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home:diseases:cancer [05.16.2019] – [Other Immune Suppressants] sallieqhome:diseases:cancer [06.29.2019] – sallieq
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-Women with hereditary breast cancer predispositions should put their smartphones, tablets, and laptops into air-plane mode at all times when not in use.   (({{pubmed>long:    29456806}}))+Women with hereditary cancer predispositions should put their smartphones, tablets, and laptops into air-plane mode at all times when not in use.   (({{pubmed>long:    29456806}}))
  
 Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100,000 population. These tumors are typically associated with a dismal prognosis and poor quality of life. Only radiation exposure and certain genetic syndromes are well-defined risk factors for malignant glioma.   (({{pubmed>long:    24193082}}))  Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100,000 population. These tumors are typically associated with a dismal prognosis and poor quality of life. Only radiation exposure and certain genetic syndromes are well-defined risk factors for malignant glioma.   (({{pubmed>long:    24193082}})) 
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 +===== Microbial involvement =====
  
  
-===== Single species vs. communities of microbes =====+==== Single species vs. communities of microbes ====
  
 Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers' satisfaction.(({{pubmed>long:20930075}})) Identifying the full range of microbes which cause cancer, however, has been more challenging. To date, there have been a handful of cases that fulfill Koch's postulates (e.g., //H. pylori// and gastric cancer) where a single microbe is known to cause a single type of cancer. Consistent with Koch, researchers have tended to work in this vein, for example, looking at the 500+ species that inhabit the colon in the hopes of pinpointing the one and only bacterial species responsible for colorectal cancer.(({{pubmed>long:20930075}})) Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers' satisfaction.(({{pubmed>long:20930075}})) Identifying the full range of microbes which cause cancer, however, has been more challenging. To date, there have been a handful of cases that fulfill Koch's postulates (e.g., //H. pylori// and gastric cancer) where a single microbe is known to cause a single type of cancer. Consistent with Koch, researchers have tended to work in this vein, for example, looking at the 500+ species that inhabit the colon in the hopes of pinpointing the one and only bacterial species responsible for colorectal cancer.(({{pubmed>long:20930075}}))
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-===== Slow-growing microbes elicit inflammation =====+==== Slow-growing microbes elicit inflammation ====
  
 <blockquote>In almost all examples of bacterial inflammation and human cancer, the implicated bacteria reside in the host for many years and create an environment of persistent inflammation. Specific bacteria that have been shown to cause chronic inflammation and an increased risk of cancer include //Helicobacter pylori// (gastric adenocarcinoma) and //Salmonella enterica serovar Typhimurium// or //Paratyphi// (biliary cancer). <blockquote>In almost all examples of bacterial inflammation and human cancer, the implicated bacteria reside in the host for many years and create an environment of persistent inflammation. Specific bacteria that have been shown to cause chronic inflammation and an increased risk of cancer include //Helicobacter pylori// (gastric adenocarcinoma) and //Salmonella enterica serovar Typhimurium// or //Paratyphi// (biliary cancer).
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-===== Inflammation induces cancer =====+==== Inflammation induces cancer ====
  
 According to Chang,(({{pubmed>long:20930075}})) Virchow first described the irritation hypothesis of carcinogenesis in the 19th century concluding that chronic irritation stimulated the cancer cells to grow. The inflammatory process is characterized by damage caused by the host's immune response to the infection rather than by the infecting organism itself. Over 100 years since Virchow's discoveries, the “chronic irritation hypothesis” remains a widely supported mechanism for carcinogenesis by infectious agents. Today the relationship between inflammation, innate immunity and cancer is widely accepted.(({{pubmed>long:21088404}}))  According to Chang,(({{pubmed>long:20930075}})) Virchow first described the irritation hypothesis of carcinogenesis in the 19th century concluding that chronic irritation stimulated the cancer cells to grow. The inflammatory process is characterized by damage caused by the host's immune response to the infection rather than by the infecting organism itself. Over 100 years since Virchow's discoveries, the “chronic irritation hypothesis” remains a widely supported mechanism for carcinogenesis by infectious agents. Today the relationship between inflammation, innate immunity and cancer is widely accepted.(({{pubmed>long:21088404}})) 
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-===== Microbial interaction and disease =====+==== Microbial interaction and disease ====
  
 According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>long:15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states.  According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>long:15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. 
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-===== Metastatic communities parallel biofilm =====+==== Metastatic communities parallel biofilm ====
  
 Some have suggested provocatively that communities of metastatic cancerous cells closely resemble communities of microbes known as biofilm. Some have suggested provocatively that communities of metastatic cancerous cells closely resemble communities of microbes known as biofilm.
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- +==== Tobacco ====
-====Tobacco====+
 {{section>:home:special:smoking#smoking_tobacco&noheader&firstseconly}} {{section>:home:special:smoking#smoking_tobacco&noheader&firstseconly}}
 +
 +
 +==== Stress derived from interaction of particular personalities ====
 +
 +in particular [[https://duckduckgo.com/?q=energy+vampires&t=ffnt&atb=v117-1&ia=about|the empathic personality and the 'energy vampire']]
 +
 +from https://mpkb.org/home/social/talking#dealing_with_antagonism
 +
 +<blockquote>Sadly, some people in your life may not want you to get well. For example, sometimes a partner or close friend can not tolerate change. Consciously or unconsciously they may undermine your efforts. It will be up to you to quietly persist, knowing that your recovery can only lead to a better outcome for both of you.
 +
 +In an extreme case, there may be someone who is literally toxic, even socio-pathic. “Learn to value yourself, Learn to say No!” and if necessary, Remove yourself from the influence of any such person.</blockquote> 
  
  
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 In this large population-based gastro-oesophageal cancer cohort, we found moderately reduced cancer-specific mortality among ARB users. However, confirmation in further independent epidemiological studies with sufficient staging information is required.  (({{pubmed>long:29105106}})) In this large population-based gastro-oesophageal cancer cohort, we found moderately reduced cancer-specific mortality among ARB users. However, confirmation in further independent epidemiological studies with sufficient staging information is required.  (({{pubmed>long:29105106}}))
  
-miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan.  (({{pubmed>long:    28304186}}))+miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan.  (({{pubmed>long:28304186}}))
  
 Therapeutic potentials of SCFA receptors [section 7 in   (({{pubmed>long:27113407}})) ] Therapeutic potentials of SCFA receptors [section 7 in   (({{pubmed>long:27113407}})) ]
 Recent progress in understanding the role of GPR41, GPR43 and GPR109A in health and disease demonstrate that these receptors do not just regulate inflammation and cancer in intestine, but also influence other gastrointestinal functions, allergies, adipogenesis, central nervous system and cardiovascular health. Recent progress in understanding the role of GPR41, GPR43 and GPR109A in health and disease demonstrate that these receptors do not just regulate inflammation and cancer in intestine, but also influence other gastrointestinal functions, allergies, adipogenesis, central nervous system and cardiovascular health.
  
 + review current evidence on the role of the human microbiota in four cancer types (colorectal cancer, head and neck cancer, pancreatic cancer, and lung cancer) proposed as affected by both the oral and gut microbiota (({{pubmed>long:28822617}}))
 +
 + results suggest that the six lactic acid bacteria mixture from kefir has strong effects on natural immunity and tumor cell cytotoxicity(({{pubmed>long:29584690}}))
 +
 + Using metabolomics, we investigated the metabolic influence that microbial biofilms have on colon tissues and the related occurrence of cancer.(({{pubmed>long:25959674}}))
  
  
home/diseases/cancer.txt · Last modified: 09.14.2022 by 127.0.0.1
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