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home:diseases:diabetes2 [02.08.2019] – [Recent Research] sallieq | home:diseases:diabetes2 [02.18.2019] – [Evidence of infectious cause] sallieq | ||
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===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
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- | Diabetologia. 2011 Dec; | + | < |
+ | RESEARCH HIGHLIGHTS | ||
- | Amar J, Serino M, Lange C, Chabo C, Iacovoni J, Mondot S, Lepage P, Klopp C, Mariette J, Bouchez O, Perez L, Courtney M, Marre M, Klopp P, Lantieri O, Doré J, Charles MA, Balkau B, Burcelin R; D.E.S.I.R. Study Group. | + | The presence of bacterial components in blood predicts the onset of diabetes mellitus in a large general population recounts lead author Jacques |
- | Source: Inserm U1027, University Paul Sabatier, CHU, Hôpital Rangueil, Avenue Jean Pouhles, Toulouse, France. amar.j@chu-toulouse.fr | + | Linda Koch - comment in [[http://www.nature.com/ |
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Abstract | Abstract | ||
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CONCLUSIONS/ | CONCLUSIONS/ | ||
- | 16S rDNA was shown to be an independent marker of the risk of diabetes. These findings are evidence for the concept that tissue bacteria are involved in the onset of diabetes in humans. | + | 16S rDNA was shown to be an independent marker of the risk of diabetes. These findings are evidence for the concept that tissue bacteria are involved in the onset of diabetes in humans.(({{pubmed> |
- | Comment in Diabetes: tissue bacteria predict diabetes onset. [Nat Rev Endocrinol. 2011] | + | </ |
- | PMID: 21976140</ | ||
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- | Nature Reviews Endocrinology 8, 3 (2012); published online 8 November 2011; doi:10.1038/nrendo.2011.192 | + | To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials |
+ | However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed> | ||
- | RESEARCH HIGHLIGHTS | + | Inflammation (which is intimately associated with infection) induced by cytokines (({{pubmed> |
- | The presence | + | Abrogation |
- | DIABETES | + | Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pubmed> |
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- | Tissue bacteria predict diabetes onset Amar et al. showed 16S rDNA to be an independent marker of diabetes risk, as the burden of bacteria, mainly the gram-negative proteobacteria, | + | |
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- | Original article Amar, J. et al. Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia doi: | + | |
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- | © 2011 Macmillan Publishers Limited. All rights reserved | + | |
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- | To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below). | + | |
- | However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed> | + | |
Further, beta amyloid, which has been identified as an antimicrobial peptide, | Further, beta amyloid, which has been identified as an antimicrobial peptide, | ||
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{{tag> | {{tag> | ||
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