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home:diseases:cancer [06.12.2017] – [Read more] sallieq | home:diseases:cancer [09.06.2018] – [1,25-dihydroxyvitamin D] sallieq | ||
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* **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed> | * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed> | ||
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- | <!-- | + | |
+ | ==== Are There Concerns About Over-supplementing with Vitamin D? ==== | ||
+ | |||
+ | There is a common misconception that vitamin D supplementation is safe at any reasonable level, or that if some is good, more may be better. | ||
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+ | * It is clear that vitamin D intakes and serum 25(OH)D must be very high—perhaps 200-400 ng/mL—to cause the classic toxicity of marked hypercalcemia and kidney and liver damage. | ||
+ | * | ||
+ | * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers. | ||
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+ | from | ||
+ | [[https:// | ||
====1, | ====1, | ||
Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed> | Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed> | ||
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===== Single species vs. communities of microbes ===== | ===== Single species vs. communities of microbes ===== | ||
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According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed> | According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed> | ||
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+ | Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells." | ||
For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. // | For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. // | ||
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In the wake of the study, physicians [[http:// | In the wake of the study, physicians [[http:// | ||
- | Note also that the primary ARBs being evaluated, candesartan and telmisartan, | + | Note also that the primary ARBs being evaluated, candesartan and telmisartan, |
=====Other treatments===== | =====Other treatments===== | ||
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* [[http:// | * [[http:// | ||
+ | * [[http:// | ||
* [[http:// | * [[http:// | ||
* [[https:// | * [[https:// | ||
* [[http:// | * [[http:// | ||
+ | * [[http:// | ||
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+ | "The most serious | ||
+ | radiofrequency | ||
+ | increased | ||
+ | addition, there are reports of increased risk of breast cancer in both men and women, genotoxic effects (DNA | ||
+ | damage, | ||
+ | pathological | ||
+ | inflammatory responses, miscarriage and some cardiovascular effects." | ||