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home:diseases:cancer [03.01.2019] – [1,25-dihydroxyvitamin D] sallieq | home:diseases:cancer [04.19.2019] – [Vitamin D] sallieq | ||
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With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities. | With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities. | ||
- | ==== see also MPSS Discussion | + | ==== see also M P Study Site ==== |
[[https:// | [[https:// | ||
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- | ==== Are There Concerns About Supplementing with Vitamin | + | ==== Are There Concerns About V.D Supplement |
There is a common misconception that vitamin D supplementation is safe at any reasonable level, or that if some is good, more may be better. | There is a common misconception that vitamin D supplementation is safe at any reasonable level, or that if some is good, more may be better. | ||
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Women with hereditary breast cancer predispositions should avoid using their smartphones, | Women with hereditary breast cancer predispositions should avoid using their smartphones, | ||
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+ | Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100,000 population. These tumors are typically associated with a dismal prognosis and poor quality of life. Only radiation exposure and certain genetic syndromes are well-defined risk factors for malignant glioma. | ||
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+ | Several researchers have highlighted a possible link between glioma and human cytomegalovirus (HCMV). | ||
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Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers' | Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers' | ||
- | A number of types of chronic infection have been observed to be associated with cancers in some studies, but without an identified specific bacterial pathogen. Examples are chronic ulcers and osteomyelitis | + | A number of types of chronic infection have been observed to be associated with cancers in some studies, but without an identified specific bacterial pathogen. Examples are chronic ulcers and osteomylitis, |
The Marshall Pathogenesis is at complete odds with Koch's postulates, suggesting that it is not one species but entire communities of microbes that are responsible for many cancers. The process by which a person accumulates microbes responsible for disease is known as “successive infection.” In successive infection, an infectious cascade of pathogens progressively slow the immune response and allow for subsequent infections to proliferate, | The Marshall Pathogenesis is at complete odds with Koch's postulates, suggesting that it is not one species but entire communities of microbes that are responsible for many cancers. The process by which a person accumulates microbes responsible for disease is known as “successive infection.” In successive infection, an infectious cascade of pathogens progressively slow the immune response and allow for subsequent infections to proliferate, | ||
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- | =====Marshall Protocol as a treatment for cancer? | + | ===== Marshall Protocol as a treatment for cancer? ===== |
The MP uses olmesartan to activate the VDR, a nuclear receptor which is downregulated in cancer. While the MP appears to be a sensible preventive, it is not suitable for treating active metastasis. | The MP uses olmesartan to activate the VDR, a nuclear receptor which is downregulated in cancer. While the MP appears to be a sensible preventive, it is not suitable for treating active metastasis. | ||
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+ | ==== Research ==== | ||
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+ | This result provides a new idea on the anti-tumor mechanism of olmesartan, which may be used as a novel therapeutic target of cervical cancer. | ||
====Safety of olmesartan==== | ====Safety of olmesartan==== | ||
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Note also that the primary ARBs being evaluated, candesartan and telmisartan, | Note also that the primary ARBs being evaluated, candesartan and telmisartan, | ||
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=====Other treatments===== | =====Other treatments===== | ||
- | ====Vitamin D======== | ||
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- | {{section> | + | [[http:// |
====Chemotherapy and radiation==== | ====Chemotherapy and radiation==== | ||
- | Chemotherapy is aggressively immunosuppressive, | + | Chemotherapy is aggressively immunosuppressive, |
+ | ==== Treatment for acute active Cancers==== | ||
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+ | ==== Toll-like receptor 9 (TLR9) agonists ==== | ||
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+ | The activity and safety of these novel anticancer agents are being explored in a wide range of tumor types as part of a variety of therapeutic strategies with the goal of harnessing the immune response to fight cancer. | ||
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+ | Activation of Toll-Like Receptor 9 by DNA from Different Bacterial Species | ||
====Vaccines==== | ====Vaccines==== | ||
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//**Gene**, MarshallProtocol.com//</ | //**Gene**, MarshallProtocol.com//</ | ||
+ | ==== Vitamin D==== | ||
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+ | === Vitamin E === | ||
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+ | Vitamin E supplementation and the risk of heart failure in women. | ||
+ | (({{pubmed> | ||
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+ | Supplementation with vitamin E did not result in any significant improvements in prognostic or functional indexes of heart failure or in the quality of life of patients with advanced heart failure.(({{pubmed> | ||
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+ | Canolol was found to counteract the fibrotic effects of vitamin E + CoQ10 on cardiac fibrosis in the context of a high-fat diet enriched with RSO. This effect occurred through a restoration of cardiac Ag2R-1b mRNA expression and decreased ischemia.(({{pubmed> | ||
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Researchers trialling gene therapies against cancer have been unsuccessful to date. Such initiatives have yet to take into account the types of intracellular microbes implicated by the Marshall Pathogenesis. One, a Duke University program, to tailor cancer treatments to certain cancers [[http:// | Researchers trialling gene therapies against cancer have been unsuccessful to date. Such initiatives have yet to take into account the types of intracellular microbes implicated by the Marshall Pathogenesis. One, a Duke University program, to tailor cancer treatments to certain cancers [[http:// | ||
- | ==== Toll-like receptor 9 (TLR9) agonists ==== | ||
- | The activity and safety of these novel anticancer agents are being explored in a wide range of tumor types as part of a variety of therapeutic strategies with the goal of harnessing the immune response to fight cancer. | ||
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- | Activation of Toll-Like Receptor 9 by DNA from Different Bacterial Species | ||
=====Screening and diagnosis===== | =====Screening and diagnosis===== | ||
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+ | I found breast cancer in 1990, had a lumpectomy and follow up mastectomy with lymph node removal, as the cancer had begun to spread there. Similarly spreading, but in different organs, killed my mother at a slightly later stage of life. She had not sought treatment until too late. I have no doubt that prompt surgery and follow up radiotherapy and tamoxifen saved my life. At that period there were no alternatives or understanding of the microbiome. | ||
Interestingly, | Interestingly, | ||
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Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer. (({{pubmed> | Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer. (({{pubmed> | ||
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+ | Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity and apoptosis induction against tumour cells. So ARBs and NF-kappaB pathway inhibitors could be considered as anticancer drugs in future. | ||
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+ | In this large population-based gastro-oesophageal cancer cohort, we found moderately reduced cancer-specific mortality among ARB users. However, confirmation in further independent epidemiological studies with sufficient staging information is required. | ||
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+ | miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan. | ||
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+ | Therapeutic potentials of SCFA receptors [section 7 in | ||
+ | Recent progress in understanding the role of GPR41, GPR43 and GPR109A in health and disease demonstrate that these receptors do not just regulate inflammation and cancer in intestine, but also influence other gastrointestinal functions, allergies, adipogenesis, | ||
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Vitamin D and immune cells stimulate bone marrow disease (({{pubmed> | Vitamin D and immune cells stimulate bone marrow disease (({{pubmed> | ||
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* [[https:// | * [[https:// | ||
* [[https:// | * [[https:// | ||
- | * [[http:// | + | * [[http:// |
* [[http:// | * [[http:// | ||