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home:diseases:cancer [09.06.2018] – [1,25-dihydroxyvitamin D] sallieq | home:diseases:cancer [01.26.2019] – [Recent research] sallieq | ||
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With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities. | With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities. | ||
+ | ==== see also MPSS Discussion ==== | ||
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=====Vitamin D metabolism===== | =====Vitamin D metabolism===== | ||
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* However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers. | * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers. | ||
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Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed> | Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed> | ||
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During a normal response to infection, inflammation is created as a means for the host to combat invading pathogens. Inflammation is first initiated by the recruitment of phagocytes to the site of infection. The phagocytes recruited to the site of infection also secrete proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), | During a normal response to infection, inflammation is created as a means for the host to combat invading pathogens. Inflammation is first initiated by the recruitment of phagocytes to the site of infection. The phagocytes recruited to the site of infection also secrete proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), | ||
- | The result is the release of reactive oxygen and nitrogen oxide species (ROS and RNOS) to kill potential pathogens. The free radicals and secondary products derived from them, such as secondary amines, HNO2, N2O3, and peroxynitrite, | + | The result is the release of reactive oxygen and nitrogen oxide species (ROS and RNOS) to kill potential pathogens. The free radicals and secondary products derived from them, such as secondary amines, HNO2, N2O3, and peroxynitrite, |
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+ | Advanced stage follicular lymphoma (FL) is incurable by conventional therapies.(({{pubmed> | ||
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{{section>: | {{section>: | ||
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Note also that the primary ARBs being evaluated, candesartan and telmisartan, | Note also that the primary ARBs being evaluated, candesartan and telmisartan, | ||
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+ | ==== Research ==== | ||
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+ | CONCLUSION: | ||
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=====Other treatments===== | =====Other treatments===== | ||
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+ | ===== Recent research ===== | ||
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+ | "It turns out macrophages need to be primed before they can go to work, which explains why solid tumors may resist treatment with CD47 inhibitors alone," | ||
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+ | (({{pubmed> | ||
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=====Read more===== | =====Read more===== | ||
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* [[http:// | * [[http:// | ||
* [[https:// | * [[https:// | ||
+ | * [[https:// | ||
* [[http:// | * [[http:// | ||
* [[http:// | * [[http:// |