it is extremely unlikely that ARBs are associated with an increased risk of cancer, with one physician saying he has data that, if added to the analysis, would wipe out any cancer signal. (See also [[http://www.medscape.com/viewarticle/724008|statement by Dr. Henry Black attesting to the safety of Benicar]]. Registration required.) Overall, they say, the media splash this paper has made could cause irreparable damage to the reputation of ARBs, which they consider vital tools in their armamentarium, and may unfortunately prompt many patients to stop taking the medicines, putting themselves at increased risk of cardiovascular and renal events. In the wake of the study, physicians [[http://www.theheart.org/article/1091359.do|contended]] that it is extremely unlikely that ARBs are associated with an increased risk of cancer, with one physician saying he has data that, if added to the analysis, would wipe out any cancer signal. (See also [[http://www.medscape.com/viewarticle/724008|statement by Dr. Henry Black attesting to the safety of Benicar]]. Registration required.) Overall, they say, the media splash this paper has made could cause irreparable damage to the reputation of ARBs, which they consider vital tools in their armamentarium, and may unfortunately prompt many patients to stop taking the medicines, putting themselves at increased risk of cardiovascular and renal events.
  
-Note also that the primary ARBs being evaluated, candesartan and telmisartan, have significant different actions than olmesartan. According to the //in silico// emulations of Dr. Marshall, they are VDR antagonists.+Note also that the primary ARBs being evaluated, candesartan and telmisartan, have significantly different actions than olmesartan. According to the //in silico// emulations of Dr. Marshall, they are VDR antagonists.
  
 =====Other treatments===== =====Other treatments=====
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 //**Polar Bear**, MarshallProtocol.com// //**Polar Bear**, MarshallProtocol.com//
 +</blockquote>
 +
 +<blockquote> I found breast cancer in 1990, had a lumpectomy and follow up mastectomy with lymph node removal, as the cancer had begun to spread there. Similarly spreading, but in different organs, killed my mother at a slightly later stage of life. She had not sought treatment until too late. I have no doubt that prompt surgery and follow up radiotherapy and tamoxifen saved my life.  At that period there were no alternatives or understanding of the microbiome.
 +
 +Interestingly, I also developed a pre-cancerous site on my skin.  This was removed in day surgery.  Something appeared years later, about the size of a 5 cent piece close to the scar of the first. I was not alarmed, but watched it for any sign of change and reported to my doctor who was prescribing my Olmesartan according to the Marshall Protocol. She duly sent me to the skin specialist, who adopted a wait and see approach. (//There would have been complications in skin surgery on that arm because of the lymphoedema developed due to air travel after the lymph node removal//). After a couple of visits he took fine detail pictures of the changing blemish. One of these days I would like to go back and ask for these pictures, as a year later, the cancer had completely gone.  
 +
 +Pathology was unable to determine whether the diagnosis was Bowen's disease or Basal Cell Cancer.  This did not surprise me as it seems common in MP patients for tests to behave differently to the general run of patients with similar conditions.
 +
 +//**Sallie Q**, MarshallProtocol.com//
 </blockquote> </blockquote>
  
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   * [[http://www.youtube.com/watch?v=s-uCeh7BGBY|Inflammation, metabolism, aging and cancer: Dangerous Liaisons]] – Distinguished Prof. Michael Karin 2010 Harvey Prize Laureate delivered this lecture at the Technion Rappaport Faculty of Medicine on March 14, 2011. Prof. Karin received the Harvey prize in recognition of his pioneering research that has led to the deciphering of the molecular mechanisms by which mammalian cells respond to inflammatory cytokines, environmental stress and various pathogens.    * [[http://www.youtube.com/watch?v=s-uCeh7BGBY|Inflammation, metabolism, aging and cancer: Dangerous Liaisons]] – Distinguished Prof. Michael Karin 2010 Harvey Prize Laureate delivered this lecture at the Technion Rappaport Faculty of Medicine on March 14, 2011. Prof. Karin received the Harvey prize in recognition of his pioneering research that has led to the deciphering of the molecular mechanisms by which mammalian cells respond to inflammatory cytokines, environmental stress and various pathogens. 
 +  * [[http://www.oatext.com/pdf/ICST-4-231.pdf|2017 review of RAS system observations suggesting cancer stem cells may be a novel therapeutic target]]
   * [[http://www.reuters.com/article/2012/01/07/us-argentina-fernandez-idUSTRE8060CB20120107|Argentina's Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.   * [[http://www.reuters.com/article/2012/01/07/us-argentina-fernandez-idUSTRE8060CB20120107|Argentina's Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.
   * [[https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]   * [[https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]
 +  * [[https://www.amjmed.com/article/S0002-9343(15)00509-4/pdf|Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference]]
 +  * [[http://www.foodsmatter.com/es/health_risks/articles/goldsworthy-biological-effects-04-12.pdf|biological effects]]
 +  * [[http://bioinitiative.org/report/wp-content/uploads/pdfs/sec01_2012_summary_for_public.pdf|Bioinitiative Report]]
 +
 +"The most serious  health  endpoints  that  have  been  reported  to  be  associated  with  extremely  low  frequency  (ELF)  and/or 
 +radiofrequency  radiation  (RFR)  include  childhood  and  adult  leukemia,  childhood  and  adult  brain  tumors,  and 
 +increased  risk  of  the  neurodegenerative  diseases,  Alzheimer’s  and  amyotrophic  lateral  sclerosis  (ALS).  In 
 +addition, there are reports of increased risk of breast cancer in both men and women, genotoxic effects (DNA 
 +damage,  chromatin  condensation,  micronucleation,  impaired  repair  of  DNA  damage  in  human  stem  cells), 
 +pathological  leakage  of  the blood–brain barrier, altered immune function including increased allergic and 
 +inflammatory responses, miscarriage and some cardiovascular effects."
  
  
home/diseases/cancer.txt · Last modified: 09.14.2022 by 127.0.0.1
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