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home:diseases:diabetes2 [02.18.2019] – [Patients experiences] sallieqhome:diseases:diabetes2 [02.18.2019] – [Evidence of infectious cause] sallieq
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 To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below). To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below).
-However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed>long:17090751}})) Inflammation (which is intimately associated with infection) induced by cytokines (({{pubmed>long:20056828}})) (({{pubmed>long:12453891}})) (({{pubmed>long:16427608}})) leads to insulin resistance. Abrogation of inflammation ameliorates insulin resistance. (({{pubmed>long:20445103}})) (({{pubmed>long:2038201}})) (({{pubmed>long:20159859}})) (({{pubmed>long:19515743}})) Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pubmed>long:20463885}}))+However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed>long:17090751}}))  
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 +Inflammation (which is intimately associated with infection) induced by cytokines (({{pubmed>long:20056828}})) (({{pubmed>long:12453891}})) (({{pubmed>long:16427608}})) leads to insulin resistance.  
 + 
 +Abrogation of inflammation ameliorates insulin resistance. (({{pubmed>long:20445103}})) (({{pubmed>long:2038201}})) (({{pubmed>long:20159859}})) (({{pubmed>long:19515743}}))  
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 +Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pubmed>long:20463885}}))
  
 Further, beta amyloid, which has been identified as an antimicrobial peptide,(({{pubmed>long:20209079}})) is found in increased amounts in pancreatic beta cells of type 2 diabetics,(({{pubmed>long:18950899}})) hinting at the presence of microorganisms as a cause of the malfunction and destruction of the beta cells. Further, beta amyloid, which has been identified as an antimicrobial peptide,(({{pubmed>long:20209079}})) is found in increased amounts in pancreatic beta cells of type 2 diabetics,(({{pubmed>long:18950899}})) hinting at the presence of microorganisms as a cause of the malfunction and destruction of the beta cells.
home/diseases/diabetes2.txt · Last modified: 09.14.2022 by 127.0.0.1
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