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home:diseases:celiac [07.19.2019] – [Celiac disease] sallieqhome:diseases:celiac [09.14.2022] (current) – external edit 127.0.0.1
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-People with celiac disease react to gluten, which is found in wheat, rye, spelt and barley. Villus atrophy in the small intestine is one of the most significant findings in celiac disease, rendering the patient with a poor absorptive capacity.  The vast majority of celiac patients produce antibodies to tissue transglutaminase and have either the gene variant HLA-DQ-2 or HLA-DQ-8. However, these gene variants are much more common than the occurence of celiac disease. Thus, there must be additional factors that can explain why celiac disease develops. (({{pubmed>long:18667914}}))+People with celiac disease react to gluten, which is found in wheat, rye, spelt and barley. Villus atrophy in the small intestine is one of the most significant findings in celiac disease, rendering the patient with a poor absorptive capacity.  The vast majority of celiac patients produce antibodies to tissue transglutaminase and have either the gene variant HLA-DQ-2 or HLA-DQ-8. However, these gene variants are much more common than the occurence of celiac disease. Thus, there must be additional factors that can explain why celiac disease develops. (({{pmid>long:18667914}}))
 ===== Epidemiology ===== ===== Epidemiology =====
  
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-CONCLUSIONS: The mode of delivery and associated alterations in the development of the enteric homeostasis during the neonatal period might influence the incidence of celiac disease.  (({{pubmed>long:20478942}}))+CONCLUSIONS: The mode of delivery and associated alterations in the development of the enteric homeostasis during the neonatal period might influence the incidence of celiac disease.  (({{pmid>long:20478942}}))
 </blockquote> </blockquote>
 +
 +The emerging data on viral and bacterial microbe-host interactions and their alterations in celiac disease provides a plausible mechanism linking environmental risk and disease development. (({{pmid>long:30519552}}))
  
  
 ===== Celiac and D metabolite levels ===== ===== Celiac and D metabolite levels =====
  
-Some patients with celiac disease have low/normal 25D but elevated 1,25D apparently related to celiac.  (({{pubmed>long:8186825}}))  +Some patients with celiac disease have low/normal 25D but elevated 1,25D apparently related to celiac.  (({{pmid>long:8186825}}))  
  
-Our patient had hypocalcemia caused by celiac disease and values for serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D that were normal and elevated, respectively. Correction was demonstrated after dietary gluten withdrawal. (({{pubmed>long:15310538}}))+Our patient had hypocalcemia caused by celiac disease and values for serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D that were normal and elevated, respectively. Correction was demonstrated after dietary gluten withdrawal. (({{pmid>long:15310538}}))
  
-Calcium and vitamin D supplement intake may increase arterial stiffness in systemic lupus erythematosus patients. (({{pubmed>long:30628012}})) +Calcium and vitamin D supplement intake may increase arterial stiffness in systemic lupus erythematosus patients. (({{pmid>long:30628012}})) 
  
- (({{pubmed>long:000}})) + (({{pmid>long:000}})) 
  
 ===== Evidence of infectious cause ===== ===== Evidence of infectious cause =====
  
-<blockquote>"The finding of rod-shaped bacteria attached to the small intestinal epithelium of some untreated and treated celiac-disease patients, but not to the epithelium of healthy controls, ignites the notion that bacteria may be involved in the pathogenesis of celiac disease." Am J Gastroenterol. 2004 May;99(5):905-6. A role for bacteria in celiac disease? Sollid LM, Gray GM  (({{pubmed>long:15128358}}))+<blockquote>"The finding of rod-shaped bacteria attached to the small intestinal epithelium of some untreated and treated celiac-disease patients, but not to the epithelium of healthy controls, ignites the notion that bacteria may be involved in the pathogenesis of celiac disease." Am J Gastroenterol. 2004 May;99(5):905-6. A role for bacteria in celiac disease? Sollid LM, Gray GM  (({{pmid>long:15128358}}))
 </blockquote> </blockquote>
  
 <blockquote>"As presence of Campylobacter jejuni in other diseases with antigangliosides antibody formation has been established, we propose the possible role of Campylobacter jejuni in development of CD in association with other genetic and environmental factors by the mechanism that molecular mimicry of gangliosides-like epitopes common to both lipo-polysacharide coats of certain strains of Campylobacter jejuni and gangliosides in cell structure of gastrointestinal mucosa may cause an autoimmune response and consequently lead to atrophy and degeneration of mucosa possibly by apoptosis." World J Gastroenterol. 2007 Sep 21;13(35):4784-5. Can Campylobacter jejuni play a role in development of celiac disease?  <blockquote>"As presence of Campylobacter jejuni in other diseases with antigangliosides antibody formation has been established, we propose the possible role of Campylobacter jejuni in development of CD in association with other genetic and environmental factors by the mechanism that molecular mimicry of gangliosides-like epitopes common to both lipo-polysacharide coats of certain strains of Campylobacter jejuni and gangliosides in cell structure of gastrointestinal mucosa may cause an autoimmune response and consequently lead to atrophy and degeneration of mucosa possibly by apoptosis." World J Gastroenterol. 2007 Sep 21;13(35):4784-5. Can Campylobacter jejuni play a role in development of celiac disease? 
-Sabayan B, Foroughinia F, Imanieh MH  (({{pubmed>long:17729402}})) </blockquote> +Sabayan B, Foroughinia F, Imanieh MH  (({{pmid>long:17729402}})) </blockquote> 
  
