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home:diseases:cancer [09.06.2018] – [25-hydroxyvitamin D] sallieqhome:diseases:cancer [01.01.2019] – [1,25-dihydroxyvitamin D] sallieq
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 With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities.  (({{pubmed>long:27470177}})) With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities.  (({{pubmed>long:27470177}}))
  
 +==== see also MPSS Discussion ====
  
 +[[https://www.marshallprotocol.com/forum39/16259.html|Study shows mechanism for Microbiome to cause Cancer]]
 +
 +{{tag>  }}
 =====Vitamin D metabolism===== =====Vitamin D metabolism=====
  
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   * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers.    * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers. 
  
-from  +
-[[https://www.amjmed.com/article/S0002-9343(15)00509-4/pdf|Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference]]+
  
 ====1,25-dihydroxyvitamin D ==== ====1,25-dihydroxyvitamin D ====
  
 Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed>long:8989244}})) As the level of 1,25-D falls, the level of the innate immune system's ability to mount an immune response also falls, and the prognosis becomes less favorable. This seems to indicate that it might be possible to use the level of 1,25-D as one means of suggesting whether or not breast cancer treatment is effective if doctors know how to interpet the results. But, one should note that the patients in the above study had bone metastasis. Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed>long:8989244}})) As the level of 1,25-D falls, the level of the innate immune system's ability to mount an immune response also falls, and the prognosis becomes less favorable. This seems to indicate that it might be possible to use the level of 1,25-D as one means of suggesting whether or not breast cancer treatment is effective if doctors know how to interpet the results. But, one should note that the patients in the above study had bone metastasis.
---> + 
-</html>+[[https://autoimmunityresearch.org/hormones.pdf|Hormonal changes result from change in 1,25 dihydroxyvitamin-D]] 
 + 
  
    
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 During a normal response to infection, inflammation is created as a means for the host to combat invading pathogens. Inflammation is first initiated by the recruitment of phagocytes to the site of infection. The phagocytes recruited to the site of infection also secrete proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), and chemokines that attract more phagocytes and other cells of the immune system to the site of infection to amplify the inflammatory response. These cells respond through physiological processes mediated by the cellular enzymes NADPH oxidase, superoxide dismutase (SOD), myeloperoxidase, and nitric oxide synthase (NOS).  During a normal response to infection, inflammation is created as a means for the host to combat invading pathogens. Inflammation is first initiated by the recruitment of phagocytes to the site of infection. The phagocytes recruited to the site of infection also secrete proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), and chemokines that attract more phagocytes and other cells of the immune system to the site of infection to amplify the inflammatory response. These cells respond through physiological processes mediated by the cellular enzymes NADPH oxidase, superoxide dismutase (SOD), myeloperoxidase, and nitric oxide synthase (NOS). 
  
-The result is the release of reactive oxygen and nitrogen oxide species (ROS and RNOS) to kill potential pathogens. The free radicals and secondary products derived from them, such as secondary amines, HNO2, N2O3, and peroxynitrite, may damage DNA, proteins, and cell membranes and indirectly induce cell repair. Areas of tissue injury and inflammation trigger regenerative cell division from tissue and marrow-derived stem cells. Increased cell division may lead to point mutations, deletions, or translocations as damaged DNA escapes the repair system; the aberrant DNA is then propagated by subsequent cell division. This can result in disordered cell differentiation and, ultimately, oncogenesis. Hence, chronic inflammation, caused by microbes, instigates a cycle of cell damage, repair, and compensatory proliferation that promotes the development of cancer cells.(({{pubmed>long:21088404}}))+The result is the release of reactive oxygen and nitrogen oxide species (ROS and RNOS) to kill potential pathogens. The free radicals and secondary products derived from them, such as secondary amines, HNO2, N2O3, and peroxynitrite, may damage DNA, proteins, and cell membranes and indirectly induce cell repair. Areas of tissue injury and inflammation trigger regenerative cell division from tissue and marrow-derived stem cells. Increased cell division may lead to point mutations, deletions, or translocations as damaged DNA escapes the repair system; the aberrant DNA is then propagated by subsequent cell division. This can result in disordered cell differentiation and, ultimately, oncogenesis. Hence, chronic inflammation, caused by microbes, instigates a cycle of cell damage, repair, and compensatory proliferation that promotes the development of cancer cells. 
 + 
 +<blockquote> 
 +Advanced stage follicular lymphoma (FL) is incurable by conventional therapies.(({{pubmed>long:    25293773}}))</blockquote>
  
  
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 {{section>:home:alternate:genetic_predisposition#cancer&noheader&firstseconly}} {{section>:home:alternate:genetic_predisposition#cancer&noheader&firstseconly}}
 +
 + <blockquote>These findings suggest that pro-tumorigenic entotic engulfment activity is associated with mutant p53 expression, and the two combined are a key factor in genomic instability (({{pubmed>long:30076358}}))</blockquote> 
  
  
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 Note also that the primary ARBs being evaluated, candesartan and telmisartan, have significantly different actions than olmesartan. According to the //in silico// emulations of Dr. Marshall, they are VDR antagonists. Note also that the primary ARBs being evaluated, candesartan and telmisartan, have significantly different actions than olmesartan. According to the //in silico// emulations of Dr. Marshall, they are VDR antagonists.
 +
 +==== Research ====
 +
 +<blockquote>analyses found no evidence that cancer risk increased with increasing duration of ARB exposure (RR increase per year=0.99)
 +
 +CONCLUSION:  In this large nationwide cohort, use of ARBs was not significantly associated with increased risk of incident cancer overall or of lung cancer.  (({{pubmed>long:21482967}}))</blockquote>
 +
 +
 +    
 +
  
 =====Other treatments===== =====Other treatments=====
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   * [[http://www.reuters.com/article/2012/01/07/us-argentina-fernandez-idUSTRE8060CB20120107|Argentina's Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.   * [[http://www.reuters.com/article/2012/01/07/us-argentina-fernandez-idUSTRE8060CB20120107|Argentina's Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.
   * [[https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]   * [[https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]
 +  * [[https://www.amjmed.com/article/S0002-9343(15)00509-4/pdf|Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference]]
   * [[http://www.foodsmatter.com/es/health_risks/articles/goldsworthy-biological-effects-04-12.pdf|biological effects]]   * [[http://www.foodsmatter.com/es/health_risks/articles/goldsworthy-biological-effects-04-12.pdf|biological effects]]
   * [[http://bioinitiative.org/report/wp-content/uploads/pdfs/sec01_2012_summary_for_public.pdf|Bioinitiative Report]]   * [[http://bioinitiative.org/report/wp-content/uploads/pdfs/sec01_2012_summary_for_public.pdf|Bioinitiative Report]]
home/diseases/cancer.txt · Last modified: 09.14.2022 by 127.0.0.1
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