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home:diseases:cfs [02.28.2019] – [Data] sallieq | home:diseases:cfs [06.28.2019] – [Length of the MP] sallieq | ||
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The absence of well-defined biomarkers coupled with inability to point to a single somatic cause (e.g. an infectious process) has had a devastating effect on the way patients with CFS/ME are diagnosed, treated and regarded. Even though CFS/ME is now widely regarded as a " | The absence of well-defined biomarkers coupled with inability to point to a single somatic cause (e.g. an infectious process) has had a devastating effect on the way patients with CFS/ME are diagnosed, treated and regarded. Even though CFS/ME is now widely regarded as a " | ||
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+ | Three types of overlap occur among the disease states chronic fatigue syndrome (CFS), fibromyalgia (FM), multiple chemical sensitivity (MCS) and posttraumatic stress disorder (PTSD). They share common symptoms. | ||
An infectious etiology of chronic fatigue syndrome has long been suspected. Today, scientific evidence provides a growing, if not conclusive, link between infectious agents and CFS. For example, a 2011 study detected hundreds of unique proteins in the cerebrospinal fluid of patients with CFS as compared to healthy controls. | An infectious etiology of chronic fatigue syndrome has long been suspected. Today, scientific evidence provides a growing, if not conclusive, link between infectious agents and CFS. For example, a 2011 study detected hundreds of unique proteins in the cerebrospinal fluid of patients with CFS as compared to healthy controls. | ||
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The absence of clear laboratory markers affects not only how CFS is diagnosed, but whether or not it is viewed as fundamentally psychological illness, and how it is treated. | The absence of clear laboratory markers affects not only how CFS is diagnosed, but whether or not it is viewed as fundamentally psychological illness, and how it is treated. | ||
- | ==== Recent research | + | ==== Research |
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+ | There is considerable evidence that mitochondrial dysfunction is present in some CFS patients. (({{pubmed> | ||
This work contributes key elements to the development of ME/CFS diagnostics, | This work contributes key elements to the development of ME/CFS diagnostics, | ||
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Altered composition of the gut microbiome | Altered composition of the gut microbiome | ||
+ | A decisive infectious trigger may then lead to immunization against autoantigens involved in aerobic energy production and/or hormone receptors and ion channel proteins, producing postexertional malaise and ME/CFS, affecting both muscle and brain.(({{pubmed> | ||
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+ | NK cells are a necessary component of the immunological process and aberrations in their functional processes, including equivocal levels of NK cells and cytotoxic activity pre-empts recurrent viral infections, autoimmune diseases and altered inflammatory responses. NK cells are implicated in a number of diseases including chronic fatigue syndrome (CFS)(({{pubmed> | ||
+ | Patients with CFS showed abnormalities in 20 metabolic pathways. (({{pubmed> | ||
=====Symptoms===== | =====Symptoms===== | ||
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< | < | ||
- | The length of time it takes an MP patient to return to a given level of functionality seems to vary somewhat by disease. Diseases like CFS and Lyme may take longer. This may be because patients with these diseases tend to be sicker than most. | + | The length of time it takes an MP patient to return to a given level of functionality seems to vary somewhat by disease. Diseases like CFS and Lyme are likely to take longer. This may be because patients with these diseases tend to be sicker than most. |