This shows you the differences between two versions of the page.
Both sides previous revisionPrevious revisionNext revision | Previous revisionNext revisionBoth sides next revision | ||
home:diseases:diabetes2 [02.08.2019] – [Recent Research] sallieq | home:diseases:diabetes2 [02.19.2019] – [Antimicrobial therapy in insulin resistance/type 2 diabetes] sallieq | ||
---|---|---|---|
Line 34: | Line 34: | ||
- | Diet and exercise are the traditional lifestyle interventions used to prevent and treat type 2 diabetes. Different components of the diet can affect the course of type 2 diabetes, but a low carbohydrate diet appears to be giving the most significant results. (({{pubmed> | + | Diet and exercise are the traditional lifestyle interventions used to prevent and treat type 2 diabetes. Different components of the diet can affect the course of type 2 diabetes, but a low carbohydrate diet appears to be giving the most significant results. (({{pubmed> |
+ | |||
+ | Both endurance and resistance exercise yield improvements in many aspects of the metabolic derangements in diabetes type II.(({{pubmed> | ||
Sulfonylureas, | Sulfonylureas, | ||
Line 41: | Line 43: | ||
===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
- | < | ||
- | Diabetologia. 2011 Dec; | + | < |
+ | RESEARCH HIGHLIGHTS | ||
- | Amar J, Serino M, Lange C, Chabo C, Iacovoni J, Mondot S, Lepage P, Klopp C, Mariette J, Bouchez O, Perez L, Courtney M, Marre M, Klopp P, Lantieri O, Doré J, Charles MA, Balkau B, Burcelin R; D.E.S.I.R. Study Group. | + | The presence of bacterial components in blood predicts the onset of diabetes mellitus in a large general population recounts lead author Jacques |
- | Source: Inserm U1027, University Paul Sabatier, CHU, Hôpital Rangueil, Avenue Jean Pouhles, Toulouse, France. amar.j@chu-toulouse.fr | + | Linda Koch - comment in [[http://www.nature.com/ |
+ | </ | ||
+ | < | ||
Abstract | Abstract | ||
Line 65: | Line 69: | ||
CONCLUSIONS/ | CONCLUSIONS/ | ||
- | 16S rDNA was shown to be an independent marker of the risk of diabetes. These findings are evidence for the concept that tissue bacteria are involved in the onset of diabetes in humans. | + | 16S rDNA was shown to be an independent marker of the risk of diabetes. These findings are evidence for the concept that tissue bacteria are involved in the onset of diabetes in humans.(({{pubmed> |
- | Comment in Diabetes: tissue bacteria predict diabetes onset. [Nat Rev Endocrinol. 2011] | + | </ |
- | PMID: 21976140</ | ||
- | < | ||
- | Nature Reviews Endocrinology 8, 3 (2012); published online 8 November 2011; doi:10.1038/nrendo.2011.192 | + | To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials |
+ | However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed> | ||
- | RESEARCH HIGHLIGHTS | + | Inflammation (which is intimately associated with infection) induced by cytokines (({{pubmed> |
- | The presence | + | Abrogation |
- | DIABETES | + | Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pubmed> |
- | + | ||
- | Tissue bacteria predict diabetes onset Amar et al. showed 16S rDNA to be an independent marker of diabetes risk, as the burden of bacteria, mainly the gram-negative proteobacteria, | + | |
- | + | ||
- | Original article Amar, J. et al. Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia doi: | + | |
- | + | ||
- | © 2011 Macmillan Publishers Limited. All rights reserved | + | |
- | </ | + | |
- | + | ||
- | + | ||
- | To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below). | + | |
- | However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed> | + | |
Further, beta amyloid, which has been identified as an antimicrobial peptide, | Further, beta amyloid, which has been identified as an antimicrobial peptide, | ||
Line 103: | Line 95: | ||
The use of oxytetracycline in obese mice reduced insulin resistance(({{pubmed> | The use of oxytetracycline in obese mice reduced insulin resistance(({{pubmed> | ||
- | Diabetes can cause a sugar coating that smothers body's immune defences | ||
- | http:// | + | |
+ | [[http:// | ||
The researchers looked at the similarities in chemical structure between glucose in blood and body fluids, and two other sugar called mannose and fucose. These sugars are found on the surfaces of bacteria and fungi and act as targets for receptors in our body that have evolved to detect and bind to microbial sugars to then combat the infection. | The researchers looked at the similarities in chemical structure between glucose in blood and body fluids, and two other sugar called mannose and fucose. These sugars are found on the surfaces of bacteria and fungi and act as targets for receptors in our body that have evolved to detect and bind to microbial sugars to then combat the infection. | ||
Line 184: | Line 176: | ||
{{tag> | {{tag> | ||
- | < | ||