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home:diseases:cfs [02.28.2019] – [Data] sallieqhome:diseases:cfs [06.12.2019] – [Recent research] sallieq
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 The absence of well-defined biomarkers coupled with inability to point to a single somatic cause (e.g. an infectious process) has had a devastating effect on the way patients with CFS/ME are diagnosed, treated and regarded. Even though CFS/ME is now widely regarded as a "real" disease, the most popular explanation for this illness remains that it represents an extreme form of "medically unexplained illnesses." As such, many psychiatrists have speculated that the condition is the product of maladaptive behaviors, failure to self-regulate, or any of dozens of others profoundly psychological or behavioral causes.(({{pubmed>long:18267050}})) The absence of well-defined biomarkers coupled with inability to point to a single somatic cause (e.g. an infectious process) has had a devastating effect on the way patients with CFS/ME are diagnosed, treated and regarded. Even though CFS/ME is now widely regarded as a "real" disease, the most popular explanation for this illness remains that it represents an extreme form of "medically unexplained illnesses." As such, many psychiatrists have speculated that the condition is the product of maladaptive behaviors, failure to self-regulate, or any of dozens of others profoundly psychological or behavioral causes.(({{pubmed>long:18267050}}))
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 +Three types of overlap occur among the disease states chronic fatigue syndrome (CFS), fibromyalgia (FM), multiple chemical sensitivity (MCS) and posttraumatic stress disorder (PTSD). They share common symptoms.   (({{pubmed>long:11461161}}))  
  
 An infectious etiology of chronic fatigue syndrome has long been suspected. Today, scientific evidence provides a growing, if not conclusive, link between infectious agents and CFS. For example, a 2011 study detected hundreds of unique proteins in the cerebrospinal fluid of patients with CFS as compared to healthy controls. An infectious etiology of chronic fatigue syndrome has long been suspected. Today, scientific evidence provides a growing, if not conclusive, link between infectious agents and CFS. For example, a 2011 study detected hundreds of unique proteins in the cerebrospinal fluid of patients with CFS as compared to healthy controls.
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 Altered composition of the gut microbiome    (({{pubmed>long:27338587}}))   Altered composition of the gut microbiome    (({{pubmed>long:27338587}}))  
  
 +. A decisive infectious trigger may then lead to immunization against autoantigens involved in aerobic energy production and/or hormone receptors and ion channel proteins, producing postexertional malaise and ME/CFS, affecting both muscle and brain.(({{pubmed>long:29497420}}))
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 + NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS)(({{pubmed>long:    26000145}}))
  
 +Patients with CFS showed abnormalities in 20 metabolic pathways. (({{pubmed>long:    27573827}}))
 =====Symptoms===== =====Symptoms=====
  
home/diseases/cfs.txt · Last modified: 09.14.2022 by 127.0.0.1
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