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home:diseases:diabetes2 [02.18.2019] – [Evidence of infectious cause] sallieqhome:diseases:diabetes2 [02.19.2019] – [Antimicrobial therapy in insulin resistance/type 2 diabetes] sallieq
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-Diet and exercise are the traditional lifestyle interventions used to prevent and treat type 2 diabetes. Different components of the diet can affect the course of type 2 diabetes, but a low carbohydrate diet appears to be giving the most significant results. (({{pubmed>long:19099589}})) (({{pubmed>long:19419563}})) (({{pubmed>long:18397522}})) Both endurance and resistance exercise yield improvements in many aspects of the metabolic derangements in diabetes type II.(({{pubmed>long:17656625}})) +Diet and exercise are the traditional lifestyle interventions used to prevent and treat type 2 diabetes. Different components of the diet can affect the course of type 2 diabetes, but a low carbohydrate diet appears to be giving the most significant results. (({{pubmed>long:19099589}})) (({{pubmed>long:19419563}})) (({{pubmed>long:18397522}}))  
 + 
 +Both endurance and resistance exercise yield improvements in many aspects of the metabolic derangements in diabetes type II.(({{pubmed>long:17656625}})) 
  
 Sulfonylureas, biguanids, glitazones, GLP-1 analogs, DPP-4 inhibitors and insulin are the main medication groups used to treat type 2 diabetes. These medications have modulation of insulin funcion, increments in insulin sensitivity and increments in insulin production as their main mechanisms of action.  Sulfonylureas, biguanids, glitazones, GLP-1 analogs, DPP-4 inhibitors and insulin are the main medication groups used to treat type 2 diabetes. These medications have modulation of insulin funcion, increments in insulin sensitivity and increments in insulin production as their main mechanisms of action. 
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 To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below). To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below).
-However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed>long:17090751}})) Inflammation (which is intimately associated with infection) induced by cytokines (({{pubmed>long:20056828}})) (({{pubmed>long:12453891}})) (({{pubmed>long:16427608}})) leads to insulin resistance. Abrogation of inflammation ameliorates insulin resistance. (({{pubmed>long:20445103}})) (({{pubmed>long:2038201}})) (({{pubmed>long:20159859}})) (({{pubmed>long:19515743}})) Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pubmed>long:20463885}}))+However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed>long:17090751}}))  
 + 
 +Inflammation (which is intimately associated with infection) induced by cytokines (({{pubmed>long:20056828}})) (({{pubmed>long:12453891}})) (({{pubmed>long:16427608}})) leads to insulin resistance.  
 + 
 +Abrogation of inflammation ameliorates insulin resistance. (({{pubmed>long:20445103}})) (({{pubmed>long:2038201}})) (({{pubmed>long:20159859}})) (({{pubmed>long:19515743}}))  
 + 
 +Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pubmed>long:20463885}}))
  
 Further, beta amyloid, which has been identified as an antimicrobial peptide,(({{pubmed>long:20209079}})) is found in increased amounts in pancreatic beta cells of type 2 diabetics,(({{pubmed>long:18950899}})) hinting at the presence of microorganisms as a cause of the malfunction and destruction of the beta cells. Further, beta amyloid, which has been identified as an antimicrobial peptide,(({{pubmed>long:20209079}})) is found in increased amounts in pancreatic beta cells of type 2 diabetics,(({{pubmed>long:18950899}})) hinting at the presence of microorganisms as a cause of the malfunction and destruction of the beta cells.
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 The use of oxytetracycline in obese mice reduced insulin resistance(({{pubmed>long:4464837}})) The use of oxytetracycline in obese mice reduced insulin resistance(({{pubmed>long:4464837}}))
  
-Diabetes can cause a sugar coating that smothers body's immune defences 
  
-http://www.eurekalert.org/pub_releases/2010-08/uow-dcc082210.php+ 
 +[[http://www.eurekalert.org/pub_releases/2010-08/uow-dcc082210.php|Diabetes can cause a sugar coating that smothers body's immune defences]]
  
 The researchers looked at the similarities in chemical structure between glucose in blood and body fluids, and two other sugar called mannose and fucose. These sugars are found on the surfaces of bacteria and fungi and act as targets for receptors in our body that have evolved to detect and bind to microbial sugars to then combat the infection.  The researchers looked at the similarities in chemical structure between glucose in blood and body fluids, and two other sugar called mannose and fucose. These sugars are found on the surfaces of bacteria and fungi and act as targets for receptors in our body that have evolved to detect and bind to microbial sugars to then combat the infection. 
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 {{tag>diseases arrange}} {{tag>diseases arrange}}
  
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home/diseases/diabetes2.txt · Last modified: 09.14.2022 by 127.0.0.1
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