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--- home:diseases:diabetes1 [02.08.2019] – [Read more] sallieq
+++ home:diseases:diabetes1 [02.08.2019] – [Autoantibodies] sallieq
@@ Line 39: / Line 39: @@
-==== Autoantibodies   ====
-<relatedsection> [[home:alternate:autoimmunity#autoantibodies_are_produced_in_response_to_microbial_dna|"Autoantibodies" are produced in response to microbial DNA]] </section>
-Autoimmune diseases such as type I diabetes are characterized largely by the presence of autoantibodies. While autoantibodies were reported over a century ago, many scientists at the time were unwilling to accept the possibility that the immune system attacks its own cells. Ehrlich argued that autoimmunity was not possible and proposed the theory of horror autotoxicus to describe the body's innate aversion to immunological self-destruction by the production of autoantibodies.
-Now that humans are understood to be the product of multiple genomes, increasing evidence supports Ehrlich's view. When an innate immune system is forced to respond to a chronic microbiota, the resulting cascade of chemokines and cytokines will also stimulate an adaptive response. Antibodies are notoriously polyspecific, and the likelihood that antibodies generated to target metagenomic fragments will also target human proteins (target “self”) is finite.
-A litany of research implies a re-evaluation of the “autoantibody.” Recently researchers have shown that certain autoantibodies are created in response to several well-studied pathogens and in a variety of states.

home/diseases/diabetes1.txt · Last modified: 09.14.2022 by 127.0.0.1