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home:diseases:cystic_fibrosis [02.18.2019] – [Evidence of infectious cause] sallieqhome:diseases:cystic_fibrosis [09.14.2022] (current) – external edit 127.0.0.1
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 ====== Cystic fibrosis ====== ====== Cystic fibrosis ======
  
-[[http://www.mayoclinic.org/diseases-conditions/cystic-fibrosis/home/ovc-20211890}|Mayo Clinic overview]]+[[https://www.mayoclinic.org/diseases-conditions/cystic-fibrosis/home/ovc-20211890}|Mayo Clinic overview]]
  
  
-[[http://www.nhlbi.nih.gov/health/health-topics/topics/cf|NIH]]+[[https://www.nhlbi.nih.gov/health/health-topics/topics/cf|NIH]]
  
  
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 ===== Evidence of infectious cause ===== ===== Evidence of infectious cause =====
  
-Pseudomonal infection in cystic fibrosis: the battle continues.(({{pubmed>long:15482158}}))+Pseudomonal infection in cystic fibrosis: the battle continues.(({{pmid>long:15482158}}))
 <blockquote> <blockquote>
 Pseudomonas aeruginosa lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis. Infection usually begins in childhood and is responsible for respiratory failure and death in most patients with cystic fibrosis. The organism triggers an exuberant chronic inflammatory reaction which damages the airways and leads to progressive loss of lung function.  Pseudomonas aeruginosa lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis. Infection usually begins in childhood and is responsible for respiratory failure and death in most patients with cystic fibrosis. The organism triggers an exuberant chronic inflammatory reaction which damages the airways and leads to progressive loss of lung function. 
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-Evolution of airway microbiology in the infant with cystic fibrosis: role of nonpseudomonal and pseudomonal pathogens.(({{pubmed>long:1475540}}))+Evolution of airway microbiology in the infant with cystic fibrosis: role of nonpseudomonal and pseudomonal pathogens.(({{pmid>long:1475540}}))
 <blockquote>Bacterial colonization of the airways of the infant with cystic fibrosis is usually established early in life, and, once established, is difficult to eradicate and is associated with progressive lung disease.   <blockquote>Bacterial colonization of the airways of the infant with cystic fibrosis is usually established early in life, and, once established, is difficult to eradicate and is associated with progressive lung disease.  
  
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 </blockquote>  </blockquote> 
  
-ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa  (({{pubmed>long:    26206672}}))+ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa  (({{pmid>long:    26206672}}))
 <blockquote>AlgR is a key transcriptional regulator required for the expression of multiple virulence factors, including type IV pili and alginate in Pseudomonas aeruginosa. <blockquote>AlgR is a key transcriptional regulator required for the expression of multiple virulence factors, including type IV pili and alginate in Pseudomonas aeruginosa.
  
 A ΔalgR strain produced lesser biofilm than did the wild-type strain, which is consistent with a phenotype controlled by c-di-GMP.  A ΔalgR strain produced lesser biofilm than did the wild-type strain, which is consistent with a phenotype controlled by c-di-GMP. 
 +</blockquote>
 +
 +Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients.  (({{pmid>long:    20404933}}))
 +<blockquote>The concomitant development of QS malfunction significantly correlated with the reduced production of rhamnolipids and elastase and with the occurrence of mutations in the regulatory genes lasR and rhlR.
 </blockquote> </blockquote>
  
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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-===== References =====+===== References =====</nodisp> 
home/diseases/cystic_fibrosis.txt · Last modified: 09.14.2022 by 127.0.0.1
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