You are here: Welcome to the MPKB » Welcome to the MPKB » Diseases » Cancer
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
Next revisionBoth sides next revision
home:diseases:cancer [06.12.2018] – [Microbial interaction and disease] sallieqhome:diseases:cancer [09.06.2018] – [25-hydroxyvitamin D] sallieq
Line 51: Line 51:
   * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed>long:20720256}}))    * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed>long:20720256}})) 
  
-<html> + 
-<!--+ 
 +==== Are There Concerns About Over-supplementing with Vitamin D? ==== 
 + 
 +There is a common misconception that vitamin D supplementation is safe at any reasonable level, or that if some is good, more may be better. 
 + 
 +  * It is clear that vitamin D intakes and serum 25(OH)D must be very high—perhaps 200-400 ng/mL—to cause the classic toxicity of marked hypercalcemia and kidney and liver damage. 
 +  *  
 +  * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers.  
 + 
 +from  
 +[[https://www.amjmed.com/article/S0002-9343(15)00509-4/pdf|Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference]] 
 ====1,25-dihydroxyvitamin D ==== ====1,25-dihydroxyvitamin D ====
  
Line 58: Line 69:
 --> -->
 </html> </html>
 +
 + 
 +
  
 ===== Single species vs. communities of microbes ===== ===== Single species vs. communities of microbes =====
Line 97: Line 111:
 According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>long:15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states.  According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>long:15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. 
  
-Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells." (({{pubmed>long:28236750}})) and  "are able to recognize and trigger cell death in tumors by detecting receptor expression abnormalities in transformed cells" (({{pubmed>long:27115170}}))  +Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells." (({{pubmed>long:28236750}})) and  "are able to recognize and trigger cell death in tumors by detecting receptor expression abnormalities in transformed cells". (({{pubmed>long:27115170}}))  
  
 For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. //Salmonella typhi// infection has been associated with the development of gallbladder cancer; however //S. typhi// has been associated with positive outcomes for melanoma, colon and bladder cancers.(({{pubmed>long:16566840}}))  For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. //Salmonella typhi// infection has been associated with the development of gallbladder cancer; however //S. typhi// has been associated with positive outcomes for melanoma, colon and bladder cancers.(({{pubmed>long:16566840}})) 
home/diseases/cancer.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.