This shows you the differences between two versions of the page.
Both sides previous revisionPrevious revisionNext revision | Previous revisionNext revisionBoth sides next revision | ||
home:diseases:cancer [08.29.2017] – [Safety of olmesartan] sallieq | home:diseases:cancer [12.01.2018] – [Inflammation induces cancer] sallieq | ||
---|---|---|---|
Line 21: | Line 21: | ||
With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities. | With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities. | ||
+ | ==== see also MPSS Discussion ==== | ||
+ | [[https:// | ||
+ | |||
+ | {{tag> | ||
=====Vitamin D metabolism===== | =====Vitamin D metabolism===== | ||
Line 51: | Line 55: | ||
* **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed> | * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed> | ||
- | < | + | |
- | <!-- | + | |
+ | ==== Are There Concerns About Over-supplementing with Vitamin D? ==== | ||
+ | |||
+ | There is a common misconception that vitamin D supplementation is safe at any reasonable level, or that if some is good, more may be better. | ||
+ | |||
+ | * It is clear that vitamin D intakes and serum 25(OH)D must be very high—perhaps 200-400 ng/mL—to cause the classic toxicity of marked hypercalcemia and kidney and liver damage. | ||
+ | * | ||
+ | * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers. | ||
+ | |||
+ | |||
====1, | ====1, | ||
Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed> | Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed> | ||
- | --> | + | |
- | </ | + | |
+ | |||
===== Single species vs. communities of microbes ===== | ===== Single species vs. communities of microbes ===== | ||
Line 90: | Line 106: | ||
During a normal response to infection, inflammation is created as a means for the host to combat invading pathogens. Inflammation is first initiated by the recruitment of phagocytes to the site of infection. The phagocytes recruited to the site of infection also secrete proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), | During a normal response to infection, inflammation is created as a means for the host to combat invading pathogens. Inflammation is first initiated by the recruitment of phagocytes to the site of infection. The phagocytes recruited to the site of infection also secrete proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), | ||
- | The result is the release of reactive oxygen and nitrogen oxide species (ROS and RNOS) to kill potential pathogens. The free radicals and secondary products derived from them, such as secondary amines, HNO2, N2O3, and peroxynitrite, | + | The result is the release of reactive oxygen and nitrogen oxide species (ROS and RNOS) to kill potential pathogens. The free radicals and secondary products derived from them, such as secondary amines, HNO2, N2O3, and peroxynitrite, |
+ | |||
+ | < | ||
+ | Advanced stage follicular lymphoma (FL) is incurable by conventional therapies.(({{pubmed> | ||
Line 96: | Line 115: | ||
According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed> | According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed> | ||
+ | |||
+ | Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells." | ||
For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. // | For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. // | ||
Line 268: | Line 289: | ||
* [[http:// | * [[http:// | ||
+ | * [[http:// | ||
* [[http:// | * [[http:// | ||
* [[https:// | * [[https:// | ||
+ | * [[https:// | ||
* [[http:// | * [[http:// | ||
+ | * [[http:// | ||
+ | |||
+ | "The most serious | ||
+ | radiofrequency | ||
+ | increased | ||
+ | addition, there are reports of increased risk of breast cancer in both men and women, genotoxic effects (DNA | ||
+ | damage, | ||
+ | pathological | ||
+ | inflammatory responses, miscarriage and some cardiovascular effects." | ||