-Specific duodenal and faecal bacterial groups are associated with paediatric celiac disease.(({{pubmed>long:18996905}}))+Specific duodenal and faecal bacterial groups are associated with paediatric celiac disease.(({{pmid>long:18996905}}))
  
-Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation.(({{pubmed>long:18979579}}))+Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation.(({{pmid>long:18979579}}))
  
-Autoantibodies involved in celiac disease are not specific, as infection may increase levels of anti-transglutaminase antibodies. These antibodies are not detectable once the infection is gone.(({{pubmed>long:19912255}}))+Autoantibodies involved in celiac disease are not specific, as infection may increase levels of anti-transglutaminase antibodies. These antibodies are not detectable once the infection is gone.(({{pmid>long:19912255}}))
  
 ==== recent research ==== ==== recent research ====
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 Could a common virus trigger coeliac disease in some children?  //Tye-Din JA et al//, Norway February 2019 Could a common virus trigger coeliac disease in some children?  //Tye-Din JA et al//, Norway February 2019
  
-[[http://science.sciencemag.org/content/356/6333/44| study in humans supports a role for infection with reovirus, a seemingly innocuous virus, in triggering the development of CeD]] +[[https://science.sciencemag.org/content/356/6333/44| study in humans supports a role for infection with reovirus, a seemingly innocuous virus, in triggering the development of CeD]] 
-(({{pubmed>long:28386004}})) (({{pubmed>long:26060107}}))+(({{pmid>long:28386004}})) (({{pmid>long:26060107}}))
  
-Findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect and milder presentations are unlikely.  (({{pubmed>long:25023670}}))+Findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect and milder presentations are unlikely.  (({{pmid>long:25023670}})) 
 + 
 +In 2015 I saw that 6 individuals in the USA were suing maker of Benicar. (//presumably for bowel immunopathology caused by cytokines//). //Somewhere else I found that 1.9 million individuals are currently taking Olmesartan Medoxomil.//  //6 in 1.9 million ? Seems pretty rare to me.// (//Editor//) 
 + 
 +Gluten in "gluten-free" manufactured foods in Australia: a cross-sectional study.  (({{pmid>long:30404591}})) PMID 30404591
  
-In 2015 I read that 6 individuals in the USA are currently suing maker of Benicar. Somewhere I saw that 1.9 million individuals are currently taking Olmesartan Medoxomil.  6 in 1.9 million ? Seems pretty rare to me. (Editor) 
  
 2018 data show that OLM is an Nrf2 activator, NFkB inhibitor and apoptosis inhibitor in an experimental model of ulcerative colitis. Overall, the study indicates that OLM shows promise as a potential therapy for the treatment of human inflammatory bowel diseases.  2018 data show that OLM is an Nrf2 activator, NFkB inhibitor and apoptosis inhibitor in an experimental model of ulcerative colitis. Overall, the study indicates that OLM shows promise as a potential therapy for the treatment of human inflammatory bowel diseases. 
-(({{pubmed>long:30594690}}))+(({{pmid>long:30594690}})) 
 + 
 +Research associated with J Tye-Din   (({{pmid>long:    20650871}})) ,  (({{pmid>long:17629515}})) ,  (({{pmid>long:888}})) ,  (({{pmid>long:    19942485}})) ,  (({{pmid>long:23981538}})) ,  (({{pmid>long:16099789}})) ,  (({{pmid>long:888}}))  
 + 
  
 {{tag>diseases }} {{tag>diseases }}
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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     Romain Bouziat1,2,*, Reinhard Hinterleitner1,2,*, Judy J. Brown3,4,*, Jennifer E. Stencel-Baerenwald3,4, Mine Ikizler4,5,      Romain Bouziat1,2,*, Reinhard Hinterleitner1,2,*, Judy J. Brown3,4,*, Jennifer E. Stencel-Baerenwald3,4, Mine Ikizler4,5, 
 as link will likely break (news media) as link will likely break (news media)
-===== References =====+===== References =====</nodisp> 
home/diseases/celiac.1563572584.txt.gz · Last modified: 07.19.2019 by sallieq
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