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home:diseases:diabetes2 [02.18.2019] – [Evidence of infectious cause] sallieq | home:diseases:diabetes2 [02.18.2019] – [Evidence of infectious cause] sallieq | ||
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To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below). | To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below). | ||
- | However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed> | + | However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed> |
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+ | Inflammation (which is intimately associated with infection) induced by cytokines (({{pubmed> | ||
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+ | Abrogation of inflammation ameliorates insulin resistance. (({{pubmed> | ||
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+ | Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pubmed> | ||
Further, beta amyloid, which has been identified as an antimicrobial peptide, | Further, beta amyloid, which has been identified as an antimicrobial peptide, | ||
